breast cancer cells

[Scientific Reports] Scientists performed immune profiling to compare immune-related gene expression between ductal carcinoma in situ and invasive carcinoma of the breast using nCounter PanCancer immune Profiling Panel and found that CXCL10 was the most significant gene that had the highest difference in expression between them.

[Science Translational Medicine] Researchers showed that patients with breast cancer did not accumulate sufficient intratumoral paclitaxel to induce mitotic arrest in tumor cells. Instead, clinically relevant concentrations induced multipolar mitotic spindle formation.

[Open Biology] To identify novel small molecules that inhibit microtubule organization, investigators conducted sequential phenotypic screening of fission yeast and human cells and showed that one of the compounds, L1, bound to the colchicine-binding site of microtubules and exhibited a preferential potency against a panel of human breast cancer cell lines compared with a control non-cancer cell line.

[Breast Cancer Research] By knocking down the expression of TAZ in TNBC cells, researchers found that TAZ is essential for the maintenance of telomeres in TNBC cells and that loss of TAZ caused senescence phenotype of TNBC cells.

[Journal of Antibiotics] Arthrifuranone A was isolation from an EtOAc-extract of Arthrinium pseudosinense culture medium and evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells.

[Journal of Bone and Mineral Research] In estrogen receptor positive (ER+) cells, oncostatin M (OSM) robustly stimulated phosphorylation of known gp130 signaling targets STAT3, ERK and AKT, while CNTF activated STAT3 signaling. In ER- breast cancer cells, OSM alone stimulated AKT and ERK signaling.