T cells

[Nature Communications] The authors showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin are the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor micro-environment.

[Nature Communications] Scientists showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin were the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor microenvironment.

[Innovent Biologics, Inc. (PR Newswire, Inc.)] Innovent Biologics, Inc. and NeoCura Bio-Medical Technology Co., Ltd. announced that they have entered into a strategic collaboration agreement to carry out a clinical study in China on the combination therapy of sintilimab from Innovent and individualized neoantigen vaccine NEO_PLIN2101 from NeoCura.

[Precigen, Inc.] Precigen, Inc. announced that the US FDA has cleared the Investigational New Drug (IND) application to initiate the Phase I/Ib clinical trial of PRGN-3007 in advanced receptor tyrosine kinase-like orphan receptor 1-positive (ROR1+) hematological and solid tumors.

[Nature Communications] The authors found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.

[Human Gene Therapy] The authors discussed the development of viral and nonviral vectors used to generate CAR-T cells, focusing on their advantages and limitations.