Insulin-Stimulated Adipocytes Secrete Lactate to Promote Endothelial Fatty Acid Uptake and Transport

Investigators modeled the relationship of adipocytes and endothelial cells in vitro to test the role of insulin in fatty acid transport.
[Journal of Cell Science]
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Insulin-Stimulated Adipocytes Secrete Lactate to Promote Endothelial Fatty Acid Uptake and Transport

Treatment of endothelial cells with insulin did not affect endothelial fatty acid uptake, but endothelial cells took up more fatty acids when exposed to media conditioned by adipocytes treated with insulin.
[Journal of Cell Science]
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Fas Mutation Reduces Obesity by Increasing IL-4 and IL-10 Expression and Promoting White Adipose Tissue Browning

Scientists evaluated the inflammatory cell population in the adipose tissue of MRL/lpr mice, which could potentially influence their lean phenotype. They compared beige fat activity between the MRL/MpJ and MRL/lpr mice.
[Scientific Reports]
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Eosinophil Function in Adipose Tissue Is Regulated by Krüppel-Like Factor 3 (KLF3)

Investigators examined the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging.
[Nature Communications]
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