pigallocatechin-3-gallate (EGCG) induced an internal Ca2+ increase in prostate cancer (PCa) cells by a multi-step mechanism. Researchers confirmed the possibility of using EGCG as a synergistic adjuvant in combined therapies for recalcitrant malignancies like androgen-independent PCa.
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Scientists provide evidence to reveal that NADPH oxidase 2 (NOX2)-dependent reactive oxygen species generation is crucial for hepatocellular carcinoma -induced autophagy, NF-κB p65 down-regulation and M2 phenotype polarization in primary macrophages.
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Shiau, D.-J., Kuo, W.-T., Davuluri, G. V. N., Shieh, C.-C., Tsai, P.-J., Chen, C.-C., Lin, Y.-S., Wu, Y.-Z., Hsiao, Y.-P., & Chang, C.-P. (2020). Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis. Scientific Reports, 10(1), 13582. https://doi.org/10.1038/s41598-020-70137-4 Cite
Scientists investigated the role of ATG7, an essential autophagy regulator with no autophagy-unrelated functions, in the mechanism of endothelial cell inflammation and permeability.
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Formation of neutrophil extracellular traps (NETs) and neutrophil swarming was seen in a mouse model of neutrophilic asthma. Additionally, NETs were found to stimulate airway cells to express CXCL1, CXCL2, and CXCL8 via the TLR4/NF-κB pathway, which recruits neutrophils to the inflammation site.
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Aging | Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines - Full Text. (n.d.). Retrieved August 7, 2020, from https://www.aging-us.com/article/5f2427ad6c2ca900075aeb68/text Cite
Continue reading “Neutrophil Extracellular Traps Amplify Neutrophil Recruitment and Inflammation in Neutrophilic Asthma by Stimulating the Airway Epithelial Cells to Activate the TLR4/NF-κB Pathway and Secrete Chemokines”
The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
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Tonicity-responsive enhancer binding protein (TonEBP) was required for the tumorigenesis and self-renewal of liver CSCs. Cisplatin induced the recruitment of the ERCC1/XPF dimer to the chromatin in a TonEBP-dependent manner leading to DNA repair and cisplatin resistance.
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The authors identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia.
[Experimental and Molecular Medicine]
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Kim, J.-H., Kim, J.-Y., Park, M., Kim, S., Kim, T., Kim, J., Choi, S., Park, W., Hwang, J. Y., Choe, J., Ha, K.-S., Won, M.-H., Ryoo, S., Kwon, Y.-G., & Kim, Y.-M. (2020). NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0478-x Cite
In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
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Researchers focused on the paracrine effects of rat dental follicle stem cells (DFSCs) on the inflammation and regeneration of rat injured dental pulp to detect whether DFSCs are a potential candidate for mesenchymal stem cell-based minimally invasive vital pulp therapy.
[Stem Cell Research & Therapy]
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IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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