Artificial modulation of BATF3 was conducted to measure the malignant phenotypes of colorectal cancerc cells, while tumor-bearing mice were examined to determine the in vivo effects.
[Cancer Gene Therapy]
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BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis | Cancer Gene Therapy. (n.d.). Retrieved October 15, 2020, from https://www.nature.com/articles/s41417-020-00223-2 Cite
Scientists discuss the possibility of using various approved drugs, or drugs currently in clinical development, to treat COVID-19. They suggest to enhance STAT1 activity and/or inhibit STAT3 functions for COVID-19 treatment.
[Cell Death & Differentiation]
Scientists demonstrated for the first time, that lineage switching to neuroendocrine states was accompanied by key miRNA alterations including downregulation of miR-106a~363 cluster and upregulation of miR-301a and miR-375. They identified novel miRNA neuroendocrine differentiation drivers that can be exploited for neuroendocrine prostate cancer therapeutic targeting.
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Bhagirath, D., Liston, M., Patel, N., Akoto, T., Lui, B., Yang, T. L., To, D. M., Majid, S., Dahiya, R., Tabatabai, Z. L., & Saini, S. (2020). MicroRNA determinants of neuroendocrine differentiation in metastatic castration-resistant prostate cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01493-8 Cite
Scientists report that the key T helper 17 cell differentiation stimulator, STAT33,4, was subjected to reversible S-palmitoylation on cysteine 108. DHHC7 palmitoylated STAT3 and promoted its membrane recruitment and phosphorylation.
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FT282, JHOS2 and OVCAR4 cells were transiently transfected with either single or pooled TIMP-2 siRNAs. The expression of different genes after TIMP-2 knock down or in response to chemotherapy was determined at the mRNA level by quantitative real time PCR and at the protein level by immunofluorescence.
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Escalona, R. M., Bilandzic, M., Western, P., Kadife, E., Kannourakis, G., Findlay, J. K., & Ahmed, N. (2020). TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells. BMC Cancer, 20(1), 960. https://doi.org/10.1186/s12885-020-07274-6 Cite
Using a MLL-AF9 knock-in mouse model, researchers discovered that consumption of a high-fat diet accelerates the risk of developing acute myeloid leukemia.
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Hermetet, F., Mshaik, R., Simonet, J., Callier, P., Delva, L., & Quéré, R. (2020). High-fat diet intensifies MLL-AF9 -induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells. Scientific Reports, 10(1), 16187. https://doi.org/10.1038/s41598-020-73020-4 Cite
Single-cell transcriptome analysis identified brain-derived neurotrophic factor as a STAT3 target gene with newly accessible chromatin in a unique population of regenerating AT2 cells.
[Nature Cell Biology]
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Paris, A. J., Hayer, K. E., Oved, J. H., Avgousti, D. C., Toulmin, S. A., Zepp, J. A., Zacharias, W. J., Katzen, J. B., Basil, M. C., Kremp, M. M., Slamowitz, A. R., Jayachandran, S., Sivakumar, A., Dai, N., Wang, P., Frank, D. B., Eisenlohr, L. C., Cantu, E., Beers, M. F., … Worthen, G. S. (2020). STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nature Cell Biology, 1–14. https://doi.org/10.1038/s41556-020-0569-x Cite
Stimulator of interferon genes promote intestinal epithelial cells REG3γ expression to inhibit enteric infection and intestinal inflammation, thus, maintaining the intestinal homeostasis.
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Yu, Y., Yang, W., Bilotta, A. J., Yu, Y., Zhao, X., Zhou, Z., Yao, S., Xu, J., Zhou, J., Dann, S. M., Li, Y., & Cong, Y. (n.d.). STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001524R Cite
The authors investigated the effects of sodium propionate on the proliferation, apoptosis, autophagy, and antioxidant production of breast cancer cells.
[Acta Pharmacologica Sinica]
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Park, H.-S., Han, J.-H., Park, J. W., Lee, D.-H., Jang, K.-W., Lee, M., Heo, K.-S., & Myung, C.-S. (2020). Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-00522-2 Cite
Investigators found that miR-196b-5p promoted lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS.
[Cell Death & Disease]
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Researchers explored the metastasis associated negative effect of chronic stress.
[Cell Death & Disease]
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Du, P., Zeng, H., Xiao, Y., Zhao, Y., Zheng, B., Deng, Y., Liu, J., Huang, B., Zhang, X., Yang, K., Jiang, Y., & Ma, X. (2020). Chronic stress promotes EMT-mediated metastasis through activation of STAT3 signaling pathway by miR-337-3p in breast cancer. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02981-1 Cite