STAT3

[Phytotherapy Research] Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.

[Cancer Cell] Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.

[Journal of Nanobiotechnology] Researchers prepared shell-core structure nanoparticles which inhibited tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the sphingosine 1 phosphate receptor 1/phosphorylated signal transducer and activator of transcription 3/vascular endothelial growth factor A axis.

[Proceedings of the National Academy of Sciences of the United States of America] Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficiency led to intestinal stem cell loss and compromised intestinal barrier integrity upon dextran sodium sulfate-induced acute injury.

[International Journal of Molecular Sciences] Investigators summarize the anti-tumor effects of miR-124. They then discuss the functions of miR-124 with that of its original role in neurons.

[Signal Transduction and Targeted Therapy] The metastatic effects of exosomes derived from highly metastatic hepatocellular carcinoma cells (HMH) were evaluated both in vitro and in vivo.