On the basis of the above molecular mechanisms, details are given of potential treatment options for mitigating endothelial cell dysfunction and activation in neuroprogressive disorders.
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The authors found that HOPS enhanced NF-κB activation leading to increase transcription of inflammatory mediators, through the reduction of IκBα stability.
[Cell Death & Disease]
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HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6 | Cell Death & Disease. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41419-020-03086-5#Abs1 Cite
Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.
Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.
[Cell Death & Disease]
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Xiao, K., He, W., Guan, W., Hou, F., Yan, P., Xu, J., Zhou, T., Liu, Y., & Xie, L. (2020). Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03034-3 Cite
Researchers developed a murine-based engineered cardiac tissues (ECTs) model to investigate cardiac injury produced by advanced glycation end-products (AGEs). One findinf was that AGEs treatment significantly increased the markers of fibrosis (TGF-β, α-SMA, Ctgf, Collagen I-α1, Collagen III-α1, and Fn1) and hypertrophy.
[Acta Pharmacologica Sinica]
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ANGPTL2 secreted from intestinal subepithelial myofibroblasts drove generation of Ly6Chigh immunostimulatory macrophages via NF-κB signaling to promote CD4+ Th1 cell responses that established an anti-tumor microenvironment during injury-induced intestinal tumorigenesis
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DNA damage depended on the bi-functional RfaE enzyme and the Cag pathogenicity island of H. pylori, is accompanied by replication fork stalling and could be observed also in primary cells derived from gastric organoids.
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Bauer, M., Nascakova, Z., Mihai, A.-I., Cheng, P. F., Levesque, M. P., Lampart, S., Hurwitz, R., Pfannkuch, L., Dobrovolna, J., Jacobs, M., Bartfeld, S., Dohlman, A., Shen, X., Gall, A. A., Salama, N. R., Töpfer, A., Weber, A., Meyer, T. F., Janscak, P., & Müller, A. (2020). The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nature Communications, 11(1), 5117. https://doi.org/10.1038/s41467-020-18857-z Cite
Investigators generated a mouse model with pancreas-specific deletion of PKD3, the predominant PKD isoform in mouse pancreatic acinar cells, by crossing Pkd3flox/flox mice with Pdx1-Cre transgenic mice which express Cre recombinase under the control of the mouse Pdx1 promoter.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
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Yuan, J., Chheda, C., Piplani, H., Geng, M., Tan, G., Thakur, R., & Pandol, S. J. (2020). Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 165987. https://doi.org/10.1016/j.bbadis.2020.165987 Cite
In vitro and in vivo functional analyses showed that B7-H3 enhanced resistance against irradiation in colorectal cancer cells by upregulating KIF15 expression via NF-κB, which activated ERK1/2 signaling, a key pathway involved in radioresistance in cancers.
[Cell Death & Disease]
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B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer | Cell Death & Disease. (n.d.). Retrieved October 6, 2020, from https://www.nature.com/articles/s41419-020-03041-4 Cite
Investigators showed that parthenolide could improve the functional recovery of spinal cord in mice as revealed by increased BMS scores and decreased cavity of spinal cord injury in vivo.
[Cell Death Discovery]
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Gaojian, T., Dingfei, Q., Linwei, L., Xiaowei, W., Zheng, Z., Wei, L., Tong, Z., Benxiang, N., Yanning, Q., Wei, Z., & Jian, C. (2020). Parthenolide promotes the repair of spinal cord injury by modulating M1/M2 polarization via the NF-κB and STAT 1/3 signaling pathway. Cell Death Discovery, 6(1), 1–16. https://doi.org/10.1038/s41420-020-00333-8 Cite
Scientists elucidated the function and possible role of a novel lncRNA, called lncRNA-AK149641, in the mechanism of lipopolysaccharide-induced inflammatory response in P815 mast cells.
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Zhou, Y., Gu, L., Zhang, J., Pan, J., Zhang, J., Zhao, D., & Liu, F. (2020). LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway. Scientific Reports, 10(1), 16655. https://doi.org/10.1038/s41598-020-73186-x Cite