Pfizer’s Abrocitinib Receives Positive CHMP Opinion for the Treatment of Adults with Moderate to Severe Atopic Dermatitis

Pfizer, Inc. announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has adopted a positive opinion recommending the 100 mg and 200 mg doses of abrocitinib, an oral, once-daily, Janus kinase 1 inhibitor, for marketing authorization to treat moderate to severe atopic dermatitis in adults who are candidates for systemic therapy.
[Pfizer, Inc.]
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Lycopus lucidus Turcz Ameliorates DNCB-Induced Atopic Dermatitis in BALB/C Mice

The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.
[Molecular Medicine Reports]
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Interleukins 4 and 13 Drive Lipid Abnormalities in Skin Cells through Regulation of Sex Steroid Hormone Synthesis

Scientists showed that in atopic dermatitis, IL-4 and IL-13 stimulated the expression of 3β-hydroxysteroid dehydrogenase 1, a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin.
[Proceedings of the National Academy of Sciences of the United States of America]
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Pimecrolimus Interferes the Therapeutic Efficacy of Human Mesenchymal Stem Cells in Atopic Dermatitis by Regulating NFAT-COX2 Signaling

Researchers investigated whether coadministration with pimecrolimus, one of the topical calcineurin inhibitors, could influence the therapeutic potential of human umbilical cord blood MSCs in atopic dermatitis.
[Stem Cell Research & Therapy]
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Lilly and Incyte Provide Update on Supplemental New Drug Application for Baricitinib for the Treatment of Moderate to Severe Atopic Dermatitis

Eli Lilly and Company and Incyte announced that the US FDA will not meet the Prescription Drug User Fee Act action date for the supplemental new drug application for baricitinib for the treatment of adults with moderate to severe atopic dermatitis (AD).
[Eli Lilly and Company, Inc.]
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The Extracellular Matrix in Skin Inflammation and Infection

Researchers review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.
[Frontiers in Cell and Developmental Biology]
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pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis

Researchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported.
[Journal of Immunology]
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Mechanisms of Microbe-Immune System Dialogue within the Skin

The authors summarize the ongoing clinical studies that are targeting the microbiome in patients with skin disorders.
[Genes & Immunity]
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Current Views on Neuropeptides in Atopic Dermatitis

The authors summarized the mechanisms of several common neuropeptides in atopic dermatitis (AD) and hypothesized that neuropeptides may be the novel potential targets in AD treatment.
[Experimental Dermatology]
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Staphylococcus cohnii Is a Potentially Biotherapeutic Skin Commensal Alleviating Skin Inflammation

Scientists found that Tmem79−/− mice spontaneously develop interleukin-17-producing T-cell-driven skin inflammation. Comparative skin microbiome analysis revealed that the disease activity index is negatively associated with S. cohnii.
[Cell Reports]
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Autoreactive T Cells and Their Role in Atopic Dermatitis

The authors evaluate the development of (autoreactive) T cells and their response to (auto)antigens, as well as the role of the peripheral tolerance in autoimmunity in the pathophysiology of atopic dermatitis (AD), including the unmet needs and gaps.
[Journal of Autoimmunity]
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