Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Scientists used single-cell whole-genome transcriptional profiling and protein quantification to investigate the role of OCT4 in establishing pluripotency in the murine embryo.
[Proceedings of the National Academy of Sciences of the United States of America]
6630899 UTI3W37U items 1 apa default asc 1
Stirparo, G. G., Kurowski, A., Yanagida, A., Bates, L. E., Strawbridge, S. E., Hladkou, S., Stuart, H. T., Boroviak, T. E., Silva, J. C. R., & Nichols, J. (2021). OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2008890118 Cite
To directly define the roles of insulin and IGF-1 receptors in the maintenance of pluripotency and differentiation of stem cells, scientists knocked out both the receptors in induced pluripotent stem cells.
6807162 MU7V4JYV items 1 apa default asc 1
Okawa, E. R., Gupta, M. K., Kahraman, S., Goli, P., Sakaguchi, M., Hu, J., Duan, K., Slipp, B., Lennerz, J. K., & Kulkarni, R. N. (2021). Essential roles of insulin and IGF-1 receptors during embryonic lineage development. Molecular Metabolism, 101164. https://doi.org/10.1016/j.molmet.2021.101164 Cite
The authors report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This was achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6, a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration.
6807162 ZBJYL5SC items 1 apa default asc 1
Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice | Nature Communications. (n.d.). Retrieved January 15, 2021, from https://www.nature.com/articles/s41467-020-20112-4 Cite
The oncogenic role of TINCR was examined in vitro and in vivo in breast cancer. The interaction between TINCR, DNMT1, and miR-503-5p methylation was explored.
[Cell Death & Disease]
6807162 4DGJCQWC items 1 apa default asc 1
Wang, Q., Liu, J., You, Z., Yin, Y., Liu, L., Kang, Y., Li, S., Ning, S., Li, H., Gong, Y., Xu, S., & Pang, D. (2021). LncRNA TINCR favors tumorigenesis via STAT3–TINCR–EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03188-0 Cite
Researchers report a new small-molecule inhibitor with potent antitumor bioactivity, which inhibited multiple oncogenic processes in pancreatic cancer.
6807162 DXI7L8NG items 1 apa default asc 1
Researchers inferred that CXCR4 confers resistance to ionizing radiation (IR) in nonsmall cell lung cancer cells. Further, on the basis of colony forming ability, they found that drug-resistant A549/GR cells with improved CXCR4 expression exhibited more resistance to IR than A549 cells evidenced along with a reduction in the formation of γ-H2AX foci after IR.
[Cell Death & Disease]
1254621 AR744882 items 1 apa default asc 1
Scientists investigated whether IL‐10 alleviated lipopolysaccharide‐induced inflammatory response and skin scarring and explored the possible mechanism of scar formation.
[Journal of Cellular and Molecular Medicine]
6807162 AIPVSRIG items 1 apa default asc 1
Shi, J., Shi, S., Xie, W., Zhao, M., Li, Y., Zhang, J., Li, N., Bai, X., Cai, W., Hu, X., Hu, D., Han, J., & Guan, H. (n.d.). IL-10 alleviates lipopolysaccharide-induced skin scarring via IL-10R/STAT3 axis regulating TLR4/NF-κB pathway in dermal fibroblasts. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16250 Cite
Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology]
6630899 BBX64XE6 items 1 apa default asc 1
Rui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., Xu, H., Tian, J., Wang, S., & Lu, L. (2021). Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00587-3 Cite
Scientists report the efficacy of anti-programmed death 1 antibody with the P-GEMOX (pegaspargase, gemcitabine, and oxaliplatin) regimen in advanced natural killer/T cell lymphoma.
[Signal Transduction and Targeted Therapy]
6445218 NIW37BLL items 1 apa default asc 1
Cai, J., Liu, P., Huang, H., Li, Y., Ma, S., Zhou, H., Tian, X., Zhang, Y., Gao, Y., Xia, Y., Zhang, X., Yang, H., Li, L., & Cai, Q. (2020). Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma. Signal Transduction and Targeted Therapy, 5(1), 1–9. https://doi.org/10.1038/s41392-020-00331-3 Cite
Researchers investigated the role of miR-199a-5p in T helper 17 (Th17) differentiation and determined whether extracellular vesicles derived from miR-199a-5p-modified adipose-derived MSCs could relieve immune thrombocytopenia by inhibiting Th17 differentiation.
6630899 UPFT242J items 1 apa default asc 1
Li, J., Xia, Y., Fan, X., Wu, X., Yang, F., Hu, S., & Wang, Z. (2021). Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation. Laboratory Investigation, 1–10. https://doi.org/10.1038/s41374-020-00515-z Cite