breast cancer

[American Journal of Pathology] Downregulation of SET-domain containing 5 (SETD5) significantly decreased breast cancer stem-like cells properties and glycolysis in vitro and in vivo.

[Molecular Biology Reports] The expressions and interactions of GDF-15, FOXM1, and stemness (OCT4 and SOX2), and drug resistance (ABCC5) markers were evaluated in breast cancer.

[Experimental Hematology & Oncology] In vitro mammary spheroid formation, flow cytometry assay on CD24−/CD44+ sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells.

[Cell Death & Disease] Scientists found that the low expression of RICH1 in breast cancer was associated with poor prognosis. Depletion of RICH1 promoted the stemness and disrupted the normal epithelial architecture of MCF10A cells.

[Cancer Gene Therapy] Scientists investigated the potential involvement of CLK4 in the metastasis and progression of mesenchymal-like (MES-) TNBC. In the MES-TNBC cell lines, the CLK4 expression was elevated.

[Journal of Clinical Investigation] Investigators used an accurate, single-cell whole genome sequencing approach to first show that telomerized primary mammary epithelial cells heterozygous for a highly penetrant BRCA1 variant displayed a robustly elevated mutation frequency as compared to their isogenic control cells.