Tag Archives: fibroblasts

Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling

In rat and mouse models of ischemic heart failure, investigators showed that miR-30d gain of function improves cardiac function, decreases myocardial fibrosis, and attenuates cardiomyocyte apoptosis.
[Circulation Research]
Li Jin, Salvador Ane M, Li Guoping, Valkov Nedyalka, Ziegler Olivia, Yeri Ashish Suresh, Xiao Chun Yang, Meechoovet Bessie, Alsop Eric, Rodosthenous Rodosthenis S, Kundu Piyusha, Huan TianXiao, Levy Daniel, Tigges John C, Pico Alexander R, Ghiran Ionita, Silverman Michael G, Meng Xiangmin, Kitchen Robert, … Das Saumya. (n.d.). Mir-30d Regulates Cardiac Remodeling by Intracellular And Paracrine Signaling. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317244 Cite
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Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

To what extent stromal cells in the tumor microenvironment are transformed by colorectal cancer (CRC) cells is unexplored.To dissect alterations in these non-malignant cells, researchers performed single-cell multiomics sequencing of 21 patients with microsatellite-stable colorectal cancers and 6 cancer-free, elderly individuals.
[Cancer Cell]
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer: Cancer Cell. (n.d.). Retrieved October 23, 2020, from https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30489-X?rss=yes&utm_source=dlvr.it&utm_medium=twitter Cite
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Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

To what extent stromal cells in the tumor microenvironment (TME) are transformed by colorectal cancer (CRC) cells is unexplored. Researchers performed single-cell multiomics sequencing of 21 patients with microsatellite-stable CRCs and six cancer-free, elderly individuals.
[Cancer Cell]
Zhou, Y., Bian, S., Zhou, X., Cui, Y., Wang, W., Wen, L., Guo, L., Fu, W., & Tang, F. (2020). Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.09.015 Cite
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IL-8/CXCR2 Mediates Tropism of Human Bone Marrow-Derived Mesenchymal Stem Cells toward CD133+/CD44+ Colon Cancer Stem Cells

Low concentration of IL‐8 peptide inhibitors (100 ng/ml) and CXC receptor 2 (CXCR2) inhibitors had little effect on the migration of bone marrow‐derived MSCs, but could effectively weaken colon cancer stem cell stemness (CSCs) and promoted dormant CSCs in the coculture system to re‐enter into the cell cycle.
[Journal of Cellular Physiology]
Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
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Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons

Scientists showed that three transcription factors, Ascl1, Brn3b, and Isl1, efficiently converted fibroblasts into RGC-like neurons (iRGCs). The competence of cells to enter iRGC reprogramming route was determined by the cell-cycle status at a very early stage of the process.
[Stem Cell Reports]
Wang, J., He, Q., Zhang, K., Sun, H., Zhang, G., Liang, H., Guo, J., Hao, L., Ke, J., & Chen, S. (2020). Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.09.008 Cite
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IL-8/CXCR2 Mediates Tropism of Human Bone Marrow-Derived Mesenchymal Stem Cells toward CD133+/CD44+ Colon Cancer Stem Cells

Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133−/CD44−, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]
Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
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Exosome-Mediated Metabolic Reprogramming: The Emerging Role in Tumor Microenvironment Remodeling and Its Influence on Cancer Progression

The authors present the role of exosomes in the tumor microenvironment and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.
[Signal Transduction and Targeted Therapy]
Yang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020). Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00359-5 Cite
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Dermal Fibroblasts Have Different Extracellular Matrix Profiles Induced by TGF-β, PDGF and IL-6 in a Model for Skin Fibrosis

Researchers investigated the expression of extracellular matrix by dermal fibroblast mimicking fibrotic skin diseases as systemic sclerosis using clinically validated biomarkers.
[Scientific Reports]
Juhl, P., Bondesen, S., Hawkins, C. L., Karsdal, M. A., Bay-Jensen, A.-C., Davies, M. J., & Siebuhr, A. S. (2020). Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis. Scientific Reports, 10(1), 17300. https://doi.org/10.1038/s41598-020-74179-6 Cite
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JMJD3 Acts in Tandem with KLF4 to Facilitate Reprogramming to Pluripotency

On one side, JMJD3 induced the pro-senescence factor Ink4a and degraded the pluripotency regulator PHF20 in a reprogramming factor-independent manner. On the other side, JMJD3 was specifically recruited by KLF4 to reduce H3K27me3 at both enhancers and promoters of epithelial and pluripotency genes.
[Nature Communications]
Huang, Y., Zhang, H., Wang, L., Tang, C., Qin, X., Wu, X., Pan, M., Tang, Y., Yang, Z., Babarinde, I. A., Lin, R., Ji, G., Lai, Y., Xu, X., Su, J., Wen, X., Satoh, T., Ahmed, T., Malik, V., … Qin, B. (2020). JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications, 11(1), 5061. https://doi.org/10.1038/s41467-020-18900-z Cite
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Probing Single-Cell Metabolism Reveals Prognostic Value of Highly Metabolically Active Circulating Stromal Cells in Prostate Cancer

Single-cell mRNA-sequencing analysis of the highly metabolically (hm) active cells from metastatic prostate cancer patients revealed that approximately 10% were canonical EpCAM+ hm-circulating stromal cells (CStCs), 3% were EpCAM− hm-CTCs with up-regulation of prostate-related genes, and 87% were hm-CStCs with profiles characteristic for cancer-associated fibroblasts, mesenchymal stem cells, and endothelial cells.
[Science Advances]
Rivello, F., Matuła, K., Piruska, A., Smits, M., Mehra, N., & Huck, W. T. S. (2020). Probing single-cell metabolism reveals prognostic value of highly metabolically active circulating stromal cells in prostate cancer. Science Advances, 6(40), eaaz3849. https://doi.org/10.1126/sciadv.aaz3849 Cite
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Therapeutic Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders

The authors give a brief description of MSCs, their sources and markers, and the different attempts that have been made towards achieving the goal of differentiating MSCs into neurons.
[Journal of Molecular Neuroscience]
Choudhary, P., Gupta, A., & Singh, S. (2020). Therapeutic Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders. Journal of Molecular Neuroscience. https://doi.org/10.1007/s12031-020-01714-5 Cite
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