STAT3

[Cell Death & Disease] Centrosomal P4.1-associated protein (CPAP) could increase the expression of chemokine ligand 16 (CCL-16), an important chemotactic cytokine in human hepatocytes. CCL-16 expression was positively correlated with CPAP and TNF-α mRNA expression in the peritumoral part of hepatocellular carcinoma.

[Nature Communications] Researchers showed that human hepatic organoids, engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD), developed the key features of ARPKD liver pathology in only 21 days.

[Scientific Reports] Researchers demonstrated the versatile applicability of the new MMTV-Flp strain and manipulated genes in a temporally and spatially controlled manner in the normal mammary gland, in luminal-type mammary tumors that overexpressed ERBB2, and in a new KRAS-associated mammary cancer model.

[Life Sciences] Scientists reported that IFN-γ and insulin possessed pro-proliferative effects in breast cancer and non-cancer cell lines, respectively, which were dependent on increased ASCT2-mediated glutamine transport.

[Oncogene] Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.

[Translational Psychiatry] Scientists found that bilobalide inhibited Aβ-induced and STAT3-dependent expression of TNF-α, IL-1β, and IL-6 in primary astrocyte culture.