PELP1/Src-3-Dependent Regulation of Metabolic Pfkfb Kinases Drives Therapy Resistant Er+ Breast Cancer

Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
[Oncogene]
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Arginine Methyltransferase PRMT5 Methylates and Stabilizes KLF5 via Decreasing Its Phosphorylation and Ubiquitination to Promote Basal-Like Breast Cancer

Protein arginine methyltransferase 5 (PRMT5) promoted breast cancer stem cell maintenance and proliferation, at least partially, by stabilizing krüppel-like factor 5 (KLF5).
[Cell Death & Differentiation]
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Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

The authors discuss various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast cancer stem cells.
[International Journal of Molecular Sciences]
Gote, V., Nookala, A. R., Bolla, P. K., & Pal, D. (2021). Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue. International Journal of Molecular Sciences, 22(9), 4673. https://doi.org/10.3390/ijms22094673 Cite
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Identification of Inhibitory Immune Checkpoints and Relevant Regulatory Pathways in Breast Cancer Stem Cells

Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast cancer stem cells, which were potentially regulated by Wnt, TGF‐β, and Hedgehog signaling.
[Cancer Medicine]
Shi, H., & Yang, Y. (n.d.). Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3902 Cite
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Signaling Pathways Governing Breast Cancer Stem Cells Behavior

Scientists discuss known signaling mechanisms involved in the stimulation or prevention of breast cancer stem cells self-renewal, metastasis, and tumorigenesis.
[Stem Cell Research & Therapy]
Song, K., & Farzaneh, M. (2021). Signaling pathways governing breast cancer stem cells behavior. Stem Cell Research & Therapy, 12(1), 245. https://doi.org/10.1186/s13287-021-02321-w Cite
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Cancer Stem Cell-Targeted Therapeutic Approaches for Overcoming Trastuzumab Resistance in HER2‐Positive Breast Cancer

The authors discuss the role of epithelial‐mesenchymal transition of breast cancer stem cells (BCSCs) in the setting of trastuzumab resistance and approaches of reducing or eradicating BCSCs in HER2positive breast cancer.
[Stem Cells]
Qiu, Y., Yang, L., Liu, H., & Luo, X. (n.d.). Cancer Stem Cell-Targeted Therapeutic Approaches for Overcoming Trastuzumab Resistance in HER2-Positive Breast Cancer. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3381 Cite
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TWIST1-Mediated Transcriptional Activation of PDGFRβ in Breast Cancer Stem Cells Promotes Tumorigenesis and Metastasis

Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast CSCs.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
Yeeravalli, R., Kaushik, K., & Das, A. (2021). TWIST1-mediated transcriptional activation of PDGFRβ in breast cancer stem cells promotes tumorigenesis and metastasis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 166141. https://doi.org/10.1016/j.bbadis.2021.166141 Cite
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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Novel Molecular Regulators of Breast Cancer Stem Cell Plasticity and Heterogeneity

Investigators summarized the novel regulators existed in breast cancer stem cells (BCSCs) and their niches for BCSC heterogeneity which has been discovered in recent years, and discuss their regulation mechanisms and the latest corresponding cancer treatments.
[Seminars in Cancer Biology]
Zhang, R., Tu, J., & Liu, S. (2021). Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2021.03.008 Cite
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Transmembrane and Coiled-Coil Domain Family 3 (TMCC3) Regulates Breast Cancer Stem Cell and AKT Activation

Researchers demonstrated greater expression of TMCC3 in breast cancer stem cells (BCSCs) than non-BCSCs and higher expression of TMCC3 in metastatic lymph nodes and lungs than in primary tumor of breast cancer patient-derived xenograft.
[Oncogene]
Wang, Y.-H., Chan, Y.-T., Hung, T.-H., Hung, J.-T., Kuo, M.-W., Wang, S.-H., Huang, Y., Lin, Y.-J., Chen, S.-C., Yu, J.-C., Wu, J.-C., Yu, J., & Yu, A. L. (2021). Transmembrane and coiled-coil domain family 3 (TMCC3) regulates breast cancer stem cell and AKT activation. Oncogene, 1–14. https://doi.org/10.1038/s41388-021-01729-1 Cite
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Electrospun Nanofiber Scaffolds for the Propagation and Analysis of Breast Cancer Stem Cells In Vitro

The authors developed a 3D culture platform that mimics the metastatic tumor extracellular matrix to effectively increase cancer stem cell (CSC) population in vitro and allow CSC analysis.
[Biomedical Materials]
Prieto, E. I., Mojares, E. B. A., Cortez, J. J. M., & Jr, M. R. V. (2021). Electrospun nanofiber scaffolds for the propagation and analysis of breast cancer stem cells in vitro. Biomedical Materials, 16(3), 035004. https://doi.org/10.1088/1748-605x/abc3dd Cite
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