Investigators showed that the cholesterol-lowering drugs statins decreased castration-induced bone marrow adiposity in the tumor microenvironment and reduced prostate cancer progression in bone.
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By exploring the role of STAT3 in altering metabolism, researchers provided insight into identifying potential therapeutic targets for eliminating tyrosine kinase inhibitor-persistent leukemic stem cells.
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miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.
[Molecular and Cellular Biochemistry]
Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
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Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Ali Nabavizadeh, S., Bagley, S. J., Abdullah, K., Brem, S., Zhang, L., Xu, X., Byrne, K. T., Vonderheide, R. H., Gong, Y., & Fan, Y. (2021). Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications, 12(1), 3424. https://doi.org/10.1038/s41467-021-23832-3 Cite
The authors conducted a study to investigate the effect and mechanisms of action of surfactant protein A in OVA-induced asthmatic mice.
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The authors reported that SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.
[EMBO Molecular Medicine]
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Wang, Y., Salvucci, O., Ohnuki, H., Tran, A. D., Ha, T., Feng, J.-X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., & Tosato, G. (2021). Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth. EMBO Molecular Medicine, n/a(n/a), e14089. https://doi.org/10.15252/emmm.202114089 Cite
Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.
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Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Castro, L. N. G., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., … Tirosh, I. (2021). Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.05.002 Cite
Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.
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Researchers prepared shell-core structure nanoparticles which inhibited tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the sphingosine 1 phosphate receptor 1/phosphorylated signal transducer and activator of transcription 3/vascular endothelial growth factor A axis.
[Journal of Nanobiotechnology]
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Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficiency led to intestinal stem cell loss and compromised intestinal barrier integrity upon dextran sodium sulfate-induced acute injury.
[Proceedings of the National Academy of Sciences of the United States of America]
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Investigators summarize the anti-tumor effects of miR-124. They then discuss the functions of miR-124 with that of its original role in neurons.
[International Journal of Molecular Sciences]
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