Sox2

[Cancer Letters] Scientists found that progestin resistance of endometrial CSCs could be improved or reversed by using in vitro fertilization (IVF)-generated embryonic sac-derived fluid containing the embryonic microenvironment.

[Cell Biology and Toxicology] Researchers investigated its expression profile in neuroblastoma (NB), its association with NB clinical outcomes, and its influence in the regulation of cancer stem cells’ (CSCs) stemness maintenance.

[Molecular Cancer Research] Researchers identified the cell surface binding partner of Reg4 and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.

[Experimental Cell Research] Scientists investigated the expression profile and biological function of lncRNAs in urothelial cancer stem-like cells by microarray analysis.

[Nature Communications] Investigators identified E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for glioblastoma stem cells identity and maintenance.

[Nature Communications] ARID1B-BAF regulated exit from pluripotency and lineage commitment by attenuating thousands of enhancers and genes of the NANOG and SOX2 networks. In iPSCs, these enhancers were maintained active by ARID1A-containing BAF.