Scientists identified lncRNA SPRR2C (small proline-rich protein 2C) as a hub gene with a critical effect on the pathogenesis of psoriasis and response to treatment using both weighted gene coexpression network analysis and differential expression analysis. SPRR2C expression was significantly upregulated in both psoriatic lesion samples and HaCaT cell lines in response to IL-22 treatment.
[Cell Death & Disease]
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Luo, M., Huang, P., Pan, Y., Zhu, Z., Zhou, R., Yang, Z., & Wang, C. (2021). Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis. Cell Death & Disease, 12(1), 1–15. https://doi.org/10.1038/s41419-020-03305-z Cite
The authors report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This was achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6, a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration.
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Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice | Nature Communications. (n.d.). Retrieved January 15, 2021, from https://www.nature.com/articles/s41467-020-20112-4 Cite
Scientists showed that tumor-secreted protease cathepsin C promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.
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Xiao, Y., Cong, M., Li, J., He, D., Wu, Q., Tian, P., Wang, Y., Yang, S., Liang, C., Liang, Y., Wen, J., Liu, Y., Luo, W., Lv, X., He, Y., Cheng, D., Zhou, T., Zhao, W., Zhang, P., … Hu, G. (2021). Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.12.012 Cite
Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.
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Omer, S., Franco-Jarava, C., Noureldien, A., Omer, M., Abdelrahim, M., Molina, I., & Adam, I. (2021). Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan. Malaria Journal, 20(1), 35. https://doi.org/10.1186/s12936-021-03580-x Cite
Scientists examined the anti-inflammatory effects of carbon dioxide (CO2) in human keratinocytes and skin. Keratinocytes were cultured under 15% CO2, irradiated with ultraviolet B (UVB), and their inflammatory cytokine production was analyzed.
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Sayama, K., Yuki, K., Sugata, K., Fukagawa, S., Yamamoto, T., Ikeda, S., & Murase, T. (2021). Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. Scientific Reports, 11(1), 379. https://doi.org/10.1038/s41598-020-79519-0 Cite
Researchers developed a mice model for studying the hematopoietic syndrome in the non-uniform or partial body exposure scenarios using the localized cobalt60 gamma radiation exposure.
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Proteomics analysis of octenidine dihydrochloride-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines and matrix-metalloproteinases when compared to controls.
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Seiser, S., Janker, L., Zila, N., Mildner, M., Rakita, A., Matiasek, J., Bileck, A., Gerner, C., Paulitschke, V., & Elbe-Bürger, A. (2021). Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin. Scientific Reports, 11(1), 32. https://doi.org/10.1038/s41598-020-79378-9 Cite
The phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratinocytes and isolate mouse skin specimens, which were exposed to hydrogen peroxide and/or to the extract.
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di Giacomo, V., Recinella, L., Chiavaroli, A., Orlando, G., Cataldi, A., Rapino, M., Di Valerio, V., Politi, M., Antolini, M. D., Acquaviva, A., Bacchin, F., Di Mascio, M., Leone, S., Brunetti, L., Menghini, L., Carradori, S., Zengin, G., Ak, G., & Ferrante, C. (2021). Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens. Antioxidants, 10(1), 44. https://doi.org/10.3390/antiox10010044 Cite
Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
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Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology]
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Rui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., Xu, H., Tian, J., Wang, S., & Lu, L. (2021). Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00587-3 Cite
Scientists found that conventional dendritic cells, defined in mice via expression of the transcription factor Zbtb46, were a major source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling.
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The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells: Immunity. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/immunity/fulltext/S1074-7613(20)30508-2 Cite