Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

With the clinical trials and extensive basic research studying the biology of iPSCs, a promising future for human cell-based therapies using iPSCs seems to be increasingly clear and close.
[International Journal of Molecular Sciences]
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Environmentally Controlled Magnetic Nano-Tweezer for Living Cells and Extracellular Matrices

The magnetic tweezer technique can be used to analyze the mechanical properties of cells and extracellular matrices. Scientists established a magnetic tweezer capable of measuring the linear and non-linear viscoelastic behavior of a wide range of soft matter in precisely controlled environmental conditions.
[Scientific Reports]
Aermes, C., Hayn, A., Fischer, T., & Mierke, C. T. (2020). Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices. Scientific Reports, 10(1), 13453. https://doi.org/10.1038/s41598-020-70428-w Cite
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The Role of the Oncostatin M/Osm Receptor β Axis in Activating Dermal Microvascular Endothelial Cells in Systemic Sclerosis

Cell culture experiments were performed in human dermal microvascular endothelial cells and included mRNA and protein analysis, and cell migration and proliferation assays. Ex vivo skin organoid culture was used to evaluate the effect of OSM on perivascular fibrosis.
[Arthritis Research & Therapy]
Marden, G., Wan, Q., Wilks, J., Nevin, K., Feeney, M., Wisniacki, N., Trojanowski, M., Bujor, A., Stawski, L., & Trojanowska, M. (2020). The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Research & Therapy, 22(1), 179. https://doi.org/10.1186/s13075-020-02266-0 Cite
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The Prostaglandin Synthases, COX-2 and L-PGDS, Mediate Prostate Hyperplasia Induced by Low-Dose Bisphenol A

In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
[Scientific Reports]
Wu, S., Huang, D., Su, X., Yan, H., Ma, A., Li, L., Wu, J., & Sun, Z. (2020). The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A. Scientific Reports, 10(1), 13108. https://doi.org/10.1038/s41598-020-69809-y Cite
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The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells

Scientists hypothesized that designed peptides with a wide spectrum of selective antimicrobial activity will also have anticancer activity, and tested this hypothesis with newly designed peptides.
[Molecules]
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Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

Researchers investigated the metabolic landscape of Danon disease by applying a multi-omics approach and combined structural and functional readouts provided by Raman and atomic force microscopy.
[Journal of Clinical Medicine]
Del Favero, G., Bonifacio, A., Rowland, T. J., Gao, S., Song, K., Sergo, V., Adler, E. D., Mestroni, L., Sbaizero, O., & Taylor, M. R. G. (2020). Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes. Journal of Clinical Medicine, 9(8), 2457. https://doi.org/10.3390/jcm9082457 Cite
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Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, Including Muscular Dystrophies

iPSC cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy. The reprogramming of cells, such as fibroblasts, to an ESC-like state is done by the ectopic expression of transcription factors responsible for generating embryonic stem cell properties.
[International Journal of Molecular Sciences]
Gois Beghini, D., Iwao Horita, S., Cascabulho, C. M., Anastácio Alves, L., & Henriques-Pons, A. (2020). Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies. International Journal of Molecular Sciences, 21(15), 5467. https://doi.org/10.3390/ijms21155467 Cite
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Continuous ES/Feeder Cell-Sorting Device Using Dielectrophoresis and Controlled Fluid Flow

To culture PSCs on feeder cell layers, the elimination of feeder cells is required for biological or gene analysis and for cell passage. Therefore, a simple and cost-effective cell sorting technology is required. The authors focused on dielectrophoresis phenomena for cell separation because these do not require any fluorescent or magnetic dyes or antibodies.
[Micromachines]
Takahashi, Y., & Miyata, S. (2020). Continuous ES/Feeder Cell-Sorting Device Using Dielectrophoresis and Controlled Fluid Flow. Micromachines, 11(8), 734. https://doi.org/10.3390/mi11080734 Cite
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Human Pluripotent Stem Cell-Derived Cardiomyocytes as a Target Platform for Paracrine Protection by Cardiac Mesenchymal Stromal Cells

Investigators tested the impact of paracrine signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes as the target of mouse and human cardiac mesenchymal stromal cells with progenitor-like features.
[Scientific Reports]
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Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer

The authors examined the potential of natural AKR1C3 inhibitors in various prostate cancer cell lines and a three-dimensional co-culture spheroid model consisting of cancer cells and cancer-associated fibroblasts mimicking enzalutamide resistant prostate cancer.
[Cancers]
Kafka, M., Mayr, F., Temml, V., Möller, G., Adamski, J., Höfer, J., Schwaiger, S., Heidegger, I., Matuszczak, B., Schuster, D., Klocker, H., Bektic, J., Stuppner, H., & Eder, I. E. (2020). Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer. Cancers, 12(8), 2092. https://doi.org/10.3390/cancers12082092 Cite
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An Immunohistochemical Prostate Cell Identification Key Indicates that Aging Shifts Procollagen 1A1 Production from Myofibroblasts to Fibroblasts in Dogs Prone to Prostate-Related Urinary Dysfunction

Scientists characterized the regional distribution of prostatic cell types in the young intact dog to enable comparisons with human and mice and they examined how the cellular source of procollagen 1A1 changes with age in intact male dogs.
[PLoS One]
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Gold Nanoparticle Mediated Radiation Response among Key Cell Components of the Tumour Microenvironment for the Advancement of Cancer Nanotechnology

To investigate interactions in the tumor microenvironment, scientists used normal fibroblasts and cancer associated fibroblasts along with HeLa cell line to evaluate the differences in gold nanoparticles uptake and resulting radiation induced damage.
[Scientific Reports]
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