Statins Reduce Castration-Induced Bone Marrow Adiposity and Prostate Cancer Progression in Bone

Investigators showed that the cholesterol-lowering drugs statins decreased castration-induced bone marrow adiposity in the tumor microenvironment and reduced prostate cancer progression in bone.
[Oncogene]
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Metabolic Alterations Mediated by STAT3 Promotes Drug Persistence in CML

By exploring the role of STAT3 in altering metabolism, researchers provided insight into identifying potential therapeutic targets for eliminating tyrosine kinase inhibitor-persistent leukemic stem cells.
[Leukemia]
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Inhibition of miR-1298-5p Attenuates Sepsis Lung Injury by Targeting SOCS6

miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.
[Molecular and Cellular Biochemistry]
Ma, J., Xu, L.-Y., Sun, Q.-H., Wan, X.-Y., & BingLi. (2021). Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-021-04170-w Cite
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Synergistic Immunotherapy of Glioblastoma by Dual Targeting of IL-6 and CD40

Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
[Nature Communications]
Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Ali Nabavizadeh, S., Bagley, S. J., Abdullah, K., Brem, S., Zhang, L., Xu, X., Byrne, K. T., Vonderheide, R. H., Gong, Y., & Fan, Y. (2021). Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications, 12(1), 3424. https://doi.org/10.1038/s41467-021-23832-3 Cite
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Surfactant Protein a Modulates the Activities of the JAK/STAT Pathway in Suppressing Th1 and Th17 Polarization in Murine OVA-Induced Allergic Asthma

The authors conducted a study to investigate the effect and mechanisms of action of surfactant protein A in OVA-induced asthmatic mice.
[Laboratory Investigation]
Chen, X., Yue, R., Li, X., Ye, W., Gu, W., & Guo, X. (2021). Surfactant protein A modulates the activities of the JAK/STAT pathway in suppressing Th1 and Th17 polarization in murine OVA-induced allergic asthma. Laboratory Investigation, 1–10. https://doi.org/10.1038/s41374-021-00618-1 Cite
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Targeting the SHP2 Phosphatase Promotes Vascular Damage and Inhibition of Tumor Growth

The authors reported that SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.
[EMBO Molecular Medicine]
Wang, Y., Salvucci, O., Ohnuki, H., Tran, A. D., Ha, T., Feng, J.-X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., & Tosato, G. (2021). Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth. EMBO Molecular Medicine, n/a(n/a), e14089. https://doi.org/10.15252/emmm.202114089 Cite
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Interactions between Cancer Cells and Immune Cells Drive Transitions to Mesenchymal-Like States in Glioblastoma

Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.
[Cancer Cell]
Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Castro, L. N. G., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., … Tirosh, I. (2021). Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.05.002 Cite
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Synergistic Effect of Toosendanin and Regorafenib against Cell Proliferation and Migration by Regulating WWOX Signaling Pathway in Hepatocellular Carcinoma

Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.
[Phytotherapy Research]
Yang, T., Huo, J., Xu, R., & Zhang, Y. (n.d.). Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma. Phytotherapy Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/ptr.7174 Cite
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The Targetable Nanoparticle BAF312@cRGD-CaP-NP Represses Tumor Growth and Angiogenesis by Downregulating the S1PR1/P-STAT3/VEGFA Axis in Triple-Negative Breast Cancer

Researchers prepared shell-core structure nanoparticles which inhibited tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the sphingosine 1 phosphate receptor 1/phosphorylated signal transducer and activator of transcription 3/vascular endothelial growth factor A axis.
[Journal of Nanobiotechnology]
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cGAS Restricts Colon Cancer Development by Protecting Intestinal Barrier Integrity

Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficiency led to intestinal stem cell loss and compromised intestinal barrier integrity upon dextran sodium sulfate-induced acute injury.
[Proceedings of the National Academy of Sciences of the United States of America]
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Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development

Investigators summarize the anti-tumor effects of miR-124. They then discuss the functions of miR-124 with that of its original role in neurons.
[International Journal of Molecular Sciences]
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