The single deletion of tumor necrosis factor receptor (TNFR) 1 induced subclinical colonic epithelial dysfunction and mucosal immune abnormalities, including accumulation of neutrophils and depletion of B cells.
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Liu, C. Y., Tam, S. S., Huang, Y., Dubé, P. E., Alhosh, R., Girish, N., Punit, S., Nataneli, S., Li, F., Bender, J. M., Washington, M. K., & Polk, D. B. (2020). TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108275 Cite
The authors identified distinct cues in the tissue microenvironment that differentially drive neutrophil and macrophage responses to sterile injury. Using live imaging, they found a motile zone for neutrophils, but not macrophages, in collagen-free regions and identified a specific role for interleukin-6 receptor signaling in neutrophil responses to thermal damage.
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Barros-Becker, F., Squirrell, J. M., Burke, R., Chini, J., Rindy, J., Karim, A., Eliceiri, K. W., Gibson, A., & Huttenlocher, A. (2020). Distinct tissue damage and microbial cues drive neutrophil and macrophage recruitment to thermal injury. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101699 Cite
Scientists determined the impact of tissue plasminogen activator (tPA) on immune cells and investigated the association between observed immune alteration with hemorrhagic transformation in ischemic stroke patients and in a rat model of embolic stroke.
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Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.
Inadequate hematopoietic stem cell infusion dose did not negatively impact autologous hematopoietic stem cell transplantation patient survival but significantly prolonged the time to hematopoietic engraftment.
[Leukemia & Lymphoma]
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Liu, W., Wu, M., Xie, Y., Zhang, C., Ping, L., Feng, F., Leng, X., Mi, L., Wang, X., Zhu, J., & Song, Y. (2020). Autologous hematopoietic stem cell transplantation with inadequate stem cell dose in patients with non-Hodgkin lymphoma. Leukemia & Lymphoma, 0(0), 1–7. https://doi.org/10.1080/10428194.2020.1834092 Cite
The authors investigated the pro-hematopoietic effects and underlying mechanisms of ziyuglycoside II in cyclophosphamide-induced leukopenia in mice.
[Biomedicine & Pharmacotherapy]
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Fang, H., Xie, X., Liu, P., Rao, Y., Cui, Y., Yang, S., Yu, J., Luo, Y., & Feng, Y. (2020). Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomedicine & Pharmacotherapy, 132, 110862. https://doi.org/10.1016/j.biopha.2020.110862 Cite
Researchers showed that cell-free DNA presence and clearance in plasma of healthy individuals played an indispensable role in immune system regulation.
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Scientists report a new patient with a novel frameshift mutation and compared this patient with the previously reported SMARCD2-mutant patients, aiming to provide a more comprehensive understanding of the natural course of the disease.
[Journal of Clinical Immunology]
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Yucel, E., Karakus, I. S., Krolo, A., Kiykim, A., Heredia, R. J., Tamay, Z., Cipe, F. E., Karakoc-Aydiner, E., Ozen, A., Karaman, S., Boztug, K., & Baris, S. (2020). Novel Frameshift Autosomal Recessive Loss-of-Function Mutation in SMARCD2 Encoding a Chromatin Remodeling Factor Mediates Granulopoiesis. Journal of Clinical Immunology. https://doi.org/10.1007/s10875-020-00878-4 Cite
Upregulation of IL-33 instigated type-2 inflammation in the metastatic microenvironment, and mediated recruitment of eosinophils, neutrophils and inflammatory monocytes to lung metastases.
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Shani, O., Vorobyov, T., Monteran, L., Lavie, D., Cohen, N., Raz, Y., Tsarfaty, G., Avivi, C., Barshack, I., & Erez, N. (2020). Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2116 Cite
Researchers examined the pro-angiogenic effect of N-NAM using human umbilical vein endothelial cells and the rat middle cerebral artery occlusion model of stroke.
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Kim, S.-W., Lee, H.-K., Seol, S.-I., Davaanyam, D., Lee, H., & Lee, J.-K. (2020). Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain. Scientific Reports, 10(1), 16656. https://doi.org/10.1038/s41598-020-73340-5 Cite
Scientists elucidated the function and possible role of a novel lncRNA, called lncRNA-AK149641, in the mechanism of lipopolysaccharide-induced inflammatory response in P815 mast cells.
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Zhou, Y., Gu, L., Zhang, J., Pan, J., Zhang, J., Zhao, D., & Liu, F. (2020). LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway. Scientific Reports, 10(1), 16655. https://doi.org/10.1038/s41598-020-73186-x Cite