SHANK2 Mutations Impair Apoptosis, Proliferation and Neurite Outgrowth during Early Neuronal Differentiation in SH-SY5Y Cells

Using CRISPR/Cas9 genome editing, scientists obtaineded SH-SY5Y cell lines with frameshift mutations on one or both SHANK2 alleles. They investigated the effects of the different SHANK2 mutations on cell morphology, cell proliferation and differentiation potential during early neuronal differentiation.
[Scientific Reports]
Unsicker, C., Cristian, F.-B., von Hahn, M., Eckstein, V., Rappold, G. A., & Berkel, S. (2021). SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells. Scientific Reports, 11(1), 2128. https://doi.org/10.1038/s41598-021-81241-4 Cite
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The Anti-Skin Squamous Cell Carcinoma Cell Activity by the SphK1-Targeting microRNA-6784

The authors identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). They showed that miR-6784 was located at the cytoplasm of A431 skin squamous cell carcinoma cells.
[Aging]
Aging | The anti-skin squamous cell carcinoma cell activity by the SphK1-targeting microRNA-6784 - Full Text. (n.d.). Retrieved January 22, 2021, from https://www.aging-us.com/article/202336/text Cite
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Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

Human keratinocytes cells were used as an experimental model for studies on the effects of platelet-rich plasma on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling.
[International Journal of Molecular Sciences]
Misiura, M., Guszczyn, T., Oscilowska, I., Baszanowska, W., Palka, J., & Miltyk, W. (2021). Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase. International Journal of Molecular Sciences, 22(2), 936. https://doi.org/10.3390/ijms22020936 Cite
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ADO/Hypotaurine: A Novel Metabolic Pathway Contributing to Glioblastoma Development

The authors identified hypotaurine as one of the top-ranked metabolites for differentiating low- and high-grade tumors, and that there was also a strong association between the levels of intratumoral hypotaurine and expression of its biosynthetic enzyme, cysteamine (2-aminoethanethiol) dioxygenase.
[Cell Death Discovery]
Shen, D., Tian, L., Yang, F., Li, J., Li, X., Yao, Y., Lam, E. W.-F., Gao, P., Jin, B., & Wang, R. (2021). ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development. Cell Death Discovery, 7(1), 1–11. https://doi.org/10.1038/s41420-020-00398-5 Cite
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Phosphodiesterase Type-5 Inhibitor Tadalafil Modulates Steroid Hormones Signaling in a Prostate Cancer Cell Line

Researchers demonstrated for the first time that Tadalafil can significantly modulate androgen receptor expression and activity, Cyp19a1 and ERβ expression in prostate cancer cells, suggesting a specific effect of these proteins.
[International Journal of Molecular Sciences]
Bimonte, V. M., Marampon, F., Antonioni, A., Fittipaldi, S., Ferretti, E., Pestell, R. G., Curreli, M., Lenzi, A., Vitale, G., Brunetti, A., Migliaccio, S., & Aversa, A. (2021). Phosphodiesterase Type-5 Inhibitor Tadalafil Modulates Steroid Hormones Signaling in a Prostate Cancer Cell Line. International Journal of Molecular Sciences, 22(2), 754. https://doi.org/10.3390/ijms22020754 Cite
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Long Noncoding RNA SNHG1 Promotes Human Prostate Cancer Progression by Sponging miR-383-5p

Investigators found the level of small nucleolar RNA host gene 1 (SNHG1) was significantly upregulated in prostate cancer tissues and cells. Knockdown of SNHG1 significantly suppressed proliferation, migration and invasion and promoted cell apoptosis in prostate cancer cells.
[Anti-Cancer Drugs]
Huang, G., Guo, X., & Yang, H. (2021). Long noncoding RNA SNHG1 promotes human prostate cancer progression by sponging miR-383-5p. Anti-Cancer Drugs, Publish Ahead of Print. https://doi.org/10.1097/CAD.0000000000000916 Cite
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Down Regulation of U2AF1 Promotes ARV7 Splicing and Prostate Cancer Progression

Scientists investigated the roles of U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) in the resistance to anti-androgen treatment in prostate cancer and its underlying mechanism.
[Biochemical and Biophysical Research Communications]
Cao, H., Wang, D., Gao, R., Chen, L., & Feng, Y. (2021). Down regulation of U2AF1 promotes ARV7 splicing and prostate cancer progression. Biochemical and Biophysical Research Communications, 541, 56–62. https://doi.org/10.1016/j.bbrc.2020.12.111 Cite
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CSN6 Promotes Melanoma Proliferation and Metastasis by Controlling the UBR5-Mediated Ubiquitination and Degradation of CDK9

In melanoma cells, constitutive photomorphogenesis 9 signalosome 6 (CSN6) knockdown remarkably inhibited cell proliferation, tumorigenicity, migration, and invasion, whereas CSN6 recovery rescued the proliferative and metastatic abilities.
[Cell Death & Disease]
Zhang, Y., Hou, J., Shi, S., Du, J., Liu, Y., Huang, P., Li, Q., Liu, L., Hu, H., Ji, Y., Guo, L., Shi, Y., Liu, Y., & Cui, H. (2021). CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. Cell Death & Disease, 12(1), 1–12. https://doi.org/10.1038/s41419-021-03398-0 Cite
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LINC01152 Upregulates MAML2 Expression to Modulate the Progression of Glioblastoma Multiforme via Notch Signaling Pathway

Investigators explored the function and mechanism of LINC01152 in glioblastoma multiforme (GBM). Then qRT-PCR analysis was implemented to search the expression of RNAs in GBM tissues and cells.
[Cell Death & Disease]
Wu, J., Wang, N., Yang, Y., Jiang, G., Mu, Q., Zhan, H., & Li, F. (2021). LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03163-9 Cite
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Comparative Analysis on the Anti-Inflammatory/Immune Effect of Mesenchymal Stem Cell Therapy for the Treatment of Pulmonary Arterial Hypertension

Scientists compared the treatment effects of adipose tissue-, bone marrow-, and umbilical cord blood-derived mesenchymal stem cells in the rat monocrotaline-induced pulmonary hypertension model.
[Scientific Reports]
Oh, S., Jang, A. Y., Chae, S., Choi, S., Moon, J., Kim, M., Spiekerkoetter, E., Zamanian, R. T., Yang, P. C., Hwang, D., Byun, K., & Chung, W.-J. (2021). Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension. Scientific Reports, 11(1), 2012. https://doi.org/10.1038/s41598-021-81244-1 Cite
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Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition

Using a high-throughput approach that combines enteroid monolayers and quantitative imaging, scientists identified conditions that enrich for specific cell types as well as interactions between pathways.
[Developmental Cell]
Sanman, L. E., Chen, I. W., Bieber, J. M., Steri, V., Trentesaux, C., Hann, B., Klein, O. D., Wu, L. F., & Altschuler, S. J. (2021). Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.12.020 Cite
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