Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Suppressive Myeloid Cell Production from Hematopoietic Progenitors In Vitro

To examine the ontogeny and function of MS1 cells, researchers developed a cellular model for inducing CD14+ MS1 monocytes from healthy bone marrow hematopoietic stem and progenitor cells.
[Science Translational Medicine]
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IL-6 Regulates Autophagy and Chemotherapy Resistance by Promoting BECN1 Phosphorylation

The authors demonstrated that IL-6 activated autophagy through the IL-6/JAK2/BECN1 pathway and promoted chemotherapy resistance in colorectal cancer.
[Nature Communications]
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Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine]
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Metformin Inhibition of Mitochondrial ATP and DNA Synthesis Abrogates NLRP3 Inflammasome Activation and Pulmonary Inflammation

Researchers showed that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide- and SARS-CoV-2-induced Acute respiratory distress syndrome.
[Immunity]
Xian, H., Liu, Y., Nilsson, A. R., Gatchalian, R., Crother, T. R., Tourtellotte, W. G., Zhang, Y., Aleman-Muench, G. R., Lewis, G., Chen, W., Kang, S., Luevanos, M., Trudler, D., Lipton, S. A., Soroosh, P., Teijaro, J., Torre, J. C. de la, Arditi, M., Karin, M., & Sanchez-Lopez, E. (2021). Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.05.004 Cite
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Synergistic Immunotherapy of Glioblastoma by Dual Targeting of IL-6 and CD40

Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
[Nature Communications]
Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Ali Nabavizadeh, S., Bagley, S. J., Abdullah, K., Brem, S., Zhang, L., Xu, X., Byrne, K. T., Vonderheide, R. H., Gong, Y., & Fan, Y. (2021). Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications, 12(1), 3424. https://doi.org/10.1038/s41467-021-23832-3 Cite
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In Vitro Expansion of Fetal Liver Hematopoietic Stem Cells

Scientists explored the expansion of fetal liver hematopoietic stem cells under in vitro conditions. They isolated mononuclear cells from fetal liver and hematopoietic stem cells were identified and analyzed by cell surface marker CD34.
[Scientific Reports]
Bhardwaj, R., Kumar, L., Chhabra, D., Mehra, N. K., Sharma, A., Mohanty, S., & Kochupillai, V. (2021). In vitro expansion of fetal liver hematopoietic stem cells. Scientific Reports, 11(1), 11879. https://doi.org/10.1038/s41598-021-91272-6 Cite
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Epithelial PBLD Attenuates Intestinal Inflammatory Response and Improves Intestinal Barrier Function by Inhibiting NF-κB Signaling

Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.
[Cell Death & Disease]
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Oleoylethanolamide Induces Eosinophilic Airway Inflammation in Bronchial Asthma

To investigate the effect of OEA, the expression of proinflammatory cytokines was measured by RT-qPCR and ELISA in airway epithelial (A549) cells.
[Experimental and Molecular Medicine]
Kwon, E.-K., Choi, Y., Yoon, I.-H., Won, H.-K., Sim, S., Lee, H.-R., Kim, H. S., Ye, Y.-M., Shin, Y. S., Park, H.-S., & Ban, G.-Y. (2021). Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-021-00622-x Cite
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Integrated Metabolomic Analysis and Cytokine Profiling Define Clusters of Immuno-Metabolic Correlation in New-Onset Psoriasis

Researchers analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-onset psoriasis and healthy subjects by HR-MAS NMR and Bio-Plex immunoassay.
[Scientific Reports]
Tarentini, E., Odorici, G., Righi, V., Paganelli, A., Giacomelli, L., Mirisola, V., Mucci, A., Benassi, L., D’Aversa, E., Lasagni, C., Kaleci, S., Reali, E., & Magnoni, C. (2021). Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis. Scientific Reports, 11(1), 10472. https://doi.org/10.1038/s41598-021-89925-7 Cite
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The Two Facets of gp130 Signaling in Liver Tumorigenesis

The authors summarize current knowledge on how gp130 signaling and STAT3 in tumor cells and cells of the tumor micro-environment drives hepatic tumorigenesis.
[Seminars in Immunopathology]
Schmidt-Arras, D., Galun, E., & Rose-John, S. (2021). The two facets of gp130 signalling in liver tumorigenesis. Seminars in Immunopathology. https://doi.org/10.1007/s00281-021-00861-0 Cite
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Impact of Rare and Common Genetic Variation in the Interleukin-1 Pathway on Human Cytokine Responses

Scientists performed molecular inversion probe sequencing on 48 IL-1 pathway-related genes in 463 healthy individuals from the Human Functional Genomics Project.
[Genome Medicine]
van Deuren, R. C., Arts, P., Cavalli, G., Jaeger, M., Steehouwer, M., van de Vorst, M., Gilissen, C., Joosten, L. A. B., Dinarello, C. A., Mhlanga, M. M., Kumar, V., Netea, M. G., van de Veerdonk, F. L., & Hoischen, A. (2021). Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses. Genome Medicine, 13(1), 94. https://doi.org/10.1186/s13073-021-00907-w Cite
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