Inhibition of STAT3 Prevents Bone Metastatic Progression of Prostate Cancer In Vivo

Effects of signal transducer and activator of transcription 3 (STAT3) inhibitors, Stattic and Napabucasin, on metastatic potential in prostate cancer cells were studied in vitro by assessment of migration capacity, self‐renewal potential, and tumorsphere formation.
[Prostate]
Thulin, M. H., Määttä, J., Linder, A., Sterbova, S., Ohlsson, C., Damber, J.-E., Widmark, A., & Persson, E. (n.d.). Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24125 Cite
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Synergistic Effect of the TLR5 Agonist CBLB502 and Its Downstream Effector IL-22 against Liver Injury

Scientists investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
[Cell Death & Disease]
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Hypoxic Glioma-Derived Exosomes Promote M2-Like Macrophage Polarization by Enhancing Autophagy Induction

The authors investigated the effects of glioma-derived exosomes on autophagy, the polarization of tumor-associated macrophages, and glioma progression.
[Cell Death & Disease]
Xu, J., Zhang, J., Zhang, Z., Gao, Z., Qi, Y., Qiu, W., Pan, Z., Guo, Q., Li, B., Zhao, S., Guo, X., Qian, M., Chen, Z., Wang, S., Gao, X., Zhang, S., Wang, H., Guo, X., Zhang, P., … Li, G. (2021). Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction. Cell Death & Disease, 12(4), 1–16. https://doi.org/10.1038/s41419-021-03664-1 Cite
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Nitidine Chloride Suppresses Epithelial-Mesenchymal Transition and Stem Cell-Like Properties in Glioblastoma by Regulating JAK2/STAT3 Signaling

Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
[Cancer Medicine]
Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
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S1P Induces Proliferation of Pulmonary Artery Smooth Muscle Cell by Promoting YAP-Induced notch3 Expression and Activation

Investigators demonstrated that sphingosine-1-phosphate (S1P) promoted the activation of STAT3 through sphingosine-1-phosphate receptor 2, and subsequently upregulated the expression of the microRNA miR-135b, which further reduced the expression of E3 ubiquitin ligase β-transduction repeat-containing protein and led to a reduction in YAP ubiquitinated degradation in pulmonary artery smooth muscle cell.
[Journal of Biological Chemistry]
Wang, J., Yan, X., Feng, W., Wang, Q., Shi, W., Chai, L., Zhang, Q., Chen, Y., Liu, J., Qu, Z., Xie, X., & Li, M. (2021). S1P induces proliferation of pulmonary artery smooth muscle cell by promoting YAP-induced Notch3 expression and activation. Journal of Biological Chemistry, 0(0). https://doi.org/10.1016/j.jbc.2021.100599 Cite
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The AXL-PYK2-PKCα Axis as a Nexus of Stemness Circuits in TNBC

Researchers identified a clinically relevant signaling nexus mediated by AXL receptor, PYK2 and PKCα and show its impact on stemness in triple-negative breast cancer.
[Life Science Alliance]
Khera, L., Vinik, Y., Maina, F., & Lev, S. (2021). The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC. Life Science Alliance, 4(6). https://doi.org/10.26508/lsa.202000985 Cite
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation

Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
[Dermatology]
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Interferon Regulatory Factor 1 (IRF-1) Downregulates Checkpoint Kinase 1 (CHK1) through miR-195 to Upregulate Apoptosis and PD-L1 Expression in Hepatocellular Carcinoma (HCC) Cells

IRF-1 induces miR-195 to suppress CHK1 protein expression. Both increased IRF-1 and decreased CHK1 upregulate cellular apoptosis and PD-L1 expression in HCC.
[British Journal of Cancer]
Yan, Y., Zheng, L., Du, Q., Cui, X., Dong, K., Guo, Y., & Geller, D. A. (2021). Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-021-01337-6 Cite
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Nifuroxazide Improves Insulin Secretion and Attenuates High Glucose-Induced Inflammation and Apoptosis in INS-1 Cells

The authors used high concentration glucose-induced INS-1 cells to examine the effects of Nifuroxazide on high glucose-induced cell function by glucose-stimulated insulin secretion.
[European Journal of Pharmacology]
Liu, J.-Y., Zhang, Y.-C., Xie, R.-R., Song, L.-N., Yang, W.-L., Xin, Z., Cao, X., & Yang, J.-K. (2021). Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells. European Journal of Pharmacology, 174042. https://doi.org/10.1016/j.ejphar.2021.174042 Cite
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