The proliferation and fate decisions of basal stem cells are highly regulated by their microenvironment, including the basement membrane and underlying mesenchymal cells. Basal progenitors give rise to differentiated progeny that generate the epidermal barrier. The authors present data that differentiated progeny also regulate the proliferation, differentiation, and migration of basal progenitor cells.
[Cell Stem Cell]
Scientists attempted to investigate the potential role of miR-9-5p in the progression of hepatocellular carcinoma (HCC). Expression of pyruvate dehydrogenase kinase 4 and miR-9-5p was examined in HCC tissues collected from HCC patients and cell lines.
[Cancer Gene Therapy]
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Using two distinct mouse lines, scientists found that increasing contractility of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and prevented their commitment to a hair follicle lineage.
[Cell Stem Cell]
Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
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Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
Scientists generated a novel model of bioartificial human dermis substitute by tissue engineering to treat infected wounds using fibrin-agarose biomaterials functionalized with NLCs loaded with two anti-Pseudomonas antibiotics: sodium colistimethate and amikacin.
[Journal of Nanobiotechnology]
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Chato-Astrain, J., Chato-Astrain, I., Sánchez-Porras, D., García-García, Ó.-D., Bermejo-Casares, F., Vairo, C., Villar-Vidal, M., Gainza, G., Villullas, S., Oruezabal, R.-I., Ponce-Polo, Á., Garzón, I., Carriel, V., Campos, F., & Alaminos, M. (2020). Generation of a novel human dermal substitute functionalized with antibiotic-loaded nanostructured lipid carriers (NLCs) with antimicrobial properties for tissue engineering. Journal of Nanobiotechnology, 18(1), 174. https://doi.org/10.1186/s12951-020-00732-0 Cite
The authors performed single-cell RNA sequencing of human eyelid skin from healthy individuals across different ages and identified 11 canonical cell types, as well as six subpopulations of basal cells.
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Zou, Z., Long, X., Zhao, Q., Zheng, Y., Song, M., Ma, S., Jing, Y., Wang, S., He, Y., Esteban, C. R., Yu, N., Huang, J., Chan, P., Chen, T., Belmonte, J. C. I., Zhang, W., Qu, J., & Liu, G.-H. (2020). A Single-Cell Transcriptomic Atlas of Human Skin Aging. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.11.002 Cite
Researchers showed that activation of mTORC1 signaling was sufficient to induce chronic hyperglucagonemia as a result of α-cell proliferation, cell size and mass expansion. Hyperglucagonemia in a conditional deletion of the mTORC1 inhibitor, TSC2, in α-cells was associated with an increase in glucagon content and enhanced glucagon secretion.
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Investigators demonstrated that miR-199b-5p was significantly downregulated in metastatic prostate cancer (PCa) tissues and cells when compared with the normal prostate tissue, the localized disease, the weakly metastatic and androgen-dependent PCa cell and the normal prostate epithelial cell.
[British Journal of Cancer]
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Scientists investigated the role of glutathione S‑transferase ω 1 (GSTO1) in non‑small cell lung cancer and to determine the potential molecular mechanism. GSTO1 expression levels in A549 cells were knocked down using short hairpin RNA and GSTO1 overexpression in H2122 cells was achieved using cDNA constructs.
[Molecular Medicine Reports]
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Wang, K., Zhang, F.-L., & Jia, W. (2021). Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway. Molecular Medicine Reports, 23(1), 1–1. https://doi.org/10.3892/mmr.2020.11709 Cite
Scientists report the identification of CCN4/Wisp1 as a circulating factor more abundant in pre-weaning than in adult mice. They showed that Wisp1 promoted endogenous and transplanted adult beta cell proliferation in vivo.
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Fernandez-Ruiz, R., García-Alamán, A., Esteban, Y., Mir-Coll, J., Serra-Navarro, B., Fontcuberta-PiSunyer, M., Broca, C., Armanet, M., Wojtusciszyn, A., Kram, V., Young, M. F., Vidal, J., Gomis, R., & Gasa, R. (2020). Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells. Nature Communications, 11(1), 5982. https://doi.org/10.1038/s41467-020-19657-1 Cite
Using Western blotting and qRT-PCR analyses, investigators revealed that in the T47D and BT20 breast cancer cell lines, astaxanthin inhibited expression of pontin and mutp53, as well as the Oct4 and Nanog cancer stem cell stemness genes.