T cells

[Nature Communications] The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.

[Nature Communications] Investigators comprehensively analyzed peripheral blood and/or synovial fluid samples from 20 patients with immune-related adverse events, including arthritis, and unmasked a prominent Th1-CD8+ T cell axis in both blood and inflamed joints.

[Cancer Research] The authors used carbon monoxide, a short-lived gaseous molecule, to test if engaging moderate endoplasmic reticulum stress conditions could improve mitochondrial and anti-tumor functions in T cells.

[Nature Reviews Endocrinology] The authors review the current understanding of the genetics of autoimmune Addison disease and its position in the wider field of autoimmune disorders and discuss the mechanisms that could underlie the effects on the adrenal cortex.

[Science Advances] The authors engineered simple-to-implement injectable hydrogels for the controlled co-delivery of CAR-T cells and stimulatory cytokines that improve treatment of solid tumors.

[Cytotherapy] Since Natural Killer (NK)-92 cells do not spontaneously express CCR7, clinical-grade activated NK cells were transfected with a non-viral vector containing the CCR7 receptor, an anti-CD19 CAR and a high-affinity CD16 Fc receptor.