T cells

[PLoS Pathogens] Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.

[Oncoimmunology] Investigators showed that chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) was upregulated in clear cell renal cell carcinoma tissues and was strongly associated with advanced tumor grades, early metastases, and a worse prognosis.

[Journal of Cellular and Molecular Medicine] Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.

[Journal of Immunology] The authors observed significantly fewer LAG-3+ CD4 and CD8 T cells from subjects with relapsing-remitting multiple sclerosis and type 1 diabetes.

[Journal of Immunology] Using a mouse model of sepsis, scientists found that the long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) was highly expressed in mice during the late phase of sepsis.

[Molecular Biology Reports] A considerable number of studies suggest that the role of indoleamine 2,3 dioxygenase in T helper 2 cell regulation may be different from that of T helper 1 immune responses.