Clinical Effects of Intrathecal Administration of Expanded Wharton Jelly Mesenchymal Stromal Cells in Patients with Chronic Complete Spinal Cord Injury: A Randomized Controlled Study

Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
[Cytotherapy]
Albu, S., Kumru, H., Coll, R., Vives, J., Vallés, M., Benito-Penalva, J., Rodríguez, L., Codinach, M., Hernández, J., Navarro, X., & Vidal, J. (2020). Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.08.008 Cite
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Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]
Kang, J. Y., Oh, M.-K., Joo, H., Park, H. S., Chae, D.-H., Kim, J., Lee, H.-R., Oh, I.-H., & Yu, K.-R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. Journal of Clinical Medicine, 9(9), 2913. https://doi.org/10.3390/jcm9092913 Cite
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Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton’s Jelly-Derived Mesenchymal Stem Cells

A proteomic approach was employed to identify specific proteins differentially expressed by wharton’s jelly derived-MSCs in comparison to those by neonatal foreskin and adult skin fibroblasts.
[International Journal of Molecular Sciences]
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Anti-Fibrotic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1

In two–five-month-old mdx mice intravenously injected with 1 × 105 Wharton’s jelly-derived mesenchymal stem cells, fibrosis intensity and accumulation of calcium/necrotic fibers were significantly decreased.
[International Journal of Molecular Sciences]
Choi, A., Park, S. E., Jeong, J. B., Choi, S., Oh, S., Ryu, G. H., Lee, J., Jeon, H. B., & Chang, J. W. (2020). Anti-Fibrotic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1. International Journal of Molecular Sciences, 21(17), 6269. https://doi.org/10.3390/ijms21176269 Cite
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Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium

Investigators studied the expression of stemness-related genes, epigenetic regulators, miRNAs related to stemness, exosomes, the cell-cycle regulators p21 and p53, and the senescence-associated genes.
[Cells]
Balzano, F., Garroni, G., Cruciani, S., Bellu, E., Dei Giudici, S., Oggiano, A., Capobianco, G., Dessole, S., Ventura, C., & Maioli, M. (2020). Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium. Cells, 9(8), 1890. https://doi.org/10.3390/cells9081890 Cite
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Wharton’s Jelly Mesenchymal Stem Cells Exosomes and Conditioned Media Increased Neutrophil Lifespan and Phagocytosis Capacity

Scientists showed that following in vitro expansion, Wharton’s jelly MSCs were more effective than other sources of MSCs. Cell to cell contact or secretion of soluble factors and exosomes were the main approaches of MSCs in applying their effects.
[Immunological investigations]
Taghavi-Farahabadi, M., Mahmoudi, M., Rezaei, N., & Hashemi, S. M. (2020). Wharton’s Jelly Mesenchymal Stem Cells Exosomes and Conditioned Media Increased Neutrophil Lifespan and Phagocytosis Capacity. Immunological Investigations, 0(0), 1–16. https://doi.org/10.1080/08820139.2020.1801720 Cite
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