Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells-related therapies.
[Journal of Experimental & Clinical Cancer Research]
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Dual Cancer Stem Cell Manipulation to Enhance Phototherapy against Tumor Progression and Metastasis

Investigators engineered a photodynamic nanoplatform to manipulate breast cancer stem cells against tumor progression and metastasis by not only remolding the disequilibrium state but also blocking the epithelial-mesenchymal transition process.
[Journal of Controlled Release]
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HIF-1–Regulated Expression of Calreticulin Promotes Breast Tumorigenesis and Progression through Wnt/β-Catenin Pathway Activation

Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.
[Proceedings of the National Academy of Sciences of the United States of America]
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HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
[Cell Reports]
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lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing a6 Integrin/CD49f Expression in Breast Cancer Stem Cells

To elucidate the underlying mechanisms that drive breast cancer stem cells (BCSCs) tumorigenicity in TNBC, scientists identified the long noncoding RNA BMP/OP-Responsive Gene (BORG) as an enhancer of BCSC phenotypes.
[Molecular Cancer Research]
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Camalexin, an Indole Phytoalexin, Inhibits Cell Proliferation, Migration, and Mammosphere Formation in Breast Cancer Cells via the Aryl Hydrocarbon Receptor

The authors found that camalexin inhibited cell proliferation and migration of breast cancer cell lines. Camalexin also suppressed breast cancer stem cell-derived mammosphere formation.
[Journal of Natural Medicines]
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Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds

Seven CADA compounds (CADA, VGD020, VGD071, TL020, TL023, LAL014, and DJ010) were examined for reduction of cellular sortilin expression and progranulin-induced breast cancer stem cell propagation.
[Journal of the American Chemical Society]
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A Small Molecule Strategy for Targeting Cancer Stem Cells in Hypoxic Microenvironments and Preventing Tumorigenesis

The authors reported a small molecule construct, AzCDF, that allowed the therapeutic targeting of breast cancer stem cells and which was effective in normally refractory hypoxic tumor environments.
[Journal of the American Chemical Society]
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5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2

A natural product 5α-epoxyalantolactone (5α-EAL) was discovered as an anti-breast cancer stem cells lead compound 5α-EAL was found to be able to notably suppress the function of ANXA2 by covalently targeting cysteine 9 of ANXA2.
[Journal of Medicinal Chemistry]
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Simultaneous CK2/TNIK/DYRK1 Inhibition by 108600 Suppresses Triple Negative Breast Cancer Stem Cells and Chemotherapy-Resistant Disease

Scientists described a novel multi-kinase inhibitor, 108600, that suppressed growth, colony and mammosphere forming capacity of breast cancer stem cell-like cells and induced G2M arrest and apoptosis of TNBC cells.
[Nature Communications]
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β-Catenin-CCL2 Feedback Loop Mediates Crosstalk between Cancer Cells and Macrophages That Regulates Breast Cancer Stem Cells

Macrophages co-cultured with breast cancer cells showed a significant increase in CCL2 expression and promoted β-Catenin-induced breast cancer stem cells (BCSCs) properties, whereas depletion of CCL2 by adding neutralizing antibodies suppressed BSCSs properties.
[Oncogene]
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