alveolar epithelial cells

[Thorax] In vitro organoids generated from epithelial cells of mouse or patient with idiopathic pulmonary fibrosis co-cultured with young, aged or retinoic acid-pretreated murine fibroblasts were used to test potential targets.

[FEBS Journal] Scientists investigated the interaction between macrophages and fibrosis‐associated alveolar epithelial cells using a bleomycin‐induced mouse pulmonary fibrosis model and a co‐culture system.

[Scientific Reports] Investigators treated hyperoxia-exposed mice and primary alveolar epithelial cells with the novel TREK-1 activators ML335 and BL1249, and quantified physiological, histological, and biochemical lung injury markers.

[Cell Death & Disease] Investigators characterized the responses of alveolar epithelium and its adjacent microvascular endothelium to viral infection under a co-culture system. SARS-CoV-2 infection caused massive virus replication and dramatic organelles remodeling in alveolar epithelial cells, alone.

[Heliyon] Researchers report that high mobility group box 1, a prototypical damage-associated molecular pattern and a central mediator of lethal inflammation, could be a potential target for innovative therapeutic strategies for COVID-19.

[Molecular Biology Reports] Critical signaling pathways related to pulmonary fibrosis (PF) were reviewed to present updates on the molecular mechanisms of PF.