breast cancer

[Molecular Therapy Oncolytics] Scientists found that PBX3-activated DLG1-AS1 could promote the proliferation, invasion and migration of TNBC cells by sponging miR-16-5p and elevating JARID2 expression.

[Molecular Therapy Oncolytics] The authors identified that FKBP4/NR3C1 axis was a novel negative regulator of TMEM173 in human breast cancer (BC) cells and demonstrated that FKBP4/NR3C1/TMEM173 signaling pathway could regulate autophagy and proliferation of BC cells as well as dendritic cell abundance through exosome release.

[Theranostics] Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.

[Theranostics] The authors generated mutant mouse strains with heterozygous germline deletion of Gata3 in p18INK4c (p18) deficient backgrounds and developed a Gata3 depleted mammary tumor model system to determine the role of Gata3 loss in controlling cell proliferation and aberrant differentiation in mammary tumor development and progression.

[Frontiers in Immunology] The stemness of OAcGD2+ cells isolated by sorting and the effects of mAb8B6 were assessed by cancer stem cell growth and mammosphere formation in vitro and tumor growth in vivo using patient-derived xenograft models.

[Journal of Experimental & Clinical Cancer Research] The authors elucidated the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provided evidence for the connection between its metabolic actions and suppression of breast cancer.