Human Endometrium-Derived Stem Cell Improves Cardiac Function after Myocardial Ischemic Injury by Enhancing Angiogenesis and Myocardial Metabolism

Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy]
Fan, X., He, S., Song, H., Yin, W., Zhang, J., Peng, Z., Yang, K., Zhai, X., Zhao, L., Gong, H., Ping, Y., Jiao, X., Zhang, S., Yan, C., Wang, H., Li, R.-K., & Xie, J. (2021). Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Research & Therapy, 12(1), 344. https://doi.org/10.1186/s13287-021-02423-5 Cite
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Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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Targeting Androgen Receptor (AR) with Antiandrogen Enzalutamide Increases Prostate Cancer Cell Invasion Yet Decreases Bladder Cancer Cell Invasion via Differentially Altering the AR/circRNA-ARC1/miR-125b-2-3p or miR-4736/PPARγ/MMP-9 Signals

Researchers found targeting androgens/AR with either the recently developed antiandrogen Enzalutamide or AR-shRNAs led to increased prostate cancer cell invasion, yet decreased bladder cancer cell invasion.
[Cell Death & Differentiation]
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Androgen Receptor (AR) Heterogeneity in Prostate Cancer and Therapy Resistance

The authors summarize the androgen receptor heterogeneity across the prostate cancer (PCa) continuum and discuss its impact on PCa response to treatments.
[Cancer Letters]
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COL11A1 Activates Cancer-Associated Fibroblasts by Modulating TGF-β3 through the NF-κB/IGFBP2 Axis in Ovarian Cancer Cells

Collagen type XI alpha 1 (COL11A1) is overexpressed in cancer-associated fibroblasts (CAFs); therefore this study examined its role during CAF activation in epithelial ovarian cancer.
[Oncogene]
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CDCA2 Protects against Oxidative Stress by Promoting BRCA1–NRF2 Signaling in Hepatocellular Carcinoma

Researchers reported a new factor, CDCA2, in promoting hepatocellular carcinoma (HCC) development. CDCA2 amplification was reported as an independent risk factor for the recurrence and survival of HCC patients, which was positively correlated with elevated level of alpha-fetoprotein, high histological grade, large tumor size, advanced TNM stage, and poor prognosis for HCC patients.
[Oncogene]
Wang, S., Cao, K., Liao, Y., Zhang, W., Zheng, J., Li, X., Huang, M., Zhong, Y., Hu, X., Chen, D., & Wang, Y. (2021). CDCA2 protects against oxidative stress by promoting BRCA1–NRF2 signaling in hepatocellular carcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01855-w Cite
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D-Dopachrome Tautomerase Contributes to Lung Epithelial Repair via Atypical Chemokine Receptor 3-Dependent Akt Signaling

Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.
[Ebiomedicine]
Song, S., Liu, B., Habibie, H., Bor, J. van den, Smit, M. J., Gosens, R., Wu, X., Brandsma, C.-A., Cool, R. H., Haisma, H. J., Poelarends, G. J., & Melgert, B. N. (2021). D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine, 68. https://doi.org/10.1016/j.ebiom.2021.103412 Cite
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Inhibition of miR-1298-5p Attenuates Sepsis Lung Injury by Targeting SOCS6

miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.
[Molecular and Cellular Biochemistry]
Ma, J., Xu, L.-Y., Sun, Q.-H., Wan, X.-Y., & BingLi. (2021). Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-021-04170-w Cite
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MPDZ as a Novel Epigenetic Silenced Tumor Suppressor Inhibits Growth and Progression of Lung Cancer through the Hippo-YAP Pathway

The tumor suppressing effects of MPDZ were determined in vitro and in vivo. The target molecules and signaling pathway that mediated the function of MPDZ were also identified.
[Oncogene]
Liu, W., Huang, Y., Wang, D., Han, F., Chen, H., Chen, J., Jiang, X., Cao, J., & Liu, J. (2021). MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway. Oncogene, 1–18. https://doi.org/10.1038/s41388-021-01857-8 Cite
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miR-802 Regulates Paneth Cell Function and Enterocyte Differentiation in the Mouse Small Intestine

Investigators showed that the intestine-enriched miR-802 was a central regulator of intestinal epithelial cell proliferation, Paneth cell function, and enterocyte differentiation.
[Nature Communications]
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LncRNA Bmp1 Promotes the Healing of Intestinal Mucosal Lesions via the miR-128-3p/PHF6/PI3K/AKT Pathway

The authors investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.
[Cell Death & Disease]
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