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T cells

Single-Cell Immune Profiling Reveals Functional Diversity of T Cells in Tuberculous Pleural Effusion

[Journal of Experimental Medicine] Using single-cell transcriptomics and T cell receptor sequencing, scientists analyzed mononuclear cell populations in paired pleural fluid and peripheral blood of tuberculous pleural effusion patients.

SARS-CoV-2 Vaccination Induces Immunological T Cell Memory Able to Cross-Recognize Variants from Alpha to Omicron

[Cell] In subjects ∼6 months post-vaccination, 90% and 87% of memory T cell responses were preserved against variants on average by AIM assay, and 84% and 85% preserved against Omicron.

Effector Memory CD4+ T Cells Induce Damaging Innate Inflammation and Autoimmune Pathology by Engaging CD40 and TNFR on Myeloid Cells

[Science Immunology] Investigators identified a critical signaling node that was engaged by effector memory T cells to mobilize a broad proinflammatory program in the innate immune system.

Synthetic Multiantigen MVA Vaccine COH04S1 Protects against SARS-CoV-2 in Syrian Hamsters and Non-Human Primates

[NPJ Vaccines] The authors demonstrated that intramuscular or intranasal vaccination of Syrian hamsters with COH04S1 induced robust Th1-biased antigen-specific humoral immunity and cross-neutralizing antibodies.

Single-Cell Multi-Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

[Nature Communications] Investigators used multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab.

HCV Infection Alters Salivary Gland Histology and Saliva Composition

[Journal of Dental Research] Researchers investigated if xerostomia associated with salivary gland (SG) and hepatitis C virus (HCV) infection and characterized the structural changes in SG and saliva composition.

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