NF-κB Perturbation Reveals Unique Immunomodulatory Functions in Prx1⁺ Fibroblasts That Promote Development of Atopic Dermatitis

Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.