Therapeutic Effects of TM4SF5-Targeting Chimeric and Humanized Monoclonal Antibodies in Hepatocellular and Colon Cancer Models

The authors evaluated the effects of chimeric Ab27 using cancer cells expressing endogenous transmembrane 4 L six family member 5 (TM4SF5) or stably overexpressing TM4SF5 in vivo and in vitro.
[Molecular Therapy-Oncolytics]
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TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes

Researchers stimulated post-confluent human keratinocytes and living skin equivalent with TSLP to investigate the role of nuclear IL-33 in TSLP-induced epidermal barrier defects.
[Journal of Investigative Dermatology]
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The Inhibition of Panc1 Cancer Cells Invasion by hAMSCs Secretome through Suppression of Tyrosine Phosphorylation of SGK223 (at Y411 Site), C-src (at Y416, Y530 Sites), AKT Activity, and JAK1/Stat3 Signaling

Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.
[Medical Oncology]
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The E3 Ubiquitin Ligase SOCS-7 Reverses Immunosuppression via Shc1 Signaling in Hepatocellular Carcinoma

Scientists identified SOCS-7, an inhibitor of cytokine signaling, as a novel regulator of immunosuppression in hepatocellular carcinoma.
[Laboratory Investigation]
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miR-204–Containing Exosomes Ameliorate GVHD-Associated Dry Eye Disease

Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.
[Science Advances]
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STAT3 Induces Breast Cancer Growth via ANGPTL4, MMP13 and STC1 Secretion by Cancer Associated Fibroblasts

Researchers demonstrated that STAT3 was essential for the pro-tumorigenic functions of murine breast cancer cancer associated fibroblasts both in vitro and in vivo, and identified a STAT3 signature significantly enriched for genes encoding for secreted proteins.
[Oncogene]
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Demethylase JMJD2D Induces PD-L1 Expression to Promote Colorectal Cancer Immune Escape by Enhancing IFNGR1-STAT3-IRF1 Signaling

Scientists reported that both PD-L1 and JMJD2D were frequently overexpressed in human colorectal cancer specimens with a significant positive correlation.
[Oncogene]
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Role, Molecular Mechanism and the Potential Target of Breast Cancer Stem Cells in Breast Cancer Development

Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.
[Biomedicine & Pharmacotherapy]
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TMEM158 Promotes the Proliferation and Migration of Glioma Cells via STAT3 Signaling in Glioblastomas

Researchers found that TMEM158 expression in human glioma cells in the tumor core was significantly higher than that in noncancerous cells at the tumor edge using bioinformatics analysis.
[Cancer Gene Therapy]
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Cryptococcus neoformans in Association with Dermatophagoides pteronyssinus Has Pro- (IL-6/STAT3 Overproduction) and Anti-inflammatory (CCL2/ERK1/2 Downregulation) Effects on Human Bronchial Epithelial Cells

The authors evaluated the effects of the association between Cryptococcus neoformans and Dermatophagoides pteronyssinus in the modulation of airway inflammatory responses in an in vitro experimental model using human bronchial epithelial cells.
[Inflammation]
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Ailanthone Suppresses the Activity of Human Colorectal Cancer Cells through the STAT3 Signaling Pathway

The authors investigated the antitumor effects of Ailanthone on HCT116 and SW620 colon cancer cells, and to analyze the underlying molecular mechanisms.
[International Journal of Molecular Medicine]
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