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High miR203a-3p and miR-375 Expression in the Airways of Smokers with and without COPD

[Scientific Reports] Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition.

SNAP25 Is a Potential Prognostic Biomarker for Prostate Cancer

[Cancer Cell International] The authors indicated a relationship between synaptosome associated protein 25 (SNAP25) expression and prostate cancer, demonstrating that SNAP25 was a potential prognostic biomarker due to its vital role in immune infiltration.

Injectable Adhesive Hemostatic Gel with Tumor Acidity Neutralizer and Neutrophil Extracellular Traps Lyase for Enhancing Adoptive NK Cell Therapy Prevents Post-Resection Recurrence of Hepatocellular...

[Biomaterials] A dual pH-responsive hydrogel with tumor acidity neutralizer and neutrophil extracellular traps lyase was developed and used in combination with natural killer cell infusion for preventing post-resection hepatocellular carcinom recurrence.

Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury

[Journal of innate Immunity] Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.

mRNA-1273 and BNT162b2 COVID-19 Vaccines Elicit Antibodies with Differences in FC-Mediated Effector Functions

[Science Translational Medicine] Given our emerging appreciation for the importance of additional antibody functions beyond neutralization, we profiled the post-boost binding and functional capacity of humoral immune responses induced by the BNT162b2 and mRNA-1273 vaccines in a cohort of hospital staff.

Severe COVID-19 Is Characterized by Inflammation and Immature Myeloid Cells Early in Disease Progression

[Heliyon] Investigators identified and ranked clinical and immunological features associated with progression to severe COVID-19 in order to investigate an immunological signature of severe disease.

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