Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
In two–five-month-old mdx mice intravenously injected with 1 × 105 Wharton’s jelly-derived mesenchymal stem cells, fibrosis intensity and accumulation of calcium/necrotic fibers were significantly decreased.
Choi, A., Park, S. E., Jeong, J. B., Choi, S., Oh, S., Ryu, G. H., Lee, J., Jeon, H. B., & Chang, J. W. (2020). Anti-Fibrotic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1. International Journal of Molecular Sciences, 21(17), 6269. https://doi.org/10.3390/ijms21176269Cite
Scientists showed that following in vitro expansion, Wharton’s jelly MSCs were more effective than other sources of MSCs. Cell to cell contact or secretion of soluble factors and exosomes were the main approaches of MSCs in applying their effects.
Taghavi-Farahabadi, M., Mahmoudi, M., Rezaei, N., & Hashemi, S. M. (2020). Wharton’s Jelly Mesenchymal Stem Cells Exosomes and Conditioned Media Increased Neutrophil Lifespan and Phagocytosis Capacity. Immunological Investigations, 0(0), 1–16. https://doi.org/10.1080/08820139.2020.1801720Cite