Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.
[Circulation Research]
Burke Ryan M, Dirkx, Jr. R. A., Quijada Pearl, Lighthouse Janet K, Mohan Amy, O’Brien Meghann, Wojciechowski Wojciech, Woeller Collynn, Phipps Richard P, Alexis Jeffrey D, Ashton John, & Small Eric M. (n.d.). Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317791 Cite
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How to Turn Up the Heat on the Cold Immune Microenvironment of Metastatic Prostate Cancer

The authors discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.
[Prostate Cancer and Prostatic Diseases]
Stultz, J., & Fong, L. (2021). How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer. Prostate Cancer and Prostatic Diseases, 1–21. https://doi.org/10.1038/s41391-021-00340-5 Cite
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Human Plasmacytoid Dendritic Cells Mount a Distinct Antiviral Response to Virus-Infected Cells

Human plasmacytoid dendritic cells produced high amounts of type I interferon when incubated with live cytomegalovirus-infected fibroblasts but not with free cytomegalovirus
[Science Immunology]
Yun, T. J., Igarashi, S., Zhao, H., Perez, O. A., Pereira, M. R., Zorn, E., Shen, Y., Goodrum, F., Rahman, A., Sims, P. A., Farber, D. L., & Reizis, B. (2021). Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells. Science Immunology, 6(58). https://doi.org/10.1126/sciimmunol.abc7302 Cite
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KRAS Mutant Rectal Cancer Cells Interact with Surrounding Fibroblasts to Deplete the Extracellular Matrix

Scientists found that KRAS‐mutant tumors displayed lower expression of genes related to the tumor stroma and remodeling of the extracellular matrix.
[Molecular Oncology]
Kim, J. K., Marco, M. R., Choi, S.-H., Qu, X., Chen, C.-T., Elkabets, M., Fairchild, L., Chow, O., Barriga, F. M., Dow, L. E., O’Rourke, K., Szeglin, B., Yarilin, D., Fujisawa, S., Manova‐Todorova, K., Paty, P. B., Shia, J., Leslie, C., Smith, J. J., … Garcia‐Aguilar, J. (n.d.). KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12960 Cite
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Current Standards and Pitfalls Associated with the Transfection of Primary Fibroblast Cells

Scientists describe critical points that should be considered when selecting a method for transfecting fibroblasts.
[Biotechnology Progress]
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Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin-Gut Axis Communication

Scientists studied the role of exopolysaccharides produced by lactic acid bacteria identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells.
[Molecules]
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Transcriptome Analysis of Human Dermal Fibroblasts Following Red Light Phototherapy

Scientists report that red light may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-infrared light and undergo photophysical reactions.
[Scientific Reports]
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Endothelial Wnts Control Mammary Epithelial Patterning via Fibroblast Signaling

To enable cell-type-specific gene manipulation in vitro, scientists establish an organoid system via coculture of endothelial cells (ECs), fibroblasts, and mammary epithelial cells.
[Cell Reports]
Wang, J., Song, W., Yang, R., Li, C., Wu, T., Dong, X. B., Zhou, B., Guo, X., Chen, J., Liu, Z., Yu, Q. C., Li, W., Fu, J., & Zeng, Y. A. (2021). Endothelial Wnts control mammary epithelial patterning via fibroblast signaling. Cell Reports, 34(13). https://doi.org/10.1016/j.celrep.2021.108897 Cite
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Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Crest Cells for Corneal Endothelial Regeneration

Transplantation of the hiPSC-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
[Stem Cell Research & Therapy]
Gong, Y., Duan, H., Wang, X., Zhao, C., Li, W., Dong, C., Li, Z., & Zhou, Q. (2021). Transplantation of human induced pluripotent stem cell-derived neural crest cells for corneal endothelial regeneration. Stem Cell Research & Therapy, 12(1), 214. https://doi.org/10.1186/s13287-021-02267-z Cite
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CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis

Scientists investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis. Conditional CD148 fibroblast-specific knockout mice were generated and exposed to bleomycin, and then assessed for pulmonary fibrosis.
[American Journal of Respiratory and Critical Care Medicine]
Tsoyi, K., Liang, X., De Rossi, G., Ryter, S. W., Xiong, K., Chu, S. G., Liu, X., Ith, B., Celada, L. J., Romero, F., Robertson, M. J., Esposito, A. J., Poli, S., El-Chemaly, S., Perrella, M. A., Shi, Y., Whiteford, J., & Rosas, I. O. (2021). CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202008-3100OC Cite
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Endogenous Mitochondrial Double‐Stranded RNA is Not an Activator of the Type I Interferon Response in Human Pancreatic Beta Cells

Researchers suggested that accumulation of endogenous mtdsRNA following degradosome knockdown depended on the proliferative capacity of the cells and was not a mediator of the type I interferon response in human pancreatic beta cells.
[Autoimmunity Highlights]
Coomans de Brachène, A., Castela, A., Musuaya, A. E., Marselli, L., Marchetti, P., & Eizirik, D. L. (2021). Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells. Autoimmunity Highlights, 12(1), 6. https://doi.org/10.1186/s13317-021-00148-2 Cite
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