Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
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Protein arginine methyltransferase 5 (PRMT5) promoted breast cancer stem cell maintenance and proliferation, at least partially, by stabilizing krüppel-like factor 5 (KLF5).
[Cell Death & Differentiation]
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The authors discuss various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast cancer stem cells.
[International Journal of Molecular Sciences]
Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast cancer stem cells, which were potentially regulated by Wnt, TGF‐β, and Hedgehog signaling.
Scientists discuss known signaling mechanisms involved in the stimulation or prevention of breast cancer stem cells self-renewal, metastasis, and tumorigenesis.
[Stem Cell Research & Therapy]
The authors discuss the role of epithelial‐mesenchymal transition of breast cancer stem cells (BCSCs) in the setting of trastuzumab resistance and approaches of reducing or eradicating BCSCs in HER2‐positive breast cancer.
Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast CSCs.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
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The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
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Investigators summarized the novel regulators existed in breast cancer stem cells (BCSCs) and their niches for BCSC heterogeneity which has been discovered in recent years, and discuss their regulation mechanisms and the latest corresponding cancer treatments.
[Seminars in Cancer Biology]
Researchers demonstrated greater expression of TMCC3 in breast cancer stem cells (BCSCs) than non-BCSCs and higher expression of TMCC3 in metastatic lymph nodes and lungs than in primary tumor of breast cancer patient-derived xenograft.
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Wang, Y.-H., Chan, Y.-T., Hung, T.-H., Hung, J.-T., Kuo, M.-W., Wang, S.-H., Huang, Y., Lin, Y.-J., Chen, S.-C., Yu, J.-C., Wu, J.-C., Yu, J., & Yu, A. L. (2021). Transmembrane and coiled-coil domain family 3 (TMCC3) regulates breast cancer stem cell and AKT activation. Oncogene, 1–14. https://doi.org/10.1038/s41388-021-01729-1 Cite
The authors developed a 3D culture platform that mimics the metastatic tumor extracellular matrix to effectively increase cancer stem cell (CSC) population in vitro and allow CSC analysis.
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