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T cells

Complement Activation Induces Excessive T Cell Cytotoxicity in Severe COVID-19

[Cell] Researchers identified highly activated, CD16+ T cells with increased cytotoxic functions in severe COVID-19.

Safety, Immunogenicity, and Protection Provided by Unadjuvanted and Adjuvanted Formulations of a Recombinant Plant-Derived Virus-Like Particle Vaccine Candidate for COVID-19 in Nonhuman Primates

[Cellular & Molecular Immunology] Investigators reported the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a virus-like particle bearing a SARS-CoV-2 spike protein vaccine candidate formulated with or without Adjuvant System 03 or cytidine-phospho-guanosine 1018.

The Effect of Age on CD4+ T Cell Recovery in HIV-Suppressed Adult Participants: A Sub-Study from AIDS Clinical Trial Group (ACTG) A5321 and the...

[Immunity & Ageing] Researchers established a semi-mechanistic population model simultaneously describing naïve and memory CD4+ T cell trajectories in 122 participants.

Towards Large-Scale Identification of HLA-Restricted T Cell Epitopes from Four Vaccine Candidate Antigens in a Malaria Endemic Community in Ghana

[Vaccine] Investigators identified immunodominant portions of four malaria vaccine candidate antigens using peripheral blood mononuclear cells from adults with life-long exposure to malaria parasites.

Adults with Plasmodium falciparum Malaria Have Higher Magnitude and Quality of Circulating T-Follicular Helper Cells Compared to Children

[Ebiomedicine] The authors undertook a comprehensive study of T-follicular helper cells, along with B cells and antibody induction in children and adults with malaria.

YAP1 Induces Marrow Derived Suppressor Cell Recruitment in Chlamydia trachomatis Infection

[Immunology Letters] Scientists explored the role of marrow derived suppressor cells in the immune escape mechanism of Chlamydia trachomatis.

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