Dermal Fibroblasts Have Different Extracellular Matrix Profiles Induced by TGF-β, PDGF and IL-6 in a Model for Skin Fibrosis

Researchers investigated the expression of extracellular matrix by dermal fibroblast mimicking fibrotic skin diseases as systemic sclerosis using clinically validated biomarkers.
[Scientific Reports]
Juhl, P., Bondesen, S., Hawkins, C. L., Karsdal, M. A., Bay-Jensen, A.-C., Davies, M. J., & Siebuhr, A. S. (2020). Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis. Scientific Reports, 10(1), 17300. https://doi.org/10.1038/s41598-020-74179-6 Cite
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6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling

Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
[Molecules]
Liu, R., Choi, H. S., Kim, S.-L., Kim, J.-H., Yun, B.-S., & Lee, D.-S. (2020). 6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling. Molecules, 25(19), 4374. https://doi.org/10.3390/molecules25194374 Cite
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SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer

Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.
[Cancers]
Gwak, J., Jeong, H., Lee, K., Shin, J. Y., Sim, T., Na, J., Kim, J., & Ju, B.-G. (2020). SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer. Cancers, 12(9), 2718. https://doi.org/10.3390/cancers12092718 Cite
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Peptidome Analysis of Umbilical Cord Mesenchymal Stem Cell (hUC-MSC) Conditioned Medium from Preterm and Term Infants

Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
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Secreted Factors from Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells

Investigators designed hydrogel biomaterials as valve ECM mimics enabling the culture of valvular interstitial cells in either their quiescent fibroblast or activated myofibroblast phenotype in response to the local matrix stiffness.
[Arteriosclerosis Thrombosis and Vascular Biology]
Grim Joseph C., Aguado Brian A., Vogt Brandon J., Batan Dilara, Andrichik Cassidy L., Schroeder Megan E., Gonzalez-Rodriguez Andrea, Yavitt F. Max, Weiss Robert M., & Anseth Kristi S. (n.d.). Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 0(0), ATVBAHA.120.315261. https://doi.org/10.1161/ATVBAHA.120.315261 Cite
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Multiplexed Analysis of Neural Cytokine Signaling by a Novel Neural Cell–Cell Interaction Microchip

The authors generated a neural cell-cell interaction microchip as an in vitro platform to simultaneously track an informed panel of cytokines and co-evaluate cell morphology and biomarker expression coupled to a sandwich ELISA platform.
[Lab on a Chip]
Abdullah, M. A. A., Amini, N., Yang, L., Paluh, J. L., & Wang, J. (2020). Multiplexed analysis of neural cytokine signaling by a novel neural cell–cell interaction microchip. Lab on a Chip. https://doi.org/10.1039/D0LC00401D Cite
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Sarcoidosis Exosomes Stimulate Monocytes to Produce Pro-Inflammatory Cytokines and CCL2

The authors found that bronchoalveolar lavage fluid exosomes from sarcoidosis patients, but not from healthy individuals, induced a dose-dependent elevation of intracellular IL-1β in monocytes.
[Scientific Reports]
Wahlund, C. J. E., Gucluler Akpinar, G., Steiner, L., Ibrahim, A., Bandeira, E., Lepzien, R., Lukic, A., Smed-Sörensen, A., Kullberg, S., Eklund, A., Grunewald, J., & Gabrielsson, S. (2020). Sarcoidosis exosomes stimulate monocytes to produce pro-inflammatory cytokines and CCL2. Scientific Reports, 10(1), 15328. https://doi.org/10.1038/s41598-020-72067-7 Cite
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Long Non-Coding RNA SNHG3, Induced by IL-6/STAT3 Transactivation, Promotes Stem Cell-Like Properties of Gastric Cancer Cells by Regulating the miR-3619-5p/ARL2 Axis

Scientists clarified the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer.
[Cellular Oncology]
Sun, B., Han, Y., Cai, H., Huang, H., & Xuan, Y. (2020). Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis. Cellular Oncology. https://doi.org/10.1007/s13402-020-00560-2 Cite
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Ageing and Atherosclerosis: Vascular Intrinsic and Extrinsic Factors and Potential Role of IL-6

Investigators speculate that vascular and myeloid cell ageing synergize, via IL-6 signalling, to accelerate atherosclerosis.
[Nature Reviews Cardiology]
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Palmitic Acid Induces Inflammation in Placental Trophoblasts and Impairs Their Migration toward Smooth Muscle Cells through Plasminogen Activator Inhibitor-1

Investigatiors found that smooth muscle cells (SMCs) and SMC-conditioned media stimulated migration and invasion of an extravillous trophoblasts-like cell line, HTR8/SVneo.
[Molecular Human Reproduction]
Rampersaud, A. M., Dunk, C. E., Lye, S. J., & Renaud, S. J. (n.d.). Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. Molecular Human Reproduction. https://doi.org/10.1093/molehr/gaaa061 Cite
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TRIM21 Is Decreased in Colitis-associated Cancer and Negatively Regulates Epithelial Carcinogenesis

Researchers analyzed Tripartite motif-containing 21 (TRIM21) expression in tumor tissues from patients with colorectal cancer and ulcerative colitis-associated cancer by immunohistochemistry and real-time polymerase chain reaction and established a CAC model in TRIM21−∕− and wild type mice by azoxymethane and dextran sodium sulfate.
[Inflammatory Bowel Diseases]
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