RUNX1

[Bone Marrow Transplantation] Researchers performed a retrospective, registry-based analysis to elucidate the prognostic value of runt-related transcription factor 1 (RUNX1) mutation after allogeneic stem cell transplantation for AML patients.

[Blood] A first genetic hit led to the expansion of pre-leukemic B-cell clones, which were detectable in healthy newborn cord blood. These pre-leukemic clones gave rise to clinically overt leukemia in only about 0.2% of carriers.

[Stem Cell Reports] Utilizing CRISPR-Cas9, researchers compared the in vitro phenotype of hematopoietic progenitor cells and megakaryocytes derived from induced pluripotent stem cell lines harboring mutations in either ETV6 or RUNX1.

[Nature Communications] Scientists performed multipronged genomic analyses in longitudinally collected specimens from 60 IDH1- or IDH2-mutant AML patients treated with the inhibitors.

[Cell Stem Cell] Scientists uncovered a molecular fate switch, involving miR-206 and the transcription factor Runx1, that controls fibroadipogenic progenitor differentiation to adipocytes.

[Leukemia] The authors unraveled key components of G2DHE-bound transcription factors involved in the deregulation of EVI1.