Tag Archives: myeloid cells

Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine]
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Cryopreservation of Unrelated Donor Hematopoietic Stem Cells: The Right Answer for Transplantations during the COVID-19 Pandemic?

Investigators compared 32 patients who underwent unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period.
[Bone Marrow Transplantation]
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Blocking Siglec-10hi Tumor-Associated Macrophages Improves Anti-Tumor Immunity and Enhances Immunotherapy for Hepatocellular Carcinoma

Immunohistochemistry and flow cytometry were performed to detect the characteristics of sialic acid-binding immunoglobulin-like lectin 10high (Siglec-10hi) tumor-associated macrophages and explore their impact on the tumor microenvironment of hepatocellular carcinoma.
[Experimental Hematology & Oncology]
Xiao, N., Zhu, X., Li, K., Chen, Y., Liu, X., Xu, B., Lei, M., Xu, J., & Sun, H.-C. (2021). Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma. Experimental Hematology & Oncology, 10(1), 36. https://doi.org/10.1186/s40164-021-00230-5 Cite
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Human Oral Mucosa Cell Atlas Reveals a Stromal-Neutrophil Axis Regulating Tissue Immunity

To aid in understanding tissue-specific pathophysiology, researchers compiled a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis.
[Cell]
Williams, D. W., Greenwell-Wild, T., Brenchley, L., Dutzan, N., Overmiller, A., Sawaya, A. P., Webb, S., Martin, D., Hajishengallis, G., Divaris, K., Morasso, M., Haniffa, M., & Moutsopoulos, N. M. (2021). Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.05.013 Cite
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TAM Kinase Signaling Is Indispensable for Proper Skeletal Muscle Regeneration in Mice

The authors investigated the involvement of TAM receptor kinases Mer and Axl in the muscle regeneration process by studying the muscle repair following cardiotoxin-induced injury in Mer−/− mice.In vitro inhibition of TAM kinase signaling in C2C12 myoblasts resulted in decreased viability and in impaired myotube growth.
[Cell Death & Disease]
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Inflammation, Infection and Venous Thromboembolism

Scientists discuss the contributions of inflammation and infection to venous thromboembolism.
[Circulation Research]
Colling, M. E., Tourdot, B. E., & Kanthi, Y. (2021). Inflammation, Infection and Venous Thromboembolism. Circulation Research, 128(12), 2017–2036. https://doi.org/10.1161/CIRCRESAHA.121.318225 Cite
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Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T Cell Immunity

The authors showed that metastatic disease in the pleural and peritoneal cavities is associated with poor clinical outcomes after immune checkpoint blockade therapy.
[Cancer Cell]
Chow, A., Schad, S., Green, M. D., Hellmann, M. D., Allaj, V., Ceglia, N., Zago, G., Shah, N. S., Sharma, S. K., Mattar, M., Chan, J., Rizvi, H., Zhong, H., Liu, C., Bykov, Y., Zamarin, D., Shi, H., Budhu, S., Wohlhieter, C., … Merghoub, T. (2021). Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.05.006 Cite
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Monocyte Metabolic Transcriptional Programs Associate with Resistance to Tuberculin Skin Test/Interferon-γ Release Assay Conversion

To identify mechanisms of resistance to Mycobacterium tuberculosis (Mtb) infection, scientists compared transcriptional profiles from highly-exposed contacts who resist tuberculin skin test/interferon-γ release assay conversion and controls with latent Mtb infection using RNAseq.
[Journal of Clinical Investigation]
Simmons, J. D., Van, P. T., Stein, C. M., Chihota, V., Ntshiqa, T., Maenetje, P., Peterson, G. J., Reynolds, A., Benchek, P., Velen, K., Fielding, K. L., Grant, A. D., Graustein, A. D., Nguyen, F. K., Seshadri, C., Gottardo, R., Mayanja-Kizza, H., Wallis, R. S., Churchyard, G., … Hawn, T. R. (2021). Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140073 Cite
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Neutrophil Extracellular Traps Impair Intestinal Barrier Functions in Sepsis by Regulating TLR9-Mediated Endoplasmic Reticulum Stress Pathway

Neutrophil extracellular traps treatment induced intestinal epithelial monolayer barrier disruption and endoplasmic reticulum (ER) stress activation in a dose-dependent manner in vitro, and ER stress inhibition markedly attenuated intestinal apoptosis and tight junction injury.
[Cell Death & Disease]
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Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
[Clinical Cancer Research]
Carter, J. M., Polley, M.-Y. C., Leon-Ferre, R. A., Sinnwell, J., Thompson, K. J., Wang, X., Ma, Y., Zahrieh, D., Kachergus, J. M., Solanki, M., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Thompson, E. A., & Goetz, M. P. (2021). Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0343 Cite
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VISTA Is an Activating Receptor in Human Monocytes

The authors discovered two novel V-domain Ig suppressor of T cell activation (VISTA) antibodies and characterized their effects on human peripheral blood mononuclear cells by scRNA/CITE-seq.
[Journal of Experimental Medicine]
Rogers, B. M., Smith, L., Dezso, Z., Shi, X., DiGiammarino, E., Nguyen, D., Sethuraman, S., Zheng, P., Choi, D., Zhang, D., Nguyen, A., McGuire, K., Liu, W., Chung, N., Chao, D. T., Ye, S., & Starbeck-Miller, G. R. (2021). VISTA is an activating receptor in human monocytes. Journal of Experimental Medicine, 218(8). https://doi.org/10.1084/jem.20201601 Cite
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