T cells

[Nature Reviews Cancer] Drawing insights from autoimmunity, scientists review the molecular phenotypes, architectural contexts, antigen specificities, effector mechanisms and regulatory pathways relevant to tumor-infiltrating B lymphocytes in human cancer.

[Biochemical and Biophysical Research Communications] Scientists applied single-cell RNA sequencing and single-cell sequencing assay for transposase-accessible chromatin to systematically profile umbilical cord blood nucleated cells and peripheral blood mononuclear cells to identify their composition and differentially expressed genes.

[Nature Communications] Researchers showed the citrullination of pancreatic glucokinase as a result of inflammation, triggering autoimmunity and affecting glucokinase biological functions.

[Signal Transduction and Targeted Therapy] Scientists summarize the intrinsic mechanisms of oncolytic viruses (OVs), describe the optimization strategies for using armed OVs to enhance the effects of antitumor immunity, and highlight rational combinations of OVs with other immunotherapies in recent preclinical and clinical studies.

[Signal Transduction and Targeted Therapy] The authors unveiled a novel mechanism of the endogenous cannabinoid system-mediated suppression on T cell immunity against cancer, and suggested that cannabis and cannabinoid drugs should be avoided during immunotherapy.

[PLoS Pathogens] The authors investigated the impact of monocytes, NK cells, and CD8+ T cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type or to the HTLV-1p12KO mutant.