Insertional Activation of STAT3 and LCK by HIV-1 Proviruses in T Cell Lymphomas

Scientists showed that HIV-1 proviruses integrated in the first introns of signal transducer and activator of transcription 3 and lymphocyte-specific protein tyrosine kinase could play an important role in the development of T cell lymphomas.
[Science Advances]
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Inhibition of JAK2/STAT3 Signaling Pathway by Panaxadiol Limits the Progression of Pancreatic Cancer

Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
[Aging-Us]
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Antiproliferative Activity of Aqueous and Polyphenol-Rich Extracts of Larrea divaricata Cav. on a Melanoma Cell Line

The effects of Larrea divaricata, polyphenols and quercetin-3-methyl ether were assessed on B16F10 melanoma cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3.
[Natural Product Research]
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SNAI1-Mediated Transcriptional Regulation of Epithelial-to-Mesenchymal Transition Genes in Breast Cancer Stem Cells

Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.
[Cellular Signalling]
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Norcantharidin Ameliorates the Development of Murine Lupus via Inhibiting the Generation of IL-17 Producing Cells

Researchers investigated whether norcantharidin (NCTD) exerted therapeutic effects in a mouse systemic lupus erythematosu model. Lupus prone female MRL/lpr mice were treated with NCTD for eight weeks.
[Acta Pharmacologica Sinica]
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Knockdown of POLQ Interferes the Development and Progression of Hepatocellular Carcinoma through Regulating Cell Proliferation, Apoptosis and Migration

The authors found that, upon knockdown of DNA Polymerase Theta (POLQ), the proliferation and migration of hepatocellular carcinoma cells decreased and apoptosis percentage increased.
[Cancer Cell International]
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Targeting Tumor-Stromal IL-6/STAT3 Signaling through IL-1 Receptor Inhibition in Pancreatic Cancer

Investigators showed that IL-1α was overexpressed in both murine and human pancreatic ductal adenocarcinomatumors and engaged with its cognate receptor IL-1R1 which was strongly expressed on stromal cells.
[Molecular Cancer Therapeutics]
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Interleukin-11 Signaling Promotes Cellular Reprogramming and Limits Fibrotic Scarring during Tissue Regeneration

Investigators indicated that interleukin-11 signaling in endothelial cells antagonized profibrotic transforming growth factor–β signaling and endothelial-to-mesenchymal transition, limiting scarring and promoting cardiomyocyte repopulation, after injury.
[Science Advances]
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STAT3 Pathway as a Molecular Target for Resveratrol in Breast Cancer Treatment

Resveratrol (RES), a naturally occurring phytoalexin, has demonstrated anti-cancer activity in several disease models. The authors describe the STAT3 cascade signaling pathway and address the therapeutic targeting of STAT3 by RES as a tool to mitigate breast cancer.
[Cancer Cell International]
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Coronavirus Induces Diabetic Macrophage-Mediated Inflammation via SETDB2

Investigators identified that coronavirus induced an increased Mφ-mediated inflammatory response due to a coronavirus-induced decrease in the histone methyltransferase, SETDB2.
[Proceedings of the National Academy of Sciences of the United States of America]
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Puerarin Inhibits the PERK-eIF2α-ATF4-CHOP Pathway through Inactivating JAK2/STAT3 Signal in Pancreatic Beta-Cells

Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explore its underlying mechanism in the mouse insulinoma cell line.
[American Journal of Chinese Medicine]
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