BATF3 Promotes Malignant Phenotype of Colorectal Cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 Axis

Artificial modulation of BATF3 was conducted to measure the malignant phenotypes of colorectal cancerc cells, while tumor-bearing mice were examined to determine the in vivo effects.
[Cancer Gene Therapy]
BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis | Cancer Gene Therapy. (n.d.). Retrieved October 15, 2020, from https://www.nature.com/articles/s41417-020-00223-2 Cite
Abstract
Bookmark

No account yet? Register

0
Share

An Aberrant STAT Pathway Is Central to COVID-19

Scientists discuss the possibility of using various approved drugs, or drugs currently in clinical development, to treat COVID-19. They suggest to enhance STAT1 activity and/or inhibit STAT3 functions for COVID-19 treatment.
[Cell Death & Differentiation]
Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., & Mak, T. W. (2020). An aberrant STAT pathway is central to COVID-19. Cell Death & Differentiation, 1–17. https://doi.org/10.1038/s41418-020-00633-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

MicroRNA Determinants of Neuroendocrine Differentiation in Metastatic Castration-Resistant Prostate Cancer

Scientists demonstrated for the first time, that lineage switching to neuroendocrine states was accompanied by key miRNA alterations including downregulation of miR-106a~363 cluster and upregulation of miR-301a and miR-375. They identified novel miRNA neuroendocrine differentiation drivers that can be exploited for neuroendocrine prostate cancer therapeutic targeting.
[Oncogene]
Bhagirath, D., Liston, M., Patel, N., Akoto, T., Lui, B., Yang, T. L., To, D. M., Majid, S., Dahiya, R., Tabatabai, Z. L., & Saini, S. (2020). MicroRNA determinants of neuroendocrine differentiation in metastatic castration-resistant prostate cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01493-8 Cite
Abstract
Bookmark

No account yet? Register

0
Share

A STAT3 Palmitoylation Cycle Promotes TH17 Differentiation and Colitis

Scientists report that the key T helper 17 cell differentiation stimulator, STAT33,4, was subjected to reversible S-palmitoylation on cysteine 108. DHHC7 palmitoylated STAT3 and promoted its membrane recruitment and phosphorylation.
[Nature]
Zhang, M., Zhou, L., Xu, Y., Yang, M., Xu, Y., Komaniecki, G. P., Kosciuk, T., Chen, X., Lu, X., Zou, X., Linder, M. E., & Lin, H. (2020). A STAT3 palmitoylation cycle promotes T H 17 differentiation and colitis. Nature, 1–6. https://doi.org/10.1038/s41586-020-2799-2 Cite
Abstract
Bookmark

No account yet? Register

0
Share

TIMP-2 Regulates Proliferation, Invasion and STAT3-Mediated Cancer Stem Cell-Dependent Chemoresistance in Ovarian Cancer Cells

FT282, JHOS2 and OVCAR4 cells were transiently transfected with either single or pooled TIMP-2 siRNAs. The expression of different genes after TIMP-2 knock down or in response to chemotherapy was determined at the mRNA level by quantitative real time PCR and at the protein level by immunofluorescence.
[BMC Cancer]
Escalona, R. M., Bilandzic, M., Western, P., Kadife, E., Kannourakis, G., Findlay, J. K., & Ahmed, N. (2020). TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells. BMC Cancer, 20(1), 960. https://doi.org/10.1186/s12885-020-07274-6 Cite
Abstract
Bookmark

No account yet? Register

0
Share

High-Fat Diet Intensifies MLL-AF9-Induced Acute Myeloid Leukemia through Activation of the FLT3 Signaling in Mouse Primitive Hematopoietic Cells

Using a MLL-AF9 knock-in mouse model, researchers discovered that consumption of a high-fat diet accelerates the risk of developing acute myeloid leukemia.
[Scientific Reports]
Hermetet, F., Mshaik, R., Simonet, J., Callier, P., Delva, L., & Quéré, R. (2020). High-fat diet intensifies MLL-AF9 -induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells. Scientific Reports, 10(1), 16187. https://doi.org/10.1038/s41598-020-73020-4 Cite
Full Article
Bookmark

No account yet? Register

0
Share

STAT3–BDNF–TrkB Signaling Promotes Alveolar Epithelial Regeneration after Lung Injury

Single-cell transcriptome analysis identified brain-derived neurotrophic factor as a STAT3 target gene with newly accessible chromatin in a unique population of regenerating AT2 cells.
[Nature Cell Biology]
Paris, A. J., Hayer, K. E., Oved, J. H., Avgousti, D. C., Toulmin, S. A., Zepp, J. A., Zacharias, W. J., Katzen, J. B., Basil, M. C., Kremp, M. M., Slamowitz, A. R., Jayachandran, S., Sivakumar, A., Dai, N., Wang, P., Frank, D. B., Eisenlohr, L. C., Cantu, E., Beers, M. F., … Worthen, G. S. (2020). STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nature Cell Biology, 1–14. https://doi.org/10.1038/s41556-020-0569-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

STING Controls Intestinal Homeostasis through Promoting Antimicrobial Peptide Expression in Epithelial Cells

Stimulator of interferon genes promote intestinal epithelial cells REG3γ expression to inhibit enteric infection and intestinal inflammation, thus, maintaining the intestinal homeostasis.
[FASEB Journal]
Yu, Y., Yang, W., Bilotta, A. J., Yu, Y., Zhao, X., Zhou, Z., Yao, S., Xu, J., Zhou, J., Dann, S. M., Li, Y., & Cong, Y. (n.d.). STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001524R Cite
Full Article
Bookmark

No account yet? Register

0
Share

Sodium Propionate Exerts Anticancer Effect in Mice Bearing Breast Cancer Cell Xenograft by Regulating JAK2/STAT3/ROS/p38 MAPK Signaling

The authors investigated the effects of sodium propionate on the proliferation, apoptosis, autophagy, and antioxidant production of breast cancer cells.
[Acta Pharmacologica Sinica]
Park, H.-S., Han, J.-H., Park, J. W., Lee, D.-H., Jang, K.-W., Lee, M., Heo, K.-S., & Myung, C.-S. (2020). Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-00522-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

miR-196b-5p-Mediated Downregulation of FAS Promotes NSCLC Progression by Activating IL6-STAT3 Signaling

Investigators found that miR-196b-5p promoted lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Chronic Stress Promotes EMT-Mediated Metastasis Through Activation of STAT3 Signaling Pathway by miR-337-3p in Breast Cancer

Researchers explored the metastasis associated negative effect of chronic stress.
[Cell Death & Disease]
Du, P., Zeng, H., Xiao, Y., Zhao, Y., Zheng, B., Deng, Y., Liu, J., Huang, B., Zhang, X., Yang, K., Jiang, Y., & Ma, X. (2020). Chronic stress promotes EMT-mediated metastasis through activation of STAT3 signaling pathway by miR-337-3p in breast cancer. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02981-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share