breast cancer

[Nature] The proteomics studies on liver co-cultures implicated the activated hepatic stellate cells-secreted chemokine CXCL12 in the induction of NK cell quiescence through its cognate receptor CXCR4.

[Molecular Oncology] By probing a number of kinases downstream of integrin-β1, scientists determined that PI3K inhibition with either a tool compounds or a compound in clinical trials robustly sensitizes quiescent breast tumor cells seeded in organotypic bone marrow cultures to chemotherapy.

[npj Breast Cancer] The authors focused on the emerging class of RNAs called long non-coding RNAs or lncRNAs and utilized a MSC-supported triple-negative breast cancer (TNBC) progression model to identify specific family members of functional relevance to TNBC pathogenesis.

[Cell Death Discovery] Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.

[International Journal of Molecular Sciences] Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.

[npj Breast Cancer] Investigators determined the effect of focal adhesion kinase (FAK) inhibition on breast CSC activity alone and in combination with adjuvant therapies.