Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2-PTEN-AKT Pathway and Placental Cell Proliferation

Scientists showed the molecular evolution of NCK-interacting kinase-related kinase, which confered its function for inhibiting placental cell proliferation.
[Molecular Biology and Evolution]
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Hydroxysafflor Yellow a Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells through the PPARγ/PTEN/Akt Signaling Pathway

Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.
[Bioengineered]
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Implications of miR-148a-3p/p35/PTEN Signaling in Tau Hyperphosphorylation and Autoregulatory Feed-Forward of Akt/CREB in Alzheimer’s Disease

RNA sequencing, qRT-PCR, and Western blot analysis were used to identify the aberrant expression and signaling of miR-148a-3p within cells, mice, and patients with Alzheimer’s disease (AD). Researchers implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation and feed-forward regulation in AD.
[Molecular Therapy-Nucleic Acids]
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Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Facilitate the Repair of Spinal Cord Injury via the miR-29b-3p/PTEN/Akt/mTOR Axis

Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.
[Cell Death Discovery]
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Brain Endothelial PTEN/AKT/NEDD4-2/MFSD2A Axis Regulates Blood-Brain Barrier Permeability

Scientists showed that cerebrovascular endothelial cell-specific deletion of Pten resulted in a dramatic increase in vesicular transcytosis by the reduction of major facilitator superfamily domain-containing 2a, leading to increased transcellular permeability of the blood-brain barrier.
[Cell Reports]
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Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
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PRDX1 Activates Autophagy via the PTEN-AKT Signaling Pathway to Protect against Cisplatin-Induced Spiral Ganglion Neuron Damage

Macroautophagy/autophagy plays a critical role in spiral ganglion neurons (SGNs) development, but the effect of autophagy on cisplatin-induced SGN injury is unclear. Scientists found that autophagic flux was activated in SGNs after cisplatin damage.
[Autophagy]
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Inhibition of miR‐188‐5p Alleviates Hepatic Fibrosis by Significantly Reducing the Activation and Proliferation of HSCs through PTEN/PI3K/AKT Pathway

Mimicking the miR‐188‐5p resulted in the up‐regulation of hepatic stellate cell (HSC) activation and proliferation by directly targeting the phosphatase and tensin homolog (PTEN). Inhibition of miR‐188‐5p reduced the activation and proliferation markers of HSCs through PTEN/AKT pathway.
[Journal of Cellular and Molecular Medicine]
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An Autoregulatory Feedback Loop of miR-21/VMP1 Is Responsible for the Abnormal Expression of miR-21 in Colorectal Cancer Cells

Scientists found that the expression of miR-21 was negatively correlated with the expression of vacuole membrane protein-1 (VMP1) in colorectal cancer. Transcription of VMP1 activated either by small activating RNA or transcriptional activator GLI3 inhibited miR-21 expression through reducing its transcripts of VMP1-miR-21 and pri-miR-21, while no significant change in miR-21 expression after exogenous overexpression VMP1 in colorectal cancer cell HCT116.
[Cell Death & Disease]
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
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LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
[Oncogene]
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