In vitro organoids generated from epithelial cells of mouse or patient with idiopathic pulmonary fibrosis co-cultured with young, aged or retinoic acid-pretreated murine fibroblasts were used to test potential targets.
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Gokey, J. J., Snowball, J., Green, J., Waltamath, M., Spinney, J. J., Black, K. E., Hariri, L. P., Xu, Y., & Perl, A. K. (2021). Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. https://doi.org/10.1136/thoraxjnl-2020-214986 Cite
The authors investigated the effects of ten different patient‐derived fibroblast lines on the 3D morphogenesis of prostate cancer cells growing on a viscous substrate in vitro.
[Journal of Cellular Biochemistry]
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Ishii, K., Nakagawa, Y., Matsuda, C., Katoh, D., Ichishi, M., Shirai, T., Hirokawa, Y., Fujiwara, M., Sugimura, Y., & Watanabe, M. (n.d.). Heterogeneous induction of an invasive phenotype in prostate cancer cells by coculturing with patient-derived fibroblasts. Journal of Cellular Biochemistry, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcb.29893 Cite
Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
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Westendorp, F., Karpus, O. N., Koelink, P. J., Vermeulen, J. L. M., Meisner, S., Koster, J., Büller, N. V. J. A., Wildenberg, M. E., Muncan, V., & van den Brink, G. R. (2021). Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01633-0 Cite
Researchers found that the expression levels of several genes, which were highly expressed in original colorectal carcinoma tissues, were downregulated in organoids but re-expressed in organoids by co-culturing with cancer-associated fibroblasts.
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Naruse, M., Ochiai, M., Sekine, S., Taniguchi, H., Yoshida, T., Ichikawa, H., Sakamoto, H., Kubo, T., Matsumoto, K., Ochiai, A., & Imai, T. (2021). Re-expression of REG family and DUOX s genes in CRC organoids by co-culturing with CAFs. Scientific Reports, 11(1), 2077. https://doi.org/10.1038/s41598-021-81475-2 Cite
Peritumoral fibroblasts and cancer-associated fibroblasts were extracted from gallbladder cancer (GBC) tissues. Thrombospondin expression in GBC was screened by RT-qPCR.
[Journal of Experimental & Clinical Cancer Research]
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Shi, Y., Sun, L., Zhang, R., Hu, Y., Wu, Y., Dong, X., Dong, D., Chen, C., Geng, Z., Li, E., & Fan, Y. (2021). Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells. Journal of Experimental & Clinical Cancer Research, 40(1), 14. https://doi.org/10.1186/s13046-020-01812-7 Cite
Scientists evaluated whether esophageal cancer cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by cancer-associated fibroblasts.
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Katsube, R., Noma, K., Ohara, T., Nishiwaki, N., Kobayashi, T., Komoto, S., Sato, H., Kashima, H., Kato, T., Kikuchi, S., Tazawa, H., Kagawa, S., Shirakawa, Y., Kobayashi, H., & Fujiwara, T. (2021). Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer. Scientific Reports, 11(1), 1693. https://doi.org/10.1038/s41598-021-81465-4 Cite
Neonatal rat cardiomyocytes and cardiac fibroblasts were used to validate the protective effects of 6-gingerol in response to phenylephrine and transforming growth factor-β challenge.
[Acta Pharmacologica Sinica]
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Ma, S., Guo, Z., Liu, F., Hasan, S.-G., Yang, D., Tang, N., An, P., Wang, M., Wu, H., Yang, Z., Fan, D., & Tang, Q. (2021). 6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00587-z Cite
Scientists provided automated protocols for neuronal differentiation of neural progenitor cells in 2D culture and 3D midbrain organoids for high throughput screenings.
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Boussaad, I., Cruciani, G., Bolognin, S., Antony, P., Dording, C. M., Kwon, Y.-J., Heutink, P., Fava, E., Schwamborn, J. C., & Krüger, R. (2021). Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening. Scientific Reports, 11(1), 1439. https://doi.org/10.1038/s41598-021-81129-3 Cite
The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy]
Integrin α‐subunits were investigated systematically for their expression over the course of hepatic stellate cells activation and their distribution on fibroblasts and other systemic primary cells.
[Journal of Pathology]
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Nishimichi, N., Tsujino, K., Kanno, K., Sentani, K., Kobayashi, T., Chayama, K., Sheppard, D., & Yokosaki, Y. (n.d.). Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5618 Cite
Dermal fibroblasts (DF) are critical for effective wound healing, so the authors sought to establish whether there were any differences in DF cultured from Type 2 diabetes mellitus donors or those without diabetes.
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Al-Rikabi, A. H. A., Tobin, D. J., Riches-Suman, K., & Thornton, M. J. (2021). Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports, 11(1), 1474. https://doi.org/10.1038/s41598-020-80072-z Cite