alveolar epithelial cells

[Journal of innate Immunity] Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.

[Nature Communications] The authors reported that vaccinia C7 was a crucial virulence factor that blocked activation of the transcription factor IRF3.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Kinase inhibitor of IRE1α treatment increased the differentiation of Krt19CreERT2-lineage-traced damage-associated transient progenitors (DATPs) into type 1 alveolar epithelial cells after bleomycin injury, indicating that relief from IRE1α signaling enabled DATPs to exit the transitional state.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors demonstrated that antibody-induced leukemia inhibitory factor (LIF) blockade remodeled the lung epithelial transcriptome in association with increased apoptosis.

[Cell Death Discovery] Researchers used a library containing approved drugs to screen for drugs that preferentially reduce cell viability in lung fibroblasts from an IPF patient compared with a human alveolar epithelial cell line.

[Nature Communications] The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.