Tag Archives: fibroblasts

Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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Skin Protein-Derived Peptide-Conjugated Vesicular Nanocargos for Selected Skin Cell Targeting and Consequent Activation

Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.
[Journal of Materials Chemistry B]
Cho, J. H., Kang, J. Y., Kim, S., Baek, H. R., Kim, J., Jang, K.-S., & Kim, J. W. (2021). Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00935D Cite
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COL11A1 Activates Cancer-Associated Fibroblasts by Modulating TGF-β3 through the NF-κB/IGFBP2 Axis in Ovarian Cancer Cells

Collagen type XI alpha 1 (COL11A1) is overexpressed in cancer-associated fibroblasts (CAFs); therefore this study examined its role during CAF activation in epithelial ovarian cancer.
[Oncogene]
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YAP/TAZ Suppress Drug Penetration into Hepatocellular Carcinoma via Stromal Activation

Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.
[Hepatology]
Cho, K., Ro, S. W., Lee, H. W., Moon, H., Han, S., Kim, H. R., Ahn, S. H., Park, J. Y., & Kim, D. Y. (n.d.). YAP/TAZ suppress drug penetration into hepatocellular carcinoma via stromal activation. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.32000 Cite
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m6A Modification Regulates Lung Fibroblast-to-Myofibroblast Transition through Modulating KCNH6 mRNA Translation

Researchers revealed that m6A modification was up-regulated in bleomycin induced pulmonary fibrosis mice model, FMT-derived myofibroblasts and idiopathic pulmonary fibrosis patient lung samples.
[Molecular Therapy]
Zhang, J., Huang, P., Wang, D., Yang, W., Lu, J., Zhu, Y., Meng, X., Wu, X., Lin, Q., Lv, H., Xie, H., & Wang, R. (2021). m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.06.008 Cite
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Signaling Pathways in Cancer-Associated Fibroblasts and Targeted Therapy for Cancer

Scientists summarize the enormous amounts of findings on the signals mediating crosstalk of cancer-associated fibroblasts with cancer cells and its related targets or trials.
[Signal Transduction and Targeted Therapy]
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Impairment of a Distinct Cancer-Associated Fibroblast Population Limits Tumor Growth and Metastasis

The authors showed that genetic deletion of the Endo180 (MRC2) receptor, predominantly expressed by a population of matrix-remodeling cancer-associated fibroblasts, profoundly limited tumor growth and metastasis; effects that could be recapitulated in 3D co-culture assays.
[Nature Communications]
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AP-1 Is a Temporally Regulated Dual Gatekeeper of Reprogramming to Pluripotency

Scientists examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion with murine ESCs. Efficient reprogramming of human fibroblasts to iPSCs was achieved by transduction with vectors expressing SOX2, KLF4, and inducible dnAP-1, demonstrating that dnAP-1 can substitute for exogenous human OCT4.
[Proceedings of the National Academy of Sciences of the United States of America]
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An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells

Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.
[Stem Cell Reviews and Reports]
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αSMA+ Fibroblasts Suppress Lgr5+ Cancer Stem Cells and Restrain Colorectal Cancer Progression

Scientists demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exert tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.
[Oncogene]
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Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ-on-a-Chip Vasculature

3D vascularized pancreatic adenocarcinoma tissue was microengineered in a tri-culture system composed of patient-derived pancreatic organoids, human fibroblasts, and endothelial cells on a perfusable platform, situated in a 96-well plate.
[Advanced Functional Materials]
Nakagami, H., Hayashi, H., Shimamura, M., Rakugi, H., & Morishita, R. (2021). Therapeutic vaccine for chronic diseases after the COVID-19 Era. Hypertension Research, 1–7. https://doi.org/10.1038/s41440-021-00677-3 Cite
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