Zika

[Cell Reports] To understand some of the pressures that influence Zika virus (ZIKV) evolution, scientists mimicked the natural transmission cycle by repeating serial passaging of ZIKV through cultured mosquito cells and either dengue virus (DENV)-naive or DENV-immune mice.

[Cell Reports] To understand some of the pressures that influence Zika virus (ZIKV) evolution, scientists mimicked the natural transmission cycle by repeating serial passaging of ZIKV through cultured mosquito cells and either dengue virus (DENV)-naive or DENV-immune mice.

[Cell Death Discovery] Viral infection is one of the risk factors for Alzheimer's disease (AD), and scientists demonstrated that Zika virus nfection in brain organoids could trigger AD pathological features, including β-amyloid and phosphorylated-Tau expression.

[Communications Biology] To distinguish responses related to viral infection vs. recognition, the authors evaluated cotyledons perfused with either active or inactivated Zika virus (ZIKV).

[Proceedings of the National Academy of Sciences of the United States of America] Using the pseudoinfectious reporter virus particle and reverse genetics systems, researchers found dual-host affiliated insect-specific flaviviruses entered vertebrate cells as efficiently as the mosquito-borne flaviviruses but failed to initiate replication.

[Cell Reports] Scientists identified the RNA helicase DHX16 as a potential pattern recognition receptor. Silencing of DHX16 in cells and in vivo diminished IFN-I responses against influenza virus.