WJ-MSCs

[Polymers] Different scaffold configurations were characterized in terms of morphology and a mechanical response, and their interactions with two types of stem cells and bone marrow MSCs were assessed.

[International Journal of Molecular Sciences] Preconditioning with ethionamide promoted the proliferation of Wharton’s jelly-derived MSCs by activating phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase (MEK)/extracellular signal-regulated kinase 1/2 signaling.

[Cytotherapy] Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton's jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.

[Journal of Clinical Medicine] Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.

[International Journal of Molecular Sciences] A proteomic approach was employed to identify specific proteins differentially expressed by wharton's jelly derived-MSCs in comparison to those by neonatal foreskin and adult skin fibroblasts.

[International Journal of Molecular Sciences] In two–five-month-old mdx mice intravenously injected with 1 × 105 Wharton’s jelly-derived mesenchymal stem cells, fibrosis intensity and accumulation of calcium/necrotic fibers were significantly decreased.