T cells

[BMC Cancer] The anti-cancer activities of BD0801 and its potential synergistic anti-tumor effects when combined with different immunotherapies were assessed by using in vitro assays and in vivo tumor models.

[Nature Immunology] Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.

[Nano Letters] Sequential libraries of ionizable lipid nanoparticle formulations with varied excipient compositions were screened in comparison to a standard formulation for improved mRNA delivery to T cells with low cytotoxicity, revealing B10 as the top formulation with a 3-fold increase in mRNA delivery.

[Journal of Cellular and Molecular Medicine] Investigators explored the role of glycolysis inhibition by 2-Deoxy-D-glucose on regulating immune responses of oral lichen planus-derived T cells.

[Endocrine Journal] Investigators retrospectively analyzed 26 patients with primary thyroid lymphomas and 16 patients with benign lymphoproliferative lesions.

[Brazilian Journal of Medical and Biological Research] Lower Foxp3 and higher Bcl-6, ICOS, and PD-1 mRNA expression levels were found in patients with dilated cardiomyopathy (DCM). Plasma interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-21 levels were significantly increased in DCM cases.