Loss of Function of GATA3 Induces Basal-Like Mammary Tumors

The authors generated mutant mouse strains with heterozygous germline deletion of Gata3 in p18INK4c (p18) deficient backgrounds and developed a Gata3 depleted mammary tumor model system to determine the role of Gata3 loss in controlling cell proliferation and aberrant differentiation in mammary tumor development and progression.