Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics

Researchers characterized and compared MSCs from three regions of the umbilical cord: Wharton’s Jelly, the perivascular space and the umbilical membrane.
[Stem Cell Reviews and Reports]
Semenova, E., Grudniak, M. P., Machaj, E. K., Bocian, K., Chroscinska-Krawczyk, M., Trochonowicz, M., Stepaniec, I. M., Murzyn, M., Zagorska, K. E., Boruczkowski, D., Kolanowski, T. J., Oldak, T., & Rozwadowska, N. (2021). Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10157-3 Cite
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Pre-Conditioning of Mesenchymal Stem Cells with Piper longum L. Augments Osteogenic Differentiation

Proliferation of Wharton’s jelly MSCs treated with Piper longum L. fruit extract was assessed by MTT assay and Cell Cycle Analysis. Effect of Piper longum L. preconditioning on osteogenic differentiation was performed.
[Journal of Ethnopharmacology]
Sanap, A., Joshi, K., Shah, T., Tillu, G., & Bhonde, R. (2021). Pre-conditioning of Mesenchymal Stem Cells with Piper longum L. augments osteogenic differentiation. Journal of Ethnopharmacology, 113999. https://doi.org/10.1016/j.jep.2021.113999 Cite
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Effects of the Secretome of Human Wharton’s Jelly Mesenchymal Stem Cells on the Proliferation and Apoptosis Gene Expression of the Retinal Pigmented Epithelium

Scientists evaluated the effect of the conditioned medium secreted by human Wharton’s jelly MSCs (WJMSCs-CM) on the proliferation and apoptosis gene expression of the retinal pigmented epithelium.
[Experimental Eye Research]
Sanie-Jahromi, F., Nowroozzadeh, M. H., Khodabandeh, Z., Soheili, Z.-S., Khajehahmadi, Z., Emadi, Z., & Talebnejad, M. R. (2021). Effects of the secretome of human Wharton’s jelly mesenchymal stem cells on the proliferation and apoptosis gene expression of the retinal pigmented epithelium. Experimental Eye Research, 205, 108528. https://doi.org/10.1016/j.exer.2021.108528 Cite
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H3K9ac of TGFβRI in Human Umbilical Cord: A Potential Biomarker for Evaluating Cartilage Differentiation and Susceptibility to Osteoarthritis via a Two-Step Strategy

Two kinds of Wharton’s jelly-MSCs were applied to evaluate their chondrogenic potential in vitro through inducing chondrogenic differentiation as the first step of our strategy, one from newborns with intrauterine growth retardation (IUGR) and the other from normal newborns but treated with excessive cortisol during differentiation to simulate the excessive maternal glucocorticoid in the IUGR newborns.
[Stem Cell Research & Therapy]
Qi, Y., Li, B., Wen, Y., Yang, X., Chen, B., He, Z., Zhao, Z., Magdalou, J., Wang, H., & Chen, L. (2021). H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy. Stem Cell Research & Therapy, 12(1), 163. https://doi.org/10.1186/s13287-021-02234-8 Cite
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Vitamin E Pretreated Wharton’s Jelly-Derived Mesenchymal Stem Cells Attenuate CCl4-Induced Hepatocyte Injury In Vitro and Liver Fibrosis In Vivo

The authors used rat liver-derived hepatocytes injured by CCl4 treatment in co-culture system with Vitamin E pretreated-Wharton’s jelly-derived MSCs (WJMSCs) to evaluate the hepatoprotective effect of vitamin E-WJMSCs.
[Biochemical Pharmacology]
Tayyab Baig, M., Ghufran, H., Mehmood, A., Azam, M., Humayun, S., & Riazuddin, S. (2021). Vitamin E pretreated Wharton’s jelly-derived mesenchymal stem cells attenuate CCl4-induced hepatocyte injury in vitro and liver fibrosis in vivo. Biochemical Pharmacology, 114480. https://doi.org/10.1016/j.bcp.2021.114480 Cite
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Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts

The differentiation of Wharton jelly (WJ)-MSCs into Schwann cell-like cells was determined by analyzing Schwann cell-specific markers. The secretion of neurotrophic factors was assessed by the Neuro Discovery antibody array.
[Tissue Engineering and Regenerative Medicine]
Choi, S. J., Park, S. Y., Shin, Y. H., Heo, S.-H., Kim, K.-H., Lee, H. I., & Kim, J. K. (2021). Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-020-00329-6 Cite
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Circ6401, a Novel Circular RNA, Is Implicated in Repair of the Damaged Endometrium by Wharton’s Jelly-Derived Mesenchymal Stem Cells through Regulation of the miR-29b-1-5p/RAP1B Axis

Wharton’s jelly (WJ)-MSCs were cocultured with or without endometrial stromal cells (ESCs) damaged by mifepristone. TUNEL staining assays, EdU proliferation assays, flow cytometry apoptosis assays, and western blot assays were performed to observe the reparative effect of WJ-MSCs on damaged ESCs.
[Stem Cell Research & Therapy]
Shi, Q., Sun, B., Wang, D., Zhu, Y., Zhao, X., Yang, X., & Zhang, Y. (2020). Circ6401, a novel circular RNA, is implicated in repair of the damaged endometrium by Wharton’s jelly-derived mesenchymal stem cells through regulation of the miR-29b-1-5p/RAP1B axis. Stem Cell Research & Therapy, 11(1), 520. https://doi.org/10.1186/s13287-020-02027-5 Cite
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Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway

Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium response under KCl stimulation, as well as the key parameters of proliferation, glial progenitor marker expression and migration.
[Cellular and Molecular Neurobiology]
Sowmithra, S., Jain, N. K., Bhonde, R., & Datta, I. (2020). Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-020-01007-w Cite
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Therapeutic Efficacy of Umbilical Cord-Derived Stem Cells for Diabetes Mellitus: A Meta-Analysis Study

The clinical efficacy was evaluated based on glycemic control status and β cell function, as well as the daily insulin requirement in diabetic patients after receiving umbilical cord-derived stem cell-transplantation compared to baseline values.
[Stem Cell Research & Therapy]
Kassem, D. H., & Kamal, M. M. (2020). Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study. Stem Cell Research & Therapy, 11(1), 484. https://doi.org/10.1186/s13287-020-01996-x Cite
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An Injectable Hyaluronan–Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair

Scientists investigated the effectiveness of hyaluronan–methylcellulose hydrogels loaded with Wharton’s Jelly-derived mesenchymal stromal cell in vitro and in a rat coccygeal Intervertebral disc degeneration model.
[International Journal of Molecular Sciences]
Choi, U. Y., Joshi, H. P., Payne, S., Kim, K. T., Kyung, J. W., Choi, H., Cooke, M. J., Kwon, S. Y., Roh, E. J., Sohn, S., Shoichet, M. S., & Han, I. (2020). An Injectable Hyaluronan–Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair. International Journal of Molecular Sciences, 21(19), 7391. https://doi.org/10.3390/ijms21197391 Cite
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Biomimetic Microenvironmental Preconditioning Enhance Neuroprotective Properties of Human Mesenchymal Stem Cells Derived From Wharton’s Jelly (WJ-MSCs)

WJ-MSCs were encapsulated in 3D hydrogels derived from human fibrin or platelet lysate and the oxygen level was adjusted to physiological normoxia (5% O2).
[Scientific Reports]

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