Proliferation Tracing Reveals Regional Hepatocyte Generation in Liver Homeostasis and Repair

Cell proliferation tracing revealed that, at the whole hepatocyte–population level, more proliferation was detected in a subset of midzonal hepatocytes during liver homeostasis, with less proliferation in periportal hepatocytes and minimal proliferation in pericentral hepatocytes.
[Science]
He, L., Pu, W., Liu, X., Zhang, Z., Han, M., Li, Y., Huang, X., Han, X., Li, Y., Liu, K., Shi, M., Lai, L., Sun, R., Wang, Q.-D., Ji, Y., Tchorz, J. S., & Zhou, B. (2021). Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science, 371(6532). https://doi.org/10.1126/science.abc4346 Cite
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Network Models of Primary Melanoma Microenvironments Identify Key Melanoma Regulators Underlying Prognosis

Seventeen key drivers of the gene subnetworks associated with poor prognosis, including the transcription factor ZNF180, are tested for their pro-tumorigenic effects in vitro. The anti-tumor effect of silencing ZNF180 is further validated using in vivo xenografts.
[Nature Communications]
Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis | Nature Communications. (n.d.). Retrieved March 1, 2021, from https://www.nature.com/articles/s41467-021-21457-0 Cite
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Injectable Hydrogel with MSNs/microRNA-21-5p Delivery Enables Both Immunomodification and Enhanced Angiogenesis for Myocardial Infarction Therapy in Pigs

Scientists developed a microRNA-21-5p delivery system using functionalized mesoporous silica nanoparticles with additional intrinsic therapeutic effects.
[Science Advances]
Li, Y., Chen, X., Jin, R., Chen, L., Dang, M., Cao, H., Dong, Y., Cai, B., Bai, G., Gooding, J. J., Liu, S., Zou, D., Zhang, Z., & Yang, C. (2021). Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Science Advances, 7(9), eabd6740. https://doi.org/10.1126/sciadv.abd6740 Cite
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Single-Cell Transcriptomic Profiling and Characterization of Endothelial Progenitor Cells: New Approach for Finding Novel Markers

Scientists assembled five groups of chosen endothelial progenitor cells (EPCs)-related genes/factors using PubMed literature and Gene Ontology databases. This shortened database of EPC factors was fed into publically published transcriptome matrix to compare their expression between endothelial colony-forming cells, HUVECs, and two adult endothelial cell types from the skin and adipose tissue.
[Stem Cell Research & Therapy]
Abdelgawad, M. E., Desterke, C., Uzan, G., & Naserian, S. (2021). Single-cell transcriptomic profiling and characterization of endothelial progenitor cells: new approach for finding novel markers. Stem Cell Research & Therapy, 12(1), 145. https://doi.org/10.1186/s13287-021-02185-0 Cite
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Jubilant Therapeutics Announces Research Collaboration with Boston Children’s Hospital, Harvard Medical School, to Evaluate PAD4 Inhibitors in Autoimmune/Inflammation Disease Models

Jubilant Therapeutics Inc. announced a collaboration with Boston Children’s Hospital to evaluate peptidyl arginine deiminase 4 (PAD4) inhibitors under development by Jubilant Therapeutics to explore the modulation of neutrophil extracellular traps in preclinical models of neutrophil regulation and rheumatoid arthritis.
[Jubilant Therapeutics Inc.]
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Sialic Acids in Pancreatic Cancer Cells Drive Tumor-Associated Macrophage Differentiation via the Siglec Receptors Siglec-7 and Siglec-9

Researchers showed that PDAC tumor cells present an increased sialylation that could be recognized by Siglec-7 and Siglec-9 on myeloid cells.
[Nature Communications]
Rodriguez, E., Boelaars, K., Brown, K., Eveline Li, R. J., Kruijssen, L., Bruijns, S. C. M., van Ee, T., Schetters, S. T. T., Crommentuijn, M. H. W., van der Horst, J. C., van Grieken, N. C. T., van Vliet, S. J., Kazemier, G., Giovannetti, E., Garcia-Vallejo, J. J., & van Kooyk, Y. (2021). Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nature Communications, 12(1), 1270. https://doi.org/10.1038/s41467-021-21550-4 Cite
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Large‐Scale Generation of Megakaryocytes from Human Embryonic Stem Cells Using Transgene‐Free and Stepwise Defined Suspension Culture Conditions

Scientists defined an optimal, stepwise and completely xeno‐free culture protocol for the generation of megakaryocytes from human embryonic stem cells.
[Cell Proliferation]
Zhang, B., Wu, X., Zi, G., He, L., Wang, S., Chen, L., Fan, Z., Nan, X., Xi, J., Yue, W., Wang, L., Wang, L., Hao, J., Pei, X., & Li, Y. (n.d.). Large-scale generation of megakaryocytes from human embryonic stem cells using transgene-free and stepwise defined suspension culture conditions. Cell Proliferation, n/a(n/a), e13002. https://doi.org/https://doi.org/10.1111/cpr.13002 Cite
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Gene Deconvolution Reveals Aberrant Liver Regeneration and Immune Cell Infiltration in Alcohol-Associated Hepatitis

Investigators combined single‐cell RNA‐seq data from healthy livers and peripheral immune cells to measure cell proportions in chronic liver diseases.
[Hepatology]
Kim, A., Wu, X., Allende, D. S., & Nagy, L. E. (n.d.). Gene deconvolution reveals aberrant liver regeneration and immune cell infiltration in alcohol-associated hepatitis. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31759 Cite
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Loss of NPC1 Enhances Phagocytic Uptake and Impairs Lipid Trafficking in Microglia

Loss of NPC1 triggered enhanced phagocytic uptake and impaired myelin turnover in microglia that precede neuronal death.
[Nature Communications]
Colombo, A., Dinkel, L., Müller, S. A., Sebastian Monasor, L., Schifferer, M., Cantuti-Castelvetri, L., König, J., Vidatic, L., Bremova-Ertl, T., Lieberman, A. P., Hecimovic, S., Simons, M., Lichtenthaler, S. F., Strupp, M., Schneider, S. A., & Tahirovic, S. (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), 1158. https://doi.org/10.1038/s41467-021-21428-5 Cite
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HIF2α is a Direct Regulator of Neutrophil Motility

Scientists revealed that activation of the Hypoxia Inducible Factor-2 (HIF2α) due to deficiency of HIF-prolyl hydroxylase domain protein-2 boosts neutrophil migration specifically through highly confined microenvironments.
[Blood]
Sormendi, S., Deygas, M., Sinha, A., Bernard, M. L. M., Krüger, A., Koutzelis, I., Le Lay, G. M., Sáez, P. J., Gerlach, M., Franke, K., Meneses, A., Kräter, M., Palladini, A., Guck, J., Coskun, Ü., Chavakis, T., Vargas, P., & Wielockx, B. (2021). HIF2α is a Direct Regulator of Neutrophil Motility. Blood, blood.2020007505. https://doi.org/10.1182/blood.2020007505 Cite
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Targeting Tumor-Associated Macrophages to Synergize Tumor Immunotherapy

Scientists summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies.
[Signal Transduction and Targeted Therapy]
Xiang, X., Wang, J., Lu, D., & Xu, X. (2021). Targeting tumor-associated macrophages to synergize tumor immunotherapy. Signal Transduction and Targeted Therapy, 6(1), 1–12. https://doi.org/10.1038/s41392-021-00484-9 Cite
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