Overexpressed sFRP3 Exerts an Inhibitory Effect on Hepatocellular Carcinoma via Inactivation of the Wnt/β-Catenin Signaling Pathway

Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
Fang, L., Gao, C., Bai, R.-X., Wang, H.-F., & Du, S.-Y. (2020). Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway. Cancer Gene Therapy, 1–17. https://doi.org/10.1038/s41417-020-0201-z Cite
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TSPAN1 Promotes Autophagy Flux and Mediates Cooperation between WNT-CTNNB1 Signaling and Autophagy via the MIR454-FAM83A-TSPAN1 Axis in Pancreatic Cancer

Scientists demonstrated that TSPAN1 was upregulated in pancreatic cancer and that TSPAN1 depletion decreased pancreatic cancer cell proliferation in vitro and in vivo. TSPAN1 expression was correlated with poor overall survival of pancreatic cancer patients.
[Autophagy]
Zhou, C., Liang, Y., Zhou, L., Yan, Y., Liu, N., Zhang, R., Huang, Y., Wang, M., Tang, Y., Ali, D. W., Wang, Y., Michalak, M., Chen, X.-Z., & Tang, J. (2020). TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1826689 Cite
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DCLK1, a Putative Novel Stem Cell Marker in Human Cholangiocarcinoma

Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
[Hepatology]
Nevi, L., Matteo, S. D., Carpino, G., Zizzari, I., Safarikia, S., Ambrosino, V., Costantini, D., Overi, D., Giancotti, A., Monti, M., Bosco, D., Peppo, V. D., Oddi, A., Rose, A. M. D., Melandro, F., Bragazzi, M. C., Faccioli, J., Massironi, S., Grazi, G. L., … Alvaro, D. (n.d.). DCLK1, a putative novel stem cell marker in human cholangiocarcinoma. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31571 Cite
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miR-184 Targets TP63 to Block Idiopathic Pulmonary Fibrosis by Inhibiting Proliferation and Epithelial–Mesenchymal Transition of Airway Epithelial Cells

Investigators showed abnormal upregulation of tumor protein p63 (TP63) and downregulation of miR-184 in idiopathic pulmonary fibrosis. Transforming growth factor beta 1 stimulation of BEAS-2B and A549 cell lines significantly increased the protein levels of Tp63, alpha-smooth muscle actin, and vimentin, but decreased EpCAM protein levels, and promoted viability of both BEAS-2B and A549 cell lines.
[Laboratory Investigation]
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MicroRNA-3613-5p Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop

Researchers determined that microRNA-3613-5p plays a crucial role in RELA-mediated post-transcriptional regulation of lung adenocarcinoma cell proliferation.
[Molecular Therapy-Nucleic Acids]
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Translational Neuroendocrinology of Human Skin: Concepts and Perspectives

The authors focus on how neurohormones impact human skin physiology and pathology. They highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies.
[Trends in Molecular Medicine]
Ramot, Y., Böhm, M., & Paus, R. (2020). Translational Neuroendocrinology of Human Skin: Concepts and Perspectives. Trends in Molecular Medicine, 0(0). https://doi.org/10.1016/j.molmed.2020.09.002 Cite
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LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
[Oncogene]
Mu, M., Niu, W., Zhang, X., Hu, S., & Niu, C. (2020). LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01466-x Cite
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Stat2 Stability Regulation: An Intersection between Immunity and Carcinogenesis

The authors summarize the role of STAT2 in immune responses and carcinogenesis with respect to the molecular mechanisms of STAT2 stability regulation via the proteasomal degradation pathway.
[Experimental and Molecular Medicine]
Lee, C.-J., An, H.-J., Cho, E. S., Kang, H. C., Lee, J. Y., Lee, H. S., & Cho, Y.-Y. (2020). Stat2 stability regulation: an intersection between immunity and carcinogenesis. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-00506-6 Cite
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Rab13 Regulates sEV Secretion in Mutant KRAS Colorectal Cancer Cells

Researchers showed that Rab13 regulated the secretion of small extracellular vesicles (sEVs) corresponding to both traditional exosomes and a novel subset of vesicles containing both β1-integrin and Rab13. They found that exposure of recipient cells to sEVs from KRAS mutant donor cells increased proliferation and tumorigenesis and that knockdown of Rab13 blocked these effects. Thus, Rab13 serves as both a cargo protein and as a regulator of sEV secretion.
[Scientific Reports]
Hinger, S. A., Abner, J. J., Franklin, J. L., Jeppesen, D. K., Coffey, R. J., & Patton, J. G. (2020). Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells. Scientific Reports, 10(1), 15804. https://doi.org/10.1038/s41598-020-72503-8 Cite
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Inhibition of Protein Tyrosine Phosphatase Receptor Type F Suppresses Wnt Signaling in Colorectal Cancer

Scientists investigated the role of protein tyrosine phosphatase receptor type F (PTPRF), a receptor-type tyrosine phosphatase, in regulating Wnt signaling in colorectal cancer. Knockdown of PTPRF decreased cell proliferation in patient-derived primary colon cancer cells and established colorectal cancer cell lines.
[Oncogene]
Gan, T., Stevens, A. T., Xiong, X., Wen, Y.-A., Farmer, T. N., Li, A. T., Stevens, P. D., Golshani, S., Weiss, H. L., Mark Evers, B., & Gao, T. (2020). Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01472-z Cite
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Discovery of a Novel Dual-Target Inhibitor against RSK1 and MSK2 to Suppress Growth of Human Colon Cancer

The authors identified a novel dual-target inhibitor, APIO-EE-07, that could block both RSK1 and MSK2 kinase activity in a dose-dependent manner. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
[Oncogene]
Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer | Oncogene. (n.d.). Retrieved September 24, 2020, from https://www.nature.com/articles/s41388-020-01467-w Cite
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