Scientists analyzed the effect of pharmacological inhibition of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome using dapansutrile (OLT1177), an oral NLRP3-specific inhibitor that is safe in humans.
[Proceedings of the National Academy of Sciences of the United States of America]
6807162 XJ9FMMHI items 1 apa default asc 1
Lonnemann, N., Hosseini, S., Marchetti, C., Skouras, D. B., Stefanoni, D., D’Alessandro, A., Dinarello, C. A., & Korte, M. (2020). The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2009680117 Cite
In in vitro assays, NCTC1469 cells subjected to hypoxia/reoxygenation were transduced with siRNA/activator of SIRT1 or miR-182 agomir to confirm the effect of SIRT1 on NCTC1469 cell behaviors as well as the regulation of miR-182 and XBP1/NLRP3 signaling pathway.
[Molecular Therapy-Nucleic Acids]
6445212 RAHYGWYD items 1 apa default asc 1
SIRT1 Alleviates Hepatic Ischemia-Reperfusion Injury Via the miR-182-Mediated XBP1/NLRP3 Pathway: Molecular Therapy - Nucleic Acids. (n.d.). Retrieved November 26, 2020, from https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30371-1 Cite
Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.
6807162 KW32PGC2 items 1 apa default asc 1
Deng, R., Zhang, H.-L., Huang, J.-H., Cai, R.-Z., Wang, Y., Chen, Y.-H., Hu, B.-X., Ye, Z.-P., Li, Z.-L., Mai, J., Huang, Y., Li, X., Peng, X.-D., Feng, G.-K., Li, J.-D., Tang, J., & Zhu, X.-F. (2020). MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1850609 Cite
Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
6606345 S6SSNFRN items 1 apa default asc 1
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation | Cell Death & Disease. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41419-020-03178-2 Cite
This study was designed to test the hypothesis that proprotein convertase subtilisin/Kexin type 9 (PCSK9) regulates pyroptosis in cardiomyocytes during chronic myocardial ischemia. Primary cardiomyocytes were isolated from WT and PCSK9−/− mice.
[Basic Research in Cardiology]
6630899 RZYMXC8X items 1 apa default asc 1
Researchers demonstrated here that a small accessory protein of contemporary H5N1 and H3N2 influenza A viruses curtails fulminant cell death of infected human macrophages.
6445218 NHJU57HT items 1 apa default asc 1
Boal-Carvalho, I., Mazel-Sanchez, B., Silva, F., Garnier, L., Yildiz, S., Bonifacio, J. P., Niu, C., Williams, N., Francois, P., Schwerk, N., Schöning, J., Carlens, J., Viemann, D., Hugues, S., & Schmolke, M. (2020). Influenza A viruses limit NLRP3-NEK7-complex formation and pyroptosis in human macrophages. EMBO Reports, n/a(n/a), e50421. https://doi.org/10.15252/embr.202050421 Cite
An injectable hydrogel composed of sodium alginate and collagen type I was synthesized as a tissue scaffold to improve the efficacy of stem cells in a full-thickness excision wound model.
[Cell and Tissue Research]
6606345 TKITPB4R items 1 apa default asc 1
Zhang, Z., Li, Z., Li, Y., Wang, Y., Yao, M., Zhang, K., Chen, Z., Yue, H., Shi, J., Guan, F., & Ma, S. (2020). Sodium alginate/collagen hydrogel loaded with human umbilical cord mesenchymal stem cells promotes wound healing and skin remodeling. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03321-7 Cite
β-adrenergic receptor (β-AR) overactivation induced inflammasome activation in both the cardiomyocytes and cardiac fibroblasts of mice hearts following a subcutaneous injection of isoproterenol, a selective agonist of β-AR.
[Cell Death & Disease]
1254621 6BXHBINV items 1 apa default asc 1
Transcriptomic profiles of peripheral blood mononuclear cells were analyzed in heart failure patients harboring DNA methyltransferase 3a (DNMT3A) clonal hematopoiesis-driver mutations and patients with HF and no DNMT3A mutations by single-cell RNA-sequencing.
1254621 AEPVCYFZ items 1 apa default asc 1
Scientists showed that inactivating mutations in the epigenetic regulator TET2, which led to clonal hematopoiesis, aggravate age- and obesity-related insulin resistance in mice.
1254621 RNRGYHCP items 1 apa default asc 1
Investigators showed that the cytosolic pattern recognition receptor Nod-like Receptor CARD 4 suppressed, rather than facilitated, effector and memory CD4+ T-cell responses against Salmonella in mice.
6445218 JP3G8CN7 items 1 apa default asc 1
Tourlomousis, P., Wright, J. A., Bittante, A. S., Hopkins, L. J., Webster, S. J., Bryant, O. J., Mastroeni, P., Maskell, D. J., & Bryant, C. E. (2020). Modifying bacterial flagellin to evade Nod-like Receptor CARD 4 recognition enhances protective immunity against Salmonella. Nature Microbiology, 1–10. https://doi.org/10.1038/s41564-020-00801-y Cite