gp130 Cytokines Activate Novel Signaling Pathways and Alter Bone Dissemination in ER⁺ Breast Cancer Cells

In estrogen receptor positive (ER+) cells, oncostatin M (OSM) robustly stimulated phosphorylation of known gp130 signaling targets STAT3, ERK and AKT, while CNTF activated STAT3 signaling. In ER– breast cancer cells, OSM alone stimulated AKT and ERK signaling.