Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
[International Journal of Molecular Sciences]
Mato-Basalo, R., Morente-López, M., Arntz, O. J., van de Loo, F. A. J., Fafián-Labora, J., & Arufe, M. C. (2021). Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells. International Journal of Molecular Sciences, 22(7), 3367. https://doi.org/10.3390/ijms22073367 Cite
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Hypoxic Glioma-Derived Exosomes Promote M2-Like Macrophage Polarization by Enhancing Autophagy Induction

The authors investigated the effects of glioma-derived exosomes on autophagy, the polarization of tumor-associated macrophages, and glioma progression.
[Cell Death & Disease]
Xu, J., Zhang, J., Zhang, Z., Gao, Z., Qi, Y., Qiu, W., Pan, Z., Guo, Q., Li, B., Zhao, S., Guo, X., Qian, M., Chen, Z., Wang, S., Gao, X., Zhang, S., Wang, H., Guo, X., Zhang, P., … Li, G. (2021). Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction. Cell Death & Disease, 12(4), 1–16. https://doi.org/10.1038/s41419-021-03664-1 Cite
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CARD10 Cleavage by MALT1 Restricts Lung Carcinoma Growth In Vivo

Preventing CARD10 cleavage in the lung tumor A549 cell line increased basal levels of IL-6 and extracellular matrix components in vitro.
[Oncogenesis]
Israël, L., Glück, A., Berger, M., Coral, M., Ceci, M., Unterreiner, A., Rubert, J., Bardet, M., Ginster, S., Golding-Ochsenbein, A. M., Martin, K., Hoyler, T., Calzascia, T., Wieczorek, G., Hillenbrand, R., Ferretti, S., Ferrero, E., & Bornancin, F. (2021). CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo. Oncogenesis, 10(4), 1–11. https://doi.org/10.1038/s41389-021-00321-2 Cite
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Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
Ye, H., Pan, J., Gong, E., Cai, X., Xu, C., Li, Y., Zheng, H., & Cao, Z. (2021). Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis. Cancer Biotherapy and Radiopharmaceuticals. https://doi.org/10.1089/cbr.2020.3855 Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

HUVECs and human lung microvascular endothelial cells incubated with human sickle cell plasma had significant increases in pro-inflammatory IL-8, IL-6, and soluble VCAM-1 secretion compared to endothelial cells incubated with normal plasma.
[Frontiers in Immunology]
Zhang, P., Nguyen, J., Abdulla, F., Nelson, A. T., Beckman, J. D., Vercellotti, G. M., & Belcher, J. D. (2021). Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.632709 Cite
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MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation

Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
[Dermatology]
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Chondrogenic and BMP-4 Primings Confer Osteogenesis Potential to Human Cord Blood Mesenchymal Stromal Cells Delivered with Biphasic Calcium Phosphate Ceramics

The authors evaluated the in vitro osteogenic potential of unprimed, osteogenically primed, or chondrogenically primed cord blood MSCs and bone marrow MSCs and their in vivo bone forming capacity following ectopic implantation on biphasic calcium phosphate ceramics in nude mice.
[Scientific Reports]
Brennan, M. Á., Barilani, M., Rusconi, F., de Lima, J., Vidal, L., Lavazza, C., Lazzari, L., Giordano, R., & Layrolle, P. (2021). Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics. Scientific Reports, 11(1), 6751. https://doi.org/10.1038/s41598-021-86147-9 Cite
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Artemisinin Improves Neurocognitive Deficits Associated with Sepsis by Activating the AMPK Axis in Microglia

In BV2 microglial cells treated with LPS, pre-application of artemisinin significantly reduced the production of proinflammatory cytokines and suppressed microglial migration.
[Acta Pharmacologica Sinica]
Lin, S., Wei, J., Hu, J., Bu, J., Zhu, L., Li, Q., Liao, H., Lin, P., Ye, S., Chen, S., & Chen, X. (2021). Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-021-00634-3 Cite
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Identification of Extracellular Matrix Proteins Secreted by Human Dermal Fibroblasts Cultured in 3D Electrospun Scaffolds

Researchers constructed an artificial 3D tumor by culturing human breast cancer JIMT-1 cells and human dermal fibroblasts in a 3D network of electrospun polycaprolactone fibres. They investigated ECM components produced by the cells in the artificial 3D tumor, which is an important step in validating the model.
[Scientific Reports]
Malakpour-Permlid, A., Buzzi, I., Hegardt, C., Johansson, F., & Oredsson, S. (2021). Identification of extracellular matrix proteins secreted by human dermal fibroblasts cultured in 3D electrospun scaffolds. Scientific Reports, 11(1), 6655. https://doi.org/10.1038/s41598-021-85742-0 Cite
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