The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
Investigators showed that novel combinations of JAK2 inhibitors with SMO inhibitors synergistically inhibited in vitro growth of TNBC and HER2-positive trastuzumab-resistant BT474-TtzmR cells.
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Doheny, D., Sirkisoon, S., Carpenter, R. L., Aguayo, N. R., Regua, A. T., Anguelov, M., Manore, S. G., Arrigo, A., Jalboush, S. A., Wong, G. L., Yu, Y., Wagner, C. J., Chan, M., Ruiz, J., Thomas, A., Strowd, R., Lin, J., & Lo, H.-W. (2020). Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01454-1 Cite
Mechanistic analyses determined that hTERT promoter-driven VP16-GAL4-WPRE integrated systemic amplifier delivery composite vector-circular RNA RGPD6 (TV-circRGPD6) suppressed breast cancer stem cell-mediated metastasis via miR-26b/YAF2 axis.
Authors summarize the general understandings of miRNA-regulated biological processes in breast cancer, particularly focused on the role of miRNA in cisplatin resistance/sensitivity.
[Anti-Cancer Agents in Medicinal Chemistry]
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Safi, A., Bastami, M., Delghir, S., Ilkhani, K., & Alivand*, F. S. and M. R. (1969, December 31). miRNAs Modulate the Dichotomy of Cisplatin Resistance or Sensitivity in Breast Cancer: An Update of Therapeutic Implications. Anti-Cancer Agents in Medicinal Chemistry. https://www.eurekaselect.com/185541/article Cite
Scientists evaluated the prognostic value of breast cancer stem cells-related lncRNAs and eventually obtained a prognostic risk model consisting of 12 BCSC-related lncRNAs.
[Journal of Translational Medicine]
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Identification and validation of stemness-related lncRNA prognostic signature for breast cancer | Journal of Translational Medicine | Full Text. (n.d.). Retrieved September 3, 2020, from https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02497-4 Cite
Authors review breast cancer organoids, in evolution, source, culture system and clinical applications.
[International Journal of Stem Cells]
Researchers revealed that these tumors contained distinct lineage-specific tumor propagating cells and this was reflective of the self-sustaining capabilities of lineage-specific stem/progenitor cells in the mammary epithelial hierarchy.
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Investigators report a copper(II) complex containing a Schiff base ligand and a polypyridyl ligand, 4 capable of inducing immunogenic cell death in breast cancer stem cells.
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Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
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Scientists performed studies of viability, type of cell death, cancer stem cell percent and glycosphingolipid expression on CSC and non-CSC after treatment of MDA-MB-231 and MDA-MB-453 triple-negative breast cancer cells with a newly developed thienopyridine anticancer compound.
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Functional inhibition of PKCλ through siRNA-mediated knockdown or CRISPR-Cas9-mediated knockout in ALDH1high MDA-MB 157 and MDA-MB 468 basal-like breast cancer cells led to increases in the numbers of trypan blue-positive and active-caspase 3-positive cells, as well as suppression of tumor-sphere formation and cell migration.
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