PI3K

[Translational Oncology] Three patient-derived cancer cells (PDCs) were established from NRAS Q61-positive metastatic melanoma patients. The response of PDCs and five established melanoma cell lines was evaluated toward a panel of 527 oncology drugs using high-throughput drug sensitivity and resistance testing.

[Genes & Development] Using melanoma as a model, the authors showed that TBX2 lied downstream from PI3K signaling and that TBX2 binds and was required for expression of E2F1, a key antisenescence cell cycle regulator.

[Cell Death & Disease] Researchers reported that nerve growth factor (NGF) facilitated lysyl oxidase-dependent cellular migration and invasion in human chondrosarcoma cells, and that NGF overexpression enhanced lung metastasis in a mouse model of chondrosarcoma.

[Journal of Biological Chemistry] Scientists examined for the first time the effect of N-myc-downregulated gene 1 (NDRG1) on androgen receptor expression, activation, and downstream signaling in LNCaP, 22Rv1 and C4-2B prostate cancer cell types.

[Archives of Pharmacal Research] Scientists provided important evidence that kaempferol targeting RSKs might be a strategy to reduce the oxaliplatin-resistant colon cancer cells.

[Oncogene] The authors found that RGMA was downregulated in breast cancer (BC) tissues compared with non-tumorous breast tissues, particularly in metastatic BC samples, and that patients with low RGMA expression manifested a poorer prognosis.