The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors

The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
[Diagnostics ]
Ko, C. C. H., Chia, W. K., Selvarajah, G. T., Cheah, Y. K., Wong, Y. P., & Tan, G. C. (2020). The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors. Diagnostics, 10(9), 721. https://doi.org/10.3390/diagnostics10090721 Cite
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Combined Inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 Pathways Suppresses Breast Cancer Stem Cells, Tumor Growth, and Metastasis

Investigators showed that novel combinations of JAK2 inhibitors with SMO inhibitors synergistically inhibited in vitro growth of TNBC and HER2-positive trastuzumab-resistant BT474-TtzmR cells.
[Oncogene]
Doheny, D., Sirkisoon, S., Carpenter, R. L., Aguayo, N. R., Regua, A. T., Anguelov, M., Manore, S. G., Arrigo, A., Jalboush, S. A., Wong, G. L., Yu, Y., Wagner, C. J., Chan, M., Ruiz, J., Thomas, A., Strowd, R., Lin, J., & Lo, H.-W. (2020). Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01454-1 Cite
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TV-circRGPD6 Nanoparticle Suppresses Breast Cancer Stem Cells-Mediated Metastasis via miR-26b/YAF2 Axis

Mechanistic analyses determined that hTERT promoter-driven VP16-GAL4-WPRE integrated systemic amplifier delivery composite vector-circular RNA RGPD6 (TV-circRGPD6) suppressed breast cancer stem cell-mediated metastasis via miR-26b/YAF2 axis.
[Molecular Therapy]
Lin, X., Chen, W., Wei, F., & Xie, X. (2020). TV-circRGPD6 nanoparticle suppresses breast cancer stem cells-mediated metastasis via miR-26b/YAF2 axis. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.09.005 Cite
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miRNAs Modulate the Dichotomy of Cisplatin Resistance or Sensitivity in Breast Cancer: An Update of Therapeutic Implications

Authors summarize the general understandings of miRNA-regulated biological processes in breast cancer, particularly focused on the role of miRNA in cisplatin resistance/sensitivity.
[Anti-Cancer Agents in Medicinal Chemistry]
Safi, A., Bastami, M., Delghir, S., Ilkhani, K., & Alivand*, F. S. and M. R. (1969, December 31). miRNAs Modulate the Dichotomy of Cisplatin Resistance or Sensitivity in Breast Cancer: An Update of Therapeutic Implications. Anti-Cancer Agents in Medicinal Chemistry. https://www.eurekaselect.com/185541/article Cite
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Identification and Validation of Stemness-Related lncRNA Prognostic Signature for Breast Cancer

Scientists evaluated the prognostic value of breast cancer stem cells-related lncRNAs and eventually obtained a prognostic risk model consisting of 12 BCSC-related lncRNAs.
[Journal of Translational Medicine]
Identification and validation of stemness-related lncRNA prognostic signature for breast cancer | Journal of Translational Medicine | Full Text. (n.d.). Retrieved September 3, 2020, from https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02497-4 Cite
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The Progress and Clinical Application of Breast Cancer Organoids

Authors review breast cancer organoids, in evolution, source, culture system and clinical applications.
[International Journal of Stem Cells]
Yu, J., & Huang, W. (n.d.). The Progress and Clinical Application of Breast Cancer Organoids. International Journal of Stem Cells. https://doi.org/10.15283/ijsc20082 Cite
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Single-Cell RNA-Sequencing Reveals Distinct Patterns of Cell State Heterogeneity in Mouse Models of Breast Cancer

Researchers revealed that these tumors contained distinct lineage-specific tumor propagating cells and this was reflective of the self-sustaining capabilities of lineage-specific stem/progenitor cells in the mammary epithelial hierarchy.
[elife]
Yeo, S. K., Zhu, X., Okamoto, T., Hao, M., Wang, C., Lu, P., Lu, L. J., & Guan, J.-L. (2020). Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer. ELife, 9, e58810. https://doi.org/10.7554/eLife.58810 Cite
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Immunogenic Cell Death of Breast Cancer Stem Cells by an Endoplasmic Reticulum‐Targeting Copper(II) Complex

Investigators report a copper(II) complex containing a Schiff base ligand and a polypyridyl ligand, 4 capable of inducing immunogenic cell death in breast cancer stem cells.
[Chembiochem]
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AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
[Oncogenesis]
AlAhmari, M. M., Al-Khalaf, H. H., Al-Mohanna, F. H., Ghebeh, H., & Aboussekhra, A. (2020). AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1. Oncogenesis, 9(8), 1–12. https://doi.org/10.1038/s41389-020-00255-1 Cite
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Glycosphingolipid Expression at Breast Cancer Stem Cells after Novel Thieno[2,3-B]Pyridine Anticancer Compound Treatment

Scientists performed studies of viability, type of cell death, cancer stem cell percent and glycosphingolipid expression on CSC and non-CSC after treatment of MDA-MB-231 and MDA-MB-453 triple-negative breast cancer cells with a newly developed thienopyridine anticancer compound.
[Scientific Reports]
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High PKCλ Expression Is Required for ALDH1-Positive Cancer Stem Cell Function and Indicates a Poor Clinical Outcome in Late-Stage Breast Cancer Patients

Functional inhibition of PKCλ through siRNA-mediated knockdown or CRISPR-Cas9-mediated knockout in ALDH1high MDA-MB 157 and MDA-MB 468 basal-like breast cancer cells led to increases in the numbers of trypan blue-positive and active-caspase 3-positive cells, as well as suppression of tumor-sphere formation and cell migration.
[PLoS One]
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