TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice

The single deletion of tumor necrosis factor receptor (TNFR) 1 induced subclinical colonic epithelial dysfunction and mucosal immune abnormalities, including accumulation of neutrophils and depletion of B cells.
[Cell Reports]
Liu, C. Y., Tam, S. S., Huang, Y., Dubé, P. E., Alhosh, R., Girish, N., Punit, S., Nataneli, S., Li, F., Bender, J. M., Washington, M. K., & Polk, D. B. (2020). TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108275 Cite
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Distinct Tissue Damage and Microbial Cues Drive Neutrophil and Macrophage Recruitment to Thermal Injury

The authors identified distinct cues in the tissue microenvironment that differentially drive neutrophil and macrophage responses to sterile injury. Using live imaging, they found a motile zone for neutrophils, but not macrophages, in collagen-free regions and identified a specific role for interleukin-6 receptor signaling in neutrophil responses to thermal damage.
[iScience]
Barros-Becker, F., Squirrell, J. M., Burke, R., Chini, J., Rindy, J., Karim, A., Eliceiri, K. W., Gibson, A., & Huttenlocher, A. (2020). Distinct tissue damage and microbial cues drive neutrophil and macrophage recruitment to thermal injury. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101699 Cite
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tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke

Scientists determined the impact of tissue plasminogen activator (tPA) on immune cells and investigated the association between observed immune alteration with hemorrhagic transformation in ischemic stroke patients and in a rat model of embolic stroke.
[Circulation Research]
Shi Kaibin, Zou Ming, Jia Dong-mei, Shi Samuel, Yang Xiaoxia, Liu Qiang, Dong Jingfei, Sheth Kevin N, Wang Xiaoying, & Shi Fu-Dong. (n.d.). tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317596 Cite
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Identification of Immune Landscape Signatures Associated with Clinical and Prognostic Features of Hepatocellular Carcinoma

Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.
[Aging]
Aging | Identification of immune landscape signatures associated with clinical and prognostic features of hepatocellular carcinoma - Full Text. (n.d.). Retrieved October 20, 2020, from https://www.aging-us.com/article/103977/text Cite
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Autologous Hematopoietic Stem Cell Transplantation with Inadequate Stem Cell Dose in Patients with Non-Hodgkin Lymphoma

Inadequate hematopoietic stem cell infusion dose did not negatively impact autologous hematopoietic stem cell transplantation patient survival but significantly prolonged the time to hematopoietic engraftment.
[Leukemia & Lymphoma]
Liu, W., Wu, M., Xie, Y., Zhang, C., Ping, L., Feng, F., Leng, X., Mi, L., Wang, X., Zhu, J., & Song, Y. (2020). Autologous hematopoietic stem cell transplantation with inadequate stem cell dose in patients with non-Hodgkin lymphoma. Leukemia & Lymphoma, 0(0), 1–7. https://doi.org/10.1080/10428194.2020.1834092 Cite
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Ziyuglycoside II Alleviates Cyclophosphamide-Induced Leukopenia in Mice via Regulation of HSPC Proliferation and Differentiation

The authors investigated the pro-hematopoietic effects and underlying mechanisms of ziyuglycoside II in cyclophosphamide-induced leukopenia in mice.
[Biomedicine & Pharmacotherapy]
Fang, H., Xie, X., Liu, P., Rao, Y., Cui, Y., Yang, S., Yu, J., Luo, Y., & Feng, Y. (2020). Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomedicine & Pharmacotherapy, 132, 110862. https://doi.org/10.1016/j.biopha.2020.110862 Cite
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Cell-Free DNA in Plasma as an Essential Immune System Regulator

Researchers showed that cell-free DNA presence and clearance in plasma of healthy individuals played an indispensable role in immune system regulation.
[Scientific Reports]
Korabecna, M., Zinkova, A., Brynychova, I., Chylikova, B., Prikryl, P., Sedova, L., Neuzil, P., & Seda, O. (2020). Cell-free DNA in plasma as an essential immune system regulator. Scientific Reports, 10(1), 17478. https://doi.org/10.1038/s41598-020-74288-2 Cite
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Novel Frameshift Autosomal Recessive Loss-of-Function Mutation in SMARCD2 Encoding a Chromatin Remodeling Factor Mediates Granulopoiesis

Scientists report a new patient with a novel frameshift mutation and compared this patient with the previously reported SMARCD2-mutant patients, aiming to provide a more comprehensive understanding of the natural course of the disease.
[Journal of Clinical Immunology]
Yucel, E., Karakus, I. S., Krolo, A., Kiykim, A., Heredia, R. J., Tamay, Z., Cipe, F. E., Karakoc-Aydiner, E., Ozen, A., Karaman, S., Boztug, K., & Baris, S. (2020). Novel Frameshift Autosomal Recessive Loss-of-Function Mutation in SMARCD2 Encoding a Chromatin Remodeling Factor Mediates Granulopoiesis. Journal of Clinical Immunology. https://doi.org/10.1007/s10875-020-00878-4 Cite
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Fibroblast-Derived IL-33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type-2 Immunity

Upregulation of IL-33 instigated type-2 inflammation in the metastatic microenvironment, and mediated recruitment of eosinophils, neutrophils and inflammatory monocytes to lung metastases.
[Cancer Research]
Shani, O., Vorobyov, T., Monteran, L., Lavie, D., Cohen, N., Raz, Y., Tsarfaty, G., Avivi, C., Barshack, I., & Erez, N. (2020). Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2116 Cite
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Ninjurin 1 Dodecamer Peptide Containing the N-Terminal Adhesion Motif (N-NAM) Exerts Proangiogenic Effects in HUVECs and in the Postischemic Brain

Researchers examined the pro-angiogenic effect of N-NAM using human umbilical vein endothelial cells and the rat middle cerebral artery occlusion model of stroke.
[Scientific Reports]
Kim, S.-W., Lee, H.-K., Seol, S.-I., Davaanyam, D., Lee, H., & Lee, J.-K. (2020). Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain. Scientific Reports, 10(1), 16656. https://doi.org/10.1038/s41598-020-73340-5 Cite
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LncRNA-AK149641 Regulates the Secretion of Tumor Necrosis Factor-α in P815 Mast Cells by Targeting the Nuclear Factor-Kappa B Signaling Pathway

Scientists elucidated the function and possible role of a novel lncRNA, called lncRNA-AK149641, in the mechanism of lipopolysaccharide-induced inflammatory response in P815 mast cells.
[Scientific Reports]
Zhou, Y., Gu, L., Zhang, J., Pan, J., Zhang, J., Zhao, D., & Liu, F. (2020). LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway. Scientific Reports, 10(1), 16655. https://doi.org/10.1038/s41598-020-73186-x Cite
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