Weighted Gene Coexpression Network and Experimental Analyses Identify lncRNA SPRR2C as a Regulator of the IL-22-Stimulated HaCaT Cell Phenotype through the miR-330/STAT1/S100A7 Axis

Scientists identified lncRNA SPRR2C (small proline-rich protein 2C) as a hub gene with a critical effect on the pathogenesis of psoriasis and response to treatment using both weighted gene coexpression network analysis and differential expression analysis. SPRR2C expression was significantly upregulated in both psoriatic lesion samples and HaCaT cell lines in response to IL-22 treatment.
[Cell Death & Disease]
Luo, M., Huang, P., Pan, Y., Zhu, Z., Zhou, R., Yang, Z., & Wang, C. (2021). Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis. Cell Death & Disease, 12(1), 1–15. https://doi.org/10.1038/s41419-020-03305-z Cite
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Transneuronal Delivery of Hyper-Interleukin-6 Enables Functional Recovery after Severe Spinal Cord Injury in Mice

The authors report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This was achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6, a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration.
[Nature Communications]
Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice | Nature Communications. (n.d.). Retrieved January 15, 2021, from https://www.nature.com/articles/s41467-020-20112-4 Cite
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Cathepsin C Promotes Breast Cancer Lung Metastasis by Modulating Neutrophil Infiltration and Neutrophil Extracellular Trap Formation

Scientists showed that tumor-secreted protease cathepsin C promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.
[Cancer Cell]
Xiao, Y., Cong, M., Li, J., He, D., Wu, Q., Tian, P., Wang, Y., Yang, S., Liang, C., Liang, Y., Wen, J., Liu, Y., Luo, W., Lv, X., He, Y., Cheng, D., Zhou, T., Zhao, W., Zhang, P., … Hu, G. (2021). Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.12.012 Cite
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Impact of Placental Malaria on Maternal, Placental and Fetal Cord Responses and Its Role in Pregnancy Outcomes in Women from Blue Nile State, Sudan

Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.
[Malaria Journal]
Omer, S., Franco-Jarava, C., Noureldien, A., Omer, M., Abdelrahim, M., Molina, I., & Adam, I. (2021). Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan. Malaria Journal, 20(1), 35. https://doi.org/10.1186/s12936-021-03580-x Cite
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Carbon Dioxide Inhibits UVB-Induced Inflammatory Response by Activating the Proton-Sensing Receptor, GPR65, in Human Keratinocytes

Scientists examined the anti-inflammatory effects of carbon dioxide (CO2) in human keratinocytes and skin. Keratinocytes were cultured under 15% CO2, irradiated with ultraviolet B (UVB), and their inflammatory cytokine production was analyzed.
[Scientific Reports]
Sayama, K., Yuki, K., Sugata, K., Fukagawa, S., Yamamoto, T., Ikeda, S., & Murase, T. (2021). Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. Scientific Reports, 11(1), 379. https://doi.org/10.1038/s41598-020-79519-0 Cite
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Development of Hematopoietic Syndrome Mice Model for Localized Radiation Exposure

Researchers developed a mice model for studying the hematopoietic syndrome in the non-uniform or partial body exposure scenarios using the localized cobalt60 gamma radiation exposure.
[Scientific Reports]
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Octenidine-Based Hydrogel Shows Anti-Inflammatory and Protease-Inhibitory Capacities in Wounded Human Skin

Proteomics analysis of octenidine dihydrochloride-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines and matrix-metalloproteinases when compared to controls.
[Scientific Reports]
Seiser, S., Janker, L., Zila, N., Mildner, M., Rakita, A., Matiasek, J., Bileck, A., Gerner, C., Paulitschke, V., & Elbe-Bürger, A. (2021). Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin. Scientific Reports, 11(1), 32. https://doi.org/10.1038/s41598-020-79378-9 Cite
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Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens

The phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratinocytes and isolate mouse skin specimens, which were exposed to hydrogen peroxide and/or to the extract.
[Antioxidants]
di Giacomo, V., Recinella, L., Chiavaroli, A., Orlando, G., Cataldi, A., Rapino, M., Di Valerio, V., Politi, M., Antolini, M. D., Acquaviva, A., Bacchin, F., Di Mascio, M., Leone, S., Brunetti, L., Menghini, L., Carradori, S., Zengin, G., Ak, G., & Ferrante, C. (2021). Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens. Antioxidants, 10(1), 44. https://doi.org/10.3390/antiox10010044 Cite
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HUCMSCs Transplantation Combined with Ultrashort Wave Therapy Attenuates Neuroinflammation in Spinal Cord Injury through NUR77/ NF-κB Pathway

Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
[Life Sciences]
Wang, S., Jia, Y., Cao, X., Feng, S., Na, L., Dong, H., Gao, J., & Zhang, L. (2020). HUCMSCs transplantation combined with ultrashort wave therapy attenuates neuroinflammation in spinal cord injury through NUR77/ NF-κB pathway. Life Sciences, 118958. https://doi.org/10.1016/j.lfs.2020.118958 Cite
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Olfactory Ecto-Mesenchymal Stem Cell-Derived Exosomes Ameliorate Murine Sjögren’s Syndrome by Modulating the Function of Myeloid-Derived Suppressor Cells

Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology]
Rui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., Xu, H., Tian, J., Wang, S., & Lu, L. (2021). Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00587-3 Cite
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The Persistence of Interleukin-6 Is Regulated by a Blood Buffer System Derived from Dendritic Cells

Scientists found that conventional dendritic cells, defined in mice via expression of the transcription factor Zbtb46, were a major source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling.
[Immunity]
The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells: Immunity. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/immunity/fulltext/S1074-7613(20)30508-2 Cite
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