Bacainn Therapeutics Reports Positive Topline Results from Phase I Study of BT051, a Novel Therapeutic Approach to Treat Inflammatory Diseases Such As Ulcerative Colitis

Bacainn Therapeutics, Inc. announced the successful completion of the company’s Phase I, first-in-human clinical trial of BT051, a novel, orally administered, gut-selective inhibitor of migration and activation of neutrophils.
[Bacainn Therapeutics, Inc. (Business Wire, Inc.)]
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The Melanoma Brain Metastatic Microenvironment: Aldolase C Partakes in Shaping the Malignant Phenotype of Melanoma Cells – A Case of Inter-Tumor Heterogeneity

Researchers used brain metastasizing variants from three human melanomas to explore the functional role of Aldolase C in the formation and maintenance of melanoma brain metastasis.
[Molecular Oncology]
Izraely, S., Ben‐Menachem, S., Sagi‐Assif, O., Meshel, T., Malka, S., Telerman, A., Bustos, M. A., Ramos, I. R., Pasmanik‐Chor, M., Hoon, D. S. B., & Witz, I. P. (n.d.). The melanoma brain metastatic microenvironment: Aldolase C partakes in shaping the malignant phenotype of melanoma cells - A case of inter-tumor heterogeneity. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12872 Cite
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Generation of Immune Cell Containing Adipose Organoids for In Vitro Analysis of Immune Metabolism

Scientists created the first 3D adipose tissue organoid model which could contain and maintain resident immune cell populations of the stromal vascular fraction and proved to be effective in studying adipose tissue biology in a convenient manner.
[Scientific Reports]
Taylor, J., Sellin, J., Kuerschner, L., Krähl, L., Majlesain, Y., Förster, I., Thiele, C., Weighardt, H., & Weber, E. (2020). Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism. Scientific Reports, 10(1), 21104. https://doi.org/10.1038/s41598-020-78015-9 Cite
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Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Scientists summarize the known ultrastructural, molecular, and functional features of direct microglia-neuron interactions and their roles in brain disease.
[Neuron]
Cserép, C., Pósfai, B., & Dénes, Á. (2020). Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2020.11.007 Cite
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Generation of Immune Cell Containing Adipose Organoids for In Vitro Analysis of Immune Metabolism

Scientists created the first 3D adipose tissue organoid model which could contain and maintain resident immune cell populations of the stromal vascular fraction and proved to be effective in studying adipose tissue biology in a convenient manner.
[Scientific Reports]
Taylor, J., Sellin, J., Kuerschner, L., Krähl, L., Majlesain, Y., Förster, I., Thiele, C., Weighardt, H., & Weber, E. (2020). Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism. Scientific Reports, 10(1), 21104. https://doi.org/10.1038/s41598-020-78015-9 Cite
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Soluble VCAM-1 Promotes Gemcitabine Resistance via Macrophage Infiltration and Predicts Therapeutic Response in Pancreatic Cancer

Subcutaneous allograft tumors with overexpression or knock-down of vascular cell adhesion molecule-1 (VCAM-1), as well as VCAM-1-blocking treatment in the spontaneous mouse model of pancreatic cancer, revealed that sVCAM-1 promotes tumor growth and resistance to gemcitabine treatment in vivo but not in vitro.
[Scientific Reports]
Takahashi, R., Ijichi, H., Sano, M., Miyabayashi, K., Mohri, D., Kim, J., Kimura, G., Nakatsuka, T., Fujiwara, H., Yamamoto, K., Kudo, Y., Tanaka, Y., Tateishi, K., Nakai, Y., Morishita, Y., Soma, K., Takeda, N., Moses, H. L., Isayama, H., & Koike, K. (2020). Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer. Scientific Reports, 10(1), 21194. https://doi.org/10.1038/s41598-020-78320-3 Cite
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Human Amniotic Membrane-Mesenchymal Stem Cells-Conditioned Medium Reduces Inflammatory Factors and Fibrosis in Ovalbumin-Induced Asthma in Mice

Investigators examined the effects of human amniotic membrane MSCs‐conditioned medium on ovalbumin (OVA)‐induced asthma. 48 hours after the last challenge, serum and bronchoalveolar lavage fluid samples were collected and used for evaluation of inflammatory factors and cells, respectively.
[Experimental Physiology]
Dalouchi, F., Falak, R., Bakhshesh, M., Aghdam, Z. S., Azizi, Y., & Aboutaleb, N. (n.d.). Human amniotic membrane-mesenchymal stem cells-conditioned medium reduces inflammatory factors and fibrosis in ovalbumin-induced asthma in mice. Experimental Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1113/EP088911 Cite
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Multi-Modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

Scientists analyzed compositional and transcriptional changes of the brain immune landscape in response to aging and gut dysbiosis.
[Cell Reports]
Golomb, S. M., Guldner, I. H., Zhao, A., Wang, Q., Palakurthi, B., Aleksandrovic, E. A., Lopez, J. A., Lee, S. W., Yang, K., & Zhang, S. (2020). Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis. Cell Reports, 33(9). https://doi.org/10.1016/j.celrep.2020.108438 Cite
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Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

To generate spatially-resolved tumor and immune cell data at single cell resolution, investigators developed two quantitative multiplex immunofluorescence assays to interrogate myeloid cells and macrophages in the pancreatic ductal carcinoma tumor microenvironment.
[Clinical Cancer Research]
Väyrynen, S. A., Zhang, J., Yuan, C., Väyrynen, J. P., Costa, A. D., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L. K., Reilly, E., Rahma, O. E., Clancy, T. E., Wang, J., … Wolpin, B. M. (2020). Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3141 Cite
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Immunological Mechanisms and Therapeutic Targets of Fatty Liver Diseases

Scientists review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation associated with fatty liver diseases and the differences in the progression of alcoholic liver disease and nonalcoholic fatty liver disease. Multiple cell types in the liver, including macrophages, neutrophils, other immune cell types and hepatocytes, are involved in fatty liver disease inflammation.
[Cellular & Molecular Immunology]
Wang, H., Mehal, W., Nagy, L. E., & Rotman, Y. (2020). Immunological mechanisms and therapeutic targets of fatty liver diseases. Cellular & Molecular Immunology, 1–19. https://doi.org/10.1038/s41423-020-00579-3 Cite
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Macrophage-Derived Small Extracellular Vesicles Promote Biomimetic Mineralized Collagen-Mediated Endogenous Bone Regeneration

Researchers evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated MSC osteogenesis through the Smad/1/5/9 pathway.
[International Journal of Oral Science]
Liu, A., Jin, S., Fu, C., Cui, S., Zhang, T., Zhu, L., Wang, Y., Shen, S. G. F., Jiang, N., & Liu, Y. (2020). Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-00100-6 Cite
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