T cells

[Science Immunology] Researchers used an orthotopic non–small cell lung cancer mouse model to study immune checkpoint blockade-refractory CD8+ T cell responses.

[Cell Death & Disease] The authors found that apoptosis-associated epitopes-specific CD8+ T cells were present in the lymphoid organs of unprimed mice, proliferated under peptide stimulation in vitro, but failed to respond to peptide immunization in vivo, suggesting a physiological control of this response.

[King's College London] Work led by Dr. John Maher at the School of Cancer & Pharmaceutical Sciences and in Leucid Bio sees the team genetically reprogram T cells to recognise and destroy cancer cells. This is done by inserting a gene that enables the T cell to make a new protein called a CAR.

[Nature Communications] Scientists showed that chemotherapy-induced anti-cancer immunity was suppressed by the tumor microenvironment through production of the cytokine IL-6.

[Nature Communications] Investigators described an additional pathway of thymic self-antigens acquisition that enabled circulating antigenic macromolecules to access both murine and human thymi.

[Gut] FVB/NJ mice were hydrodynamically injected with AKT/Ras and Sleeping Beauty transposon to induce hepatocellular carcinoma. Mini-circle and Sleeping Beauty were used to overexpress microRNA-206 in Kupffer cells of mice.