Pretreatment of Aged Mice with Retinoic Acid Supports Alveolar Regeneration via Upregulation of Reciprocal PDGFA Signaling

In vitro organoids generated from epithelial cells of mouse or patient with idiopathic pulmonary fibrosis co-cultured with young, aged or retinoic acid-pretreated murine fibroblasts were used to test potential targets.
[Thorax]
Gokey, J. J., Snowball, J., Green, J., Waltamath, M., Spinney, J. J., Black, K. E., Hariri, L. P., Xu, Y., & Perl, A. K. (2021). Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. https://doi.org/10.1136/thoraxjnl-2020-214986 Cite
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Heterogeneous Induction of an Invasive Phenotype in Prostate Cancer Cells by Coculturing with Patient-Derived Fibroblasts

The authors investigated the effects of ten different patient‐derived fibroblast lines on the 3D morphogenesis of prostate cancer cells growing on a viscous substrate in vitro.
[Journal of Cellular Biochemistry]
Ishii, K., Nakagawa, Y., Matsuda, C., Katoh, D., Ichishi, M., Shirai, T., Hirokawa, Y., Fujiwara, M., Sugimura, Y., & Watanabe, M. (n.d.). Heterogeneous induction of an invasive phenotype in prostate cancer cells by coculturing with patient-derived fibroblasts. Journal of Cellular Biochemistry, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcb.29893 Cite
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Epithelium-Derived Indian Hedgehog Restricts Stromal Expression of ErbB Family Members That Drive Colonic Tumor Cell Proliferation

Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
[Oncogene]
Westendorp, F., Karpus, O. N., Koelink, P. J., Vermeulen, J. L. M., Meisner, S., Koster, J., Büller, N. V. J. A., Wildenberg, M. E., Muncan, V., & van den Brink, G. R. (2021). Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01633-0 Cite
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Re-Expression of REG Family and DUOXs Genes in CRC Organoids by Co-Culturing With CAFs

Researchers found that the expression levels of several genes, which were highly expressed in original colorectal carcinoma tissues, were downregulated in organoids but re-expressed in organoids by co-culturing with cancer-associated fibroblasts.
[Scientific Reports]
Naruse, M., Ochiai, M., Sekine, S., Taniguchi, H., Yoshida, T., Ichikawa, H., Sakamoto, H., Kubo, T., Matsumoto, K., Ochiai, A., & Imai, T. (2021). Re-expression of REG family and DUOX s genes in CRC organoids by co-culturing with CAFs. Scientific Reports, 11(1), 2077. https://doi.org/10.1038/s41598-021-81475-2 Cite
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Thrombospondin 4/Integrin α2/HSF1 Axis Promotes Proliferation and Cancer Stem-Like Traits of Gallbladder Cancer by Enhancing Reciprocal Crosstalk between Cancer-Associated Fibroblasts and Tumor Cells

Peritumoral fibroblasts and cancer-associated fibroblasts were extracted from gallbladder cancer (GBC) tissues. Thrombospondin expression in GBC was screened by RT-qPCR.
[Journal of Experimental & Clinical Cancer Research]
Shi, Y., Sun, L., Zhang, R., Hu, Y., Wu, Y., Dong, X., Dong, D., Chen, C., Geng, Z., Li, E., & Fan, Y. (2021). Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells. Journal of Experimental & Clinical Cancer Research, 40(1), 14. https://doi.org/10.1186/s13046-020-01812-7 Cite
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Fibroblast Activation Protein Targeted Near Infrared Photoimmunotherapy (NIR PIT) Overcomes Therapeutic Resistance in Human Esophageal Cancer

Scientists evaluated whether esophageal cancer cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by cancer-associated fibroblasts.
[Scientific Reports]
Katsube, R., Noma, K., Ohara, T., Nishiwaki, N., Kobayashi, T., Komoto, S., Sato, H., Kashima, H., Kato, T., Kikuchi, S., Tazawa, H., Kagawa, S., Shirakawa, Y., Kobayashi, H., & Fujiwara, T. (2021). Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer. Scientific Reports, 11(1), 1693. https://doi.org/10.1038/s41598-021-81465-4 Cite
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6-Gingerol Protects against Cardiac Remodeling by Inhibiting the p38 Mitogen-Activated Protein Kinase Pathway

Neonatal rat cardiomyocytes and cardiac fibroblasts were used to validate the protective effects of 6-gingerol in response to phenylephrine and transforming growth factor-β challenge.
[Acta Pharmacologica Sinica]
Ma, S., Guo, Z., Liu, F., Hasan, S.-G., Yang, D., Tang, N., An, P., Wang, M., Wu, H., Yang, Z., Fan, D., & Tang, Q. (2021). 6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00587-z Cite
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Integrated, Automated Maintenance, Expansion and Differentiation of 2D and 3D Patient-Derived Cellular Models for High Throughput Drug Screening

Scientists provided automated protocols for neuronal differentiation of neural progenitor cells in 2D culture and 3D midbrain organoids for high throughput screenings.
[Scientific Reports]
Boussaad, I., Cruciani, G., Bolognin, S., Antony, P., Dording, C. M., Kwon, Y.-J., Heutink, P., Fava, E., Schwamborn, J. C., & Krüger, R. (2021). Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening. Scientific Reports, 11(1), 1439. https://doi.org/10.1038/s41598-021-81129-3 Cite
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The Ubiquitin Proteasome System and Skin Fibrosis

The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy]
Shen, W., Zhang, Z., Ma, J., Lu, D., & Lyu, L. (2021). The Ubiquitin Proteasome System and Skin Fibrosis. Molecular Diagnosis & Therapy. https://doi.org/10.1007/s40291-020-00509-z Cite
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Induced Hepatic Stellate Cell Integrin, α8β1, Enhances Cellular Contractility and TGFβ Activity in Liver Fibrosis

Integrin α‐subunits were investigated systematically for their expression over the course of hepatic stellate cells activation and their distribution on fibroblasts and other systemic primary cells.
[Journal of Pathology]
Nishimichi, N., Tsujino, K., Kanno, K., Sentani, K., Kobayashi, T., Chayama, K., Sheppard, D., & Yokosaki, Y. (n.d.). Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5618 Cite
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Dermal Fibroblasts Cultured from Donors with Type 2 Diabetes Mellitus Retain an Epigenetic Memory Associated with Poor Wound Healing Responses

Dermal fibroblasts (DF) are critical for effective wound healing, so the authors sought to establish whether there were any differences in DF cultured from Type 2 diabetes mellitus donors or those without diabetes.
[Scientific Reports]
Al-Rikabi, A. H. A., Tobin, D. J., Riches-Suman, K., & Thornton, M. J. (2021). Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports, 11(1), 1474. https://doi.org/10.1038/s41598-020-80072-z Cite
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