Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation

The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.
[Immunity]
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Genetic Deletion of the Cannabinoid Receptors CB1 and CB2 Enhances Inflammation with Diverging Effects on Skin Wound Healing in Mice

In order to clarify the role of endocannabinoid system receptors in wound healing, excisional wounds were created on wildtype and CB1 and CB2 knockout mice.
[Life Sciences]
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In Vitro Impact Preliminary Assessment of Airborne Particulate from Metalworking and Woodworking Industries

3D airway epithelial tissues allowed to mimic exposure conditions in vitro, generated human-relevant toxicology data, and allowed to elucidate the mode of action of pollutants.
[Scientific Reports]
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Endometrial Mesenchymal Stem/Stromal Cells: The Enigma to Code Messages for Generation of Functionally Active Regulatory T Cells

The effect of MSCs on proliferation of anti-CD3/CD28-stimulated T CD4+ cells and generation of Tregs with or without pre-treatment with mitomycin C, IFN-γ and IL-1β was evaluated by flow cytometry.
[Stem Cell Research & Therapy]
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Conquering the Cytokine Storm in COVID-19-Induced ARDS Using Placenta-Derived Decidua Stromal Cells

Researchers conducted a safety and efficacy study that included ten patients with a median age of 50 years with COVID-19-induced acute respiratory distress syndrome (ARDS).
[Journal of Cellular and Molecular Medicine]
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A Modified Animal Model of Hepatic Regeneration Induced by Hilar Bile Duct Ligation

Scientists aimed to establish a new type of rapid liver hyperplasia model induced mainly by bile acid pathway through hepatoenteral circulation with hilar bile duct ligation. Immunohistochemistry results confirmed the proliferation of hepatocytes in the unligated liver lobe.
[Scientific Reports]
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Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies

Researchers investigated if selective blocking of neuropeptide Y (NPY) receptors, NPY1R or NPY2R, using small molecule non-peptide antagonists (BIBP-3222 for NPY1R and BIIE-0246 for NPY2R) in the colon could attenuate intestinal inflammation by lowering TNF levels.
[Inflammatory Bowel Diseases]
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PLCγ2 Regulates TREM2 Signaling and Integrin-Mediated Adhesion and Migration of Human iPSC-Derived Macrophages

To explore the relationship between PLCγ2 and TREM2 and the role of PLCγ2 in regulating immune cell function, the authors generated human iPSC- derived macrophages from isogenic lines with homozygous PLCG2 knockout.
[Scientific Reports]
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Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.
[Stem Cells and Development]
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Effects of Electrical Stimulation on Human Skin Keratinocyte Growth and the Secretion of Cytokines and Growth Factors

The authors demonstrated that the proliferation of keratinocytes and their secretion of cytokines and growth factors could be activated through appropriate electrical stimulation to benefit skin wound healing.
[Biomedical Materials]
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CXCL12-Abundant Reticular Cells Are the Major Source of IL-6 upon LPS-Stimulation and Thereby Regulate Hematopoiesis

Through a combination of gene expression analysis in prospectively isolated non-hematopoietic bone marrow (BM) cell populations and various mouse models, the authors revealed that BM CXCL12-abundant reticular cells were a major source of systemic and local BM IL-6 levels during emergency hematopoiesis following lipopolysaccharide stimulation.
[Blood Advances]
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