Bioengineered In Vitro 3D Model of Myotonic Dystrophy Type 1 Human Skeletal Muscle

Biofabrication tools can be applied to engineer human three-dimensional culture systems that complement current preclinical research models. Investigators described the development of the first in vitro three-dimensional model of myotonic dystrophy type 1 human skeletal muscle.
[Biofabrication]
Fernández-Garibay, X., Ortega, M. A., Cerro-Herreros, E., Comelles, J., Martínez, E., Artero, R., Fernandez-Costa, J. M., & Ramon, J. (2021). Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle. Biofabrication. https://doi.org/10.1088/1758-5090/abf6ae Cite
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Human Anogenital Monocyte-Derived Dendritic Cells and langerin+cDC2 Are Major HIV Target Cells

Scientsts showed that HIV could penetrate the epithelial surface to interact with sub-epithelial resident mononuclear phagocytes in anogenital explants and defined the full array of subsets that were present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission.
[Nature Communications]
Rhodes, J. W., Botting, R. A., Bertram, K. M., Vine, E. E., Rana, H., Baharlou, H., Vegh, P., O’Neil, T. R., Ashhurst, A. S., Fletcher, J., Parnell, G. P., Graham, J. D., Nasr, N., Lim, J. J. K., Barnouti, L., Haertsch, P., Gosselink, M. P., Di Re, A., Reza, F., … Harman, A. N. (2021). Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells. Nature Communications, 12(1), 2147. https://doi.org/10.1038/s41467-021-22375-x Cite
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Eotaxin-1/CCL11 Is Involved in Cell Migration in Rheumatoid Arthritis

The authors investigated the expression and function of Eotaxin-1 (CCL11) in rheumatoid arthritis fibroblast-like synoviocytes.
[Scientific Reports]
Wakabayashi, K., Isozaki, T., Tsubokura, Y., Fukuse, S., & Kasama, T. (2021). Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. Scientific Reports, 11(1), 7937. https://doi.org/10.1038/s41598-021-87199-7 Cite
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Neutrophil Subtypes Shape HIV-Specific CD8 T-cell Responses after Vaccinia Virus Infection

Scientists found that these neutrophil subtypes showed distinct migratory and motility patterns and different ability to interact with CD8 T cells in the spleen following vaccinia virus infection.
[npj Vaccines]
Di Pilato, M., Palomino-Segura, M., Mejías-Pérez, E., Gómez, C. E., Rubio-Ponce, A., D’Antuono, R., Pizzagalli, D. U., Pérez, P., Kfuri-Rubens, R., Benguría, A., Dopazo, A., Ballesteros, I., Sorzano, C. O. S., Hidalgo, A., Esteban, M., & Gonzalez, S. F. (2021). Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection. Npj Vaccines, 6(1), 1–11. https://doi.org/10.1038/s41541-021-00314-7 Cite
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Control of IFN-I Responses by the Aminopeptidase IRAP in Neonatal C57BL/6 Alveolar Macrophages during RSV Infection

Neonatal C57BL/6 alveolar macrophages mobilized very weakly the IFN-I pathway upon Respiratory Syncytial Virus (RSV) infection in vitro and failed to restrain virus replication.
[Mucosal Immunology]
Drajac, C., Laubreton, D., Marquant, Q., Chottin, C., Ferret, C., Bouguyon, E., Schwartz-Cornil, I., Saveanu, L., Riffault, S., & Descamps, D. (2021). Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection. Mucosal Immunology, 1–14. https://doi.org/10.1038/s41385-021-00402-w Cite
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Therapeutic B-Cell Depletion Reverses Progression of Alzheimer’s Disease

Using three different murine transgenic models, scientists provide counterintuitive evidence that the Alzheimer’s disease progression required B cells.
[Nature Communications]
Kim, K., Wang, X., Ragonnaud, E., Bodogai, M., Illouz, T., DeLuca, M., McDevitt, R. A., Gusev, F., Okun, E., Rogaev, E., & Biragyn, A. (2021). Therapeutic B-cell depletion reverses progression of Alzheimer’s disease. Nature Communications, 12(1), 2185. https://doi.org/10.1038/s41467-021-22479-4 Cite
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The IRENA lncRNA Converts Chemotherapy-Polarized Tumor-Suppressing Macrophages to Tumor-Promoting Phenotypes in Breast Cancer

Scientists found that IFN-activated proinflammatory macrophages after neoadjuvant chemotherapy enhanced antitumor immunity but promoted cancer chemoresistance.
[Nature Cancer]
Liu, J., Lao, L., Chen, J., Li, J., Zeng, W., Zhu, X., Li, J., Chen, X., Yang, L., Xing, Y., Chen, F., Huang, D., Zhang, X., Wei, W., Gong, C., Huang, S., Yu, Z., Li, Z., Yang, L., … Song, E. (2021). The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer. Nature Cancer, 1–17. https://doi.org/10.1038/s43018-021-00196-7 Cite
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Anti-CLL1 Chimeric Antigen Receptor T Cell Therapy in Children with Relapsed/Refractory Acute Myeloid Leukemia

Scientists tested the safety and efficacy of chimeric antigen receptor T cell therapy in refractory/relapsed acute myeloid leukemia .
[Clinical Cancer Research]
Zhang, H., Wang, P., Li, Z., He, Y., Gan, W., & Jiang, H. (2021). Anti-CLL1 chimeric antigen receptor T cell therapy in children with relapsed/refractory acute myeloid leukemia. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4543 Cite
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Mutant KRAS Triggers Functional Reprogramming of Tumor-Associated Macrophages in Colorectal Cancer

Mutationally activated KRAS in tumor cells reprograms macrophages to a tumor-associated macrophage-like phenotype via a combination effect of tumor-derived CSF2 and lactate.
[Signal Transduction and Targeted Therapy]
Liu, H., Liang, Z., Zhou, C., Zeng, Z., Wang, F., Hu, T., He, X., Wu, X., Wu, X., & Lan, P. (2021). Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00534-2 Cite
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Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro

Guava seed polysaccharides (GSPS), GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy.
[International Journal of Molecular Sciences]
Lin, H.-C., & Lin, J.-Y. (2021). Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro. International Journal of Molecular Sciences, 22(7), 3631. https://doi.org/10.3390/ijms22073631 Cite
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CD47-Mediated Hedgehog/SMO/GLI1 Signaling Promotes Mesenchymal Stem Cell Immunomodulation in Mouse Liver Inflammation

Investigators found that mesenchymal stem cell CD47 and macrophage signal regulatory protein alpha expression were increased after LPS stimulation.
[Hepatology]
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