PI3K

[Cell Death & Disease] To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.

[Journal of Pharmacy and Pharmacology] With the help of cell cytotoxicity, the effect of tonkinensine B on MDA-MB-231 cells was investigated. The levels of key apoptosis-associated proteins Bcl-2, Bax, caspase-9, caspase-3 and AKT in MDA-MB-231 cells were analysed to determine whether tonkinensine B caused apoptosis via the mitochondrial pathway.

[Cell Reports] Researchers identified a human glioblastoma subset characterized by ERBB3 overexpression and nuclear accumulation.

[Cancer Gene Therapy] Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.

[Science Immunology] Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.

[Journal of Materials Chemistry B] Scientists showed that the Platelet derived growth factor-BB (PDGF-BB)/sodium alginate (SA)/dextran (Dex) hydrogels could sustainably release PDGF-BB with excellent biocompatibility in vitro and in vivo.