Inhibitory Effect of MicroRNA-608 on Lung Cancer Cell Proliferation, Migration, and Invasion by Targeting BRD4 through the JAK2/STAT3 Pathway

Investigators determined the fundamental mechanism of microRNA-608 in the development of lung cancer.
[Bosnian Journal of Basic Medical Sciences]
Xu, W., Sun, D., Wang, Y., Zheng, X., Li, Y., Xia, Y., & Teng, Y. (2020). Inhibitory effect of microRNA-608 on lung cancer cell proliferation, migration, and invasion by targeting BRD4 through the JAK2/STAT3 pathway. Bosnian Journal of Basic Medical Sciences, 20(3), 347–356. https://doi.org/10.17305/bjbms.2019.4216 Cite
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

The authors identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
Yang, L., Wang, H., Yang, X., Wu, Q., An, P., Jin, X., Liu, W., Huang, X., Li, Y., Yan, S., Shen, S., Liang, T., Min, J., & Wang, F. (2020). Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms. Signal Transduction and Targeted Therapy, 5(1), 1–9. https://doi.org/10.1038/s41392-020-00253-0 Cite
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The Role of the Oncostatin M/Osm Receptor β Axis in Activating Dermal Microvascular Endothelial Cells in Systemic Sclerosis

Cell culture experiments were performed in human dermal microvascular endothelial cells and included mRNA and protein analysis, and cell migration and proliferation assays. Ex vivo skin organoid culture was used to evaluate the effect of OSM on perivascular fibrosis.
[Arthritis Research & Therapy]
Marden, G., Wan, Q., Wilks, J., Nevin, K., Feeney, M., Wisniacki, N., Trojanowski, M., Bujor, A., Stawski, L., & Trojanowska, M. (2020). The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Research & Therapy, 22(1), 179. https://doi.org/10.1186/s13075-020-02266-0 Cite
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Polydatin Executes Anticancer Effects against Glioblastoma Multiforme by Inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail Signaling Pathway

The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
[Life Sciences]
Chen, Y., Niu, J., Li, L., Li, Z., Jiang, J., Zhu, M., Dong, T., Zhang, J., Shi, C., Xu, P., Lu, Y., Jiang, Y., Liu, P., & Chen, W. (2020). Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway. Life Sciences, 118158. https://doi.org/10.1016/j.lfs.2020.118158 Cite
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Suppressive Myeloid Cells Are Expanded by Biliary Tract Cancer-Derived Cytokines In Vitro and Associate with Aggressive Disease

Activated signaling pathways and cytokine production were evaluated in a panel of human biliary tract cancer (BTC) cell lines. Human peripheral blood mononuclear cells were cultured with BTC supernatants, with and without cytokine neutralising antibodies, and analysed by flow cytometry or immunoblot.
[British Journal of Cancer]
Ware, M. B., Zaidi, M. Y., Yang, J., Turgeon, M. K., Krasinskas, A., Mace, T. A., Keenan, K., Farren, M. R., Ruggieri, A. N., Li, Y., Zhang, C., Chen, Z., Young, G. S., Elnaggar, O., Che, Z., Maithel, S. K., Bekaii-Saab, T., El-Rayes, B., & Lesinski, G. B. (2020). Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease. British Journal of Cancer, 1–10. https://doi.org/10.1038/s41416-020-1018-0 Cite
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Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.
[iScience]
Chamberlain, T. C., Cheung, S. T., Yoon, J. S. J., Ming-Lum, A., Gardill, B. R., Shakibakho, S., Dzananovic, E., Ban, F., Samiea, A., Jawanda, K., Priatel, J., Krystal, G., Ong, C. J., Cherkasov, A., Andersen, R. J., McKenna, S. A., Petegem, F. V., & Mui, A. L.-F. (2020). Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101433 Cite
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CircularRNA-9119 Protects Hepatocellular Carcinoma Cells from Apoptosis by Intercepting miR-26a/JAK1/STAT3 Signaling

Investigators showed that circ9119 could modulate apoptosis, and broadly, cell proliferation by competitively binding miR-26a, which targeted JAK1-STAT3, in hepatocellular carcinoma cell lines.
[Cell Death & Disease]
Yang, L., Xue, H., Sun, Y., Zhang, L., Xue, F., & Ge, R. (2020). CircularRNA-9119 protects hepatocellular carcinoma cells from apoptosis by intercepting miR-26a/JAK1/STAT3 signaling. Cell Death & Disease, 11(7), 1–12. https://doi.org/10.1038/s41419-020-02807-0 Cite
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms | Signal Transduction and Targeted Therapy. (n.d.). Retrieved July 31, 2020, from https://www.nature.com/articles/s41392-020-00253-0 Cite
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Extracellular ATP Promotes Breast Cancer Invasion and Chemoresistance via SOX9 Signaling

Researchers showed that sex-determining region Y-box 9 (SOX9) was up-regulated after adenosine 5′-triphosphate treatment in breast cancer cells. In vitro invasion and migration assays demonstrated that knocking down SOX9 attenuated ATP-driven invasive capability.
[Oncogene]
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IFN-γ Promoted Exosomes from Mesenchymal Stem Cells to Attenuate Colitis via miR-125a and miR-125b

Exosomes were isolated from control and IFN-γ-primed mesenchymal stem cells and were verified by transmission electron microscope and immunofluorescence staining.
[Cell Death & Disease]
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Pyruvate Kinase M2 Activation Protects against the Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Investigators demonstrated that pyruvate kinase M2 stimulated inflammatory and apoptosis signaling pathways in pulmonary artery smooth muscle cells (PASMCs) and promoted PASMC migration and proliferation.
[Cell and Tissue Research]
Zhang, A., Yu, F., Yu, W., Ye, P., Liu, P., Gu, Y., Chen, S., & Zhang, H. (2020). Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03245-2 Cite
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EGF-Mediated Reduced miR-92a-1-5p Controls HTR-8/SVneo Cell Invasion through Activation of MAPK8 and FAS which in turn Increase MMP-2/-9 Expression

The binding of miR-92a-1-5p to MAPK8 and FAS 3′-UTR was confirmed by Luciferase reporter assay and Rescue assay. EGF increased MMP-2 & MMP-9 expression and reduced TIMP1 expression in HTR-8/SVneo cells.
[Scientific Reports]
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