T cells

[Nature Medicine] Ten of 16 patients with large B cell lymphoma with progressive disease after CAR19 treatment had absent or low CD19.

[Nanomedicine-Nanotechnology Biology and Medicine] A DNA vaccine was efficiently uptaken by dendritic cells and induced effective immune response against mouse melanoma cells, leading to significant inhibition of melanoma tumor growth and reduction of lung metastasis in a mouse model.

[Advanced Healthcare Materials] A preprocessing strategy was developed to reprogram the immunosuppressive tumor microenvironment using a thermoresponsive hydrogel loaded with doxorubicin.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.

[Cancer Research] To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, the authors generated a penetrant double oncogene-driven autochthonous model of neuroblastoma.

[Journal of Experimental Medicine] The authors discovered that selective recruitment and activation of systemic CD8+ T cells into DNA mismatch repair colorectal cancers strictly depend on overexpression of CCL5 and CXCL10 due to endogenous activation of cGAS/STING and type I IFN signaling by damaged DNA.