The Effects of Citrus Flavonoids and Their Metabolites on Immune-Mediated Intestinal Barrier Disruption Using an In Vitro Co-Culture Model

Researchers assessed the effect of citrus flavonoids and their intestinal metabolites on immune-mediated barrier disruption in an in vitro co-culture model.
[British Journal of Nutrition]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s

Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.
[International Journal of Biological Macromolecules]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

M-CSF Supports Medullary Erythropoiesis and Erythroid Iron Demand Following Burn Injury through Its Activity on Homeostatic Iron Recycling

The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.
[Scientific Reports]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Cigarette Smoke Augments CSF3 Expression in Neutrophils to Compromise Alveolar-Capillary Barrier Function during Influenza Infection

The authors used a mouse model of concurrent cigarette smoke exposure and H1N1 influenza infection, colony-stimulating factor (CSF)3 supplementation/receptor blockade, and single-cell RNA sequencing to investigate this relationship.
[European Respiratory Journal]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells

Investigators showed that CCL18 did not change the expression of the inflammatory factors, interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, or inducible nitric oxide synthase, but significantly induced expression of the macrophage markers, MRC-1 and ARG-1 M2, in a human microglial clone 3 cell line
[Journal of Interferon and Cytokine Research]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

miR-204–Containing Exosomes Ameliorate GVHD-Associated Dry Eye Disease

Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.
[Science Advances]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

STAT3 Induces Breast Cancer Growth via ANGPTL4, MMP13 and STC1 Secretion by Cancer Associated Fibroblasts

Researchers demonstrated that STAT3 was essential for the pro-tumorigenic functions of murine breast cancer cancer associated fibroblasts both in vitro and in vivo, and identified a STAT3 signature significantly enriched for genes encoding for secreted proteins.
[Oncogene]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

IL-13Rα2 Humanized scFv-Based CAR T Cells Exhibit Therapeutic Activity against Glioblastoma with Increased Expansion and Reduced Cytokine Production

Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.
[Molecular Therapy-Oncolytics]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

The Orphan Receptor GPRC5B Activates Pro-inflammatory Signaling in the Vascular Wall via Fyn and NFκB

In endothelial cells and vascular smooth muscle cells, stimulation with high glucose, TNFα or LPS induced a significant upregulation of endogenous GPRC5B mRNA and protein levels.
[Biochemical and Biophysical Research Communications]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

A20 (TNFAIP3) Alleviates Viral Myocarditis through ADAR1/miR-1a-3p-Dependent Regulation

A20 was underexpressed and miR-1a-3p was overexpressed in the myocardium of VMC mice as well as in Coxsackie virus B3-infected cardiomyocytes.
[BMC Cardiovascular Disorders]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium

Researchers measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies and sera of nonischemic PVB19-positive and PVB19-negative dilated cardiomyopathy patients.
[Advances in Experimental Medicine and Biology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share