Endothelial Dysfunction in Neuroprogressive Disorders- Causes and Suggested Treatments

On the basis of the above molecular mechanisms, details are given of potential treatment options for mitigating endothelial cell dysfunction and activation in neuroprogressive disorders.
[BMC Medicine]
Morris, G., Puri, B. K., Olive, L., Carvalho, A., Berk, M., Walder, K., Gustad, L. T., & Maes, M. (2020). Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments. BMC Medicine, 18(1), 305. https://doi.org/10.1186/s12916-020-01749-w Cite
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HOPS/Tmub1 Involvement in the NF-kB-Mediated Inflammatory Response Through the Modulation of TRAF6

The authors found that HOPS enhanced NF-κB activation leading to increase transcription of inflammatory mediators, through the reduction of IκBα stability.
[Cell Death & Disease]
HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6 | Cell Death & Disease. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41419-020-03086-5#Abs1 Cite
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Tenascin C Promotes Cancer Cell Plasticity in Mesenchymal Glioblastoma

Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.
[Oncogene]
Angel, I., Pilo Kerman, O., Rousso-Noori, L., & Friedmann-Morvinski, D. (2020). Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01506-6 Cite
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Mesenchymal Stem Cells Reverse EMT Process through Blocking the Activation of NF-κB and Hedgehog Pathways in LPS-Induced Acute Lung Injury

Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.
[Cell Death & Disease]
Xiao, K., He, W., Guan, W., Hou, F., Yan, P., Xu, J., Zhou, T., Liu, Y., & Xie, L. (2020). Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03034-3 Cite
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Engineered Cardiac Tissues: A Novel In Vitro Model to Investigate the Pathophysiology of Mouse Diabetic Cardiomyopathy

Researchers developed a murine-based engineered cardiac tissues (ECTs) model to investigate cardiac injury produced by advanced glycation end-products (AGEs). One findinf was that AGEs treatment significantly increased the markers of fibrosis (TGF-β, α-SMA, Ctgf, Collagen I-α1, Collagen III-α1, and Fn1) and hypertrophy.
[Acta Pharmacologica Sinica]
Wang, X., Chen, X., Yu, H., Tan, Y., Lin, Q., Keller, B. B., Zheng, Y., & Cai, L. (2020). Engineered cardiac tissues: a novel in vitro model to investigate the pathophysiology of mouse diabetic cardiomyopathy. Acta Pharmacologica Sinica, 1–10. https://doi.org/10.1038/s41401-020-00538-8 Cite
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Stroma-Derived ANGPTL2 Establishes an Anti-Tumor Microenvironment during Intestinal Tumorigenesis

ANGPTL2 secreted from intestinal subepithelial myofibroblasts drove generation of Ly6Chigh immunostimulatory macrophages via NF-κB signaling to promote CD4+ Th1 cell responses that established an anti-tumor microenvironment during injury-induced intestinal tumorigenesis
[Oncogene]
Horiguchi, H., Kadomatsu, T., Miyata, K., Terada, K., Sato, M., Torigoe, D., Morinaga, J., Moroishi, T., & Oike, Y. (2020). Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01505-7 Cite
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The ALPK1/TIFA/NF-κB Axis Links a Bacterial Carcinogen to R-Loop-Induced Replication Stress

DNA damage depended on the bi-functional RfaE enzyme and the Cag pathogenicity island of H. pylori, is accompanied by replication fork stalling and could be observed also in primary cells derived from gastric organoids.
[Nature Communications]
Bauer, M., Nascakova, Z., Mihai, A.-I., Cheng, P. F., Levesque, M. P., Lampart, S., Hurwitz, R., Pfannkuch, L., Dobrovolna, J., Jacobs, M., Bartfeld, S., Dohlman, A., Shen, X., Gall, A. A., Salama, N. R., Töpfer, A., Weber, A., Meyer, T. F., Janscak, P., & Müller, A. (2020). The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nature Communications, 11(1), 5117. https://doi.org/10.1038/s41467-020-18857-z Cite
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Pancreas-Specific Deletion of Protein Kinase D Attenuates Inflammation, Necrosis, and Severity of Acute Pancreatitis

Investigators generated a mouse model with pancreas-specific deletion of PKD3, the predominant PKD isoform in mouse pancreatic acinar cells, by crossing Pkd3flox/flox mice with Pdx1-Cre transgenic mice which express Cre recombinase under the control of the mouse Pdx1 promoter.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
Yuan, J., Chheda, C., Piplani, H., Geng, M., Tan, G., Thakur, R., & Pandol, S. J. (2020). Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 165987. https://doi.org/10.1016/j.bbadis.2020.165987 Cite
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B7-H3 Regulates KIF15-Activated ERK1/2 Pathway and Contributes to Radioresistance in Colorectal Cancer

In vitro and in vivo functional analyses showed that B7-H3 enhanced resistance against irradiation in colorectal cancer cells by upregulating KIF15 expression via NF-κB, which activated ERK1/2 signaling, a key pathway involved in radioresistance in cancers.
[Cell Death & Disease]
B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer | Cell Death & Disease. (n.d.). Retrieved October 6, 2020, from https://www.nature.com/articles/s41419-020-03041-4 Cite
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Parthenolide Promotes the Repair of Spinal Cord Injury by Modulating M1/M2 Polarization via the NF-κB and STAT 1/3 Signaling Pathway

Investigators showed that parthenolide could improve the functional recovery of spinal cord in mice as revealed by increased BMS scores and decreased cavity of spinal cord injury in vivo.
[Cell Death Discovery]
Gaojian, T., Dingfei, Q., Linwei, L., Xiaowei, W., Zheng, Z., Wei, L., Tong, Z., Benxiang, N., Yanning, Q., Wei, Z., & Jian, C. (2020). Parthenolide promotes the repair of spinal cord injury by modulating M1/M2 polarization via the NF-κB and STAT 1/3 signaling pathway. Cell Death Discovery, 6(1), 1–16. https://doi.org/10.1038/s41420-020-00333-8 Cite
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LncRNA-AK149641 Regulates the Secretion of Tumor Necrosis Factor-α in P815 Mast Cells by Targeting the Nuclear Factor-Kappa B Signaling Pathway

Scientists elucidated the function and possible role of a novel lncRNA, called lncRNA-AK149641, in the mechanism of lipopolysaccharide-induced inflammatory response in P815 mast cells.
[Scientific Reports]
Zhou, Y., Gu, L., Zhang, J., Pan, J., Zhang, J., Zhao, D., & Liu, F. (2020). LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway. Scientific Reports, 10(1), 16655. https://doi.org/10.1038/s41598-020-73186-x Cite
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