adipocytes

[Journal of Cell Science] Treatment of endothelial cells with insulin did not affect endothelial fatty acid uptake, but endothelial cells took up more fatty acids when exposed to media conditioned by adipocytes treated with insulin.

[Scientific Reports] Investigators found that elastolysis of elastic fibers and collagen accumulation contributed to vascular stiffening and arterial hypertension. Therefore, apelin expression could be a major element to preserve vascular homeostasis.

[Scientific Reports] Scientists showed that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffered from overt obesity, glucose intolerance, and hepatic steatosis.

[Frontiers in Cell and Developmental Biology] Investigators summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and discuss the opportunities and challenges associated with multifunctional skin organoids.

[Reviews in Endocrine & Metabolic Disorders] The authors summarize some of the knowledge regarding the presence of adipose tissue in particular tissues, describing the composition of its adipogenic precursors, and the interactions responsible for the development of organ pathologies.

[Scientific Reports] Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.