Epigallocatechin-3-Gallate Mobilizes Intracellular Ca2+ in Prostate Cancer Cells through Combined Ca2+ Entry and Ca2+-Induced Ca2+ Release

pigallocatechin-3-gallate (EGCG) induced an internal Ca2+ increase in prostate cancer (PCa) cells by a multi-step mechanism. Researchers confirmed the possibility of using EGCG as a synergistic adjuvant in combined therapies for recalcitrant malignancies like androgen-independent PCa.
[Life Sciences]
Marchetti, C., Gavazzo, P., & Burlando, B. (2020). Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release. Life Sciences, 258, 118232. https://doi.org/10.1016/j.lfs.2020.118232 Cite
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Hepatocellular Carcinoma-Derived High Mobility Group Box 1 Triggers M2 Macrophage Polarization via a TLR2/NOX2/Autophagy Axis

Scientists provide evidence to reveal that NADPH oxidase 2 (NOX2)-dependent reactive oxygen species generation is crucial for hepatocellular carcinoma -induced autophagy, NF-κB p65 down-regulation and M2 phenotype polarization in primary macrophages.
[Scientific Reports]
Shiau, D.-J., Kuo, W.-T., Davuluri, G. V. N., Shieh, C.-C., Tsai, P.-J., Chen, C.-C., Lin, Y.-S., Wu, Y.-Z., Hsiao, Y.-P., & Chang, C.-P. (2020). Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis. Scientific Reports, 10(1), 13582. https://doi.org/10.1038/s41598-020-70137-4 Cite
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Autophagy Protein ATG7 Is a Critical Regulator of Endothelial Cell Inflammation and Permeability

Scientists investigated the role of ATG7, an essential autophagy regulator with no autophagy-unrelated functions, in the mechanism of endothelial cell inflammation and permeability.
[Scientific Reports]
Shadab, M., Millar, M. W., Slavin, S. A., Leonard, A., Fazal, F., & Rahman, A. (2020). Autophagy protein ATG7 is a critical regulator of endothelial cell inflammation and permeability. Scientific Reports, 10(1), 13708. https://doi.org/10.1038/s41598-020-70126-7 Cite
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Neutrophil Extracellular Traps Amplify Neutrophil Recruitment and Inflammation in Neutrophilic Asthma by Stimulating the Airway Epithelial Cells to Activate the TLR4/NF-κB Pathway and Secrete Chemokines

Formation of neutrophil extracellular traps (NETs) and neutrophil swarming was seen in a mouse model of neutrophilic asthma. Additionally, NETs were found to stimulate airway cells to express CXCL1, CXCL2, and CXCL8 via the TLR4/NF-κB pathway, which recruits neutrophils to the inflammation site.
[Aging]
Aging | Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines - Full Text. (n.d.). Retrieved August 7, 2020, from https://www.aging-us.com/article/5f2427ad6c2ca900075aeb68/text Cite
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Chelerythrine Suppresses Proliferation and Metastasis of Human Prostate Cancer Cells via Modulating MMP/TIMP/NF-κB System

The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
Yang, B., Zhang, D., Qian, J., & Cheng, Y. (2020). Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-κB system. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03845-0 Cite
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Tonicity-Responsive Enhancer-Binding Protein Promotes Stemness of Liver Cancer and Cisplatin Resistance

Tonicity-responsive enhancer binding protein (TonEBP) was required for the tumorigenesis and self-renewal of liver CSCs. Cisplatin induced the recruitment of the ERCC1/XPF dimer to the chromatin in a TonEBP-dependent manner leading to DNA repair and cisplatin resistance.
[Ebiomedicine]
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

The authors identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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NF-κB-Dependent miR-31/155 Biogenesis Is Essential for TNF-α-Induced Impairment of Endothelial Progenitor Cell Function

Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia.
[Experimental and Molecular Medicine]
Kim, J.-H., Kim, J.-Y., Park, M., Kim, S., Kim, T., Kim, J., Choi, S., Park, W., Hwang, J. Y., Choe, J., Ha, K.-S., Won, M.-H., Ryoo, S., Kwon, Y.-G., & Kim, Y.-M. (2020). NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0478-x Cite
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The Prostaglandin Synthases, COX-2 and L-PGDS, Mediate Prostate Hyperplasia Induced by Low-Dose Bisphenol A

In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
[Scientific Reports]
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Dental Follicle Stem Cells Rescue the Regenerative Capacity of Inflamed Rat Dental Pulp through a Paracrine Pathway

Researchers focused on the paracrine effects of rat dental follicle stem cells (DFSCs) on the inflammation and regeneration of rat injured dental pulp to detect whether DFSCs are a potential candidate for mesenchymal stem cell-based minimally invasive vital pulp therapy.
[Stem Cell Research & Therapy]
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IL-17F Induces Inflammation, Dysfunction and Cell Death in Mouse Islets

IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
[Scientific Reports]
Catterall, T., Fynch, S., Kay, T. W. H., Thomas, H. E., & Sutherland, A. P. R. (2020). IL-17F induces inflammation, dysfunction and cell death in mouse islets. Scientific Reports, 10(1), 13077. https://doi.org/10.1038/s41598-020-69805-2 Cite
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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