The Glycolytic Process in Endothelial Cells and Its Implications

Since the switches among metabolic processes precede the functional changes and disease developments, some prophylactic and/or therapeutic strategies concerning the role of glycolysis in cardiovascular disease are discussed.
[Acta Pharmacologica Sinica]
Susan, W. S. L., & Shi, Y. (2021). The glycolytic process in endothelial cells and its implications. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-021-00647-y Cite
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CDC2-Like (CLK) Protein Kinase Inhibition as a Novel Targeted Therapeutic Strategy in Prostate Cancer

Scientists measured the effect of the CLK inhibitor, the benzothiazole TG003, on two prostate cancer cell lines. TG003 reduced cell proliferation and increased apoptosis in PC3 and DU145 cells.
[Scientific Reports]
Uzor, S., Porazinski, S. R., Li, L., Clark, B., Ajiro, M., Iida, K., Hagiwara, M., Alqasem, A. A., Perks, C. M., Wilson, I. D., Oltean, S., & Ladomery, M. R. (2021). CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11(1), 7963. https://doi.org/10.1038/s41598-021-86908-6 Cite
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LncRNA-FKBP1C Regulates Muscle Fiber Type Switching By Affecting the Stability of MYH1B

Investigators demonstrated that long non-coding RNA(lncRNA)-FKBP1C could bound with MYH1B and enhance its protein stability, thus affecting proliferation, differentiation of myoblasts and conversion of skeletal muscle fiber types.
[Cell Death Discovery]
Yu, J., Wang, Z., Yang, X., Ma, M., Li, Z., & Nie, Q. (2021). LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00463-7 Cite
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Long-Term Effects of Human Induced Pluripotent Stem Cell-Derived Retinal Cell Transplantation in Pde6b Knockout Rats

Scientists evaluated the long-term effects of human induced pluripotent stem cell-derived retinal pigment epithelial and photoreceptor cell transplantation in Pde6b knockout rats to study retinitis pigmentosa.
[Experimental & Molecular Medicine]
Yang, J. M., Chung, S., Yun, K., Kim, B., So, S., Kang, S., Kang, E., & Lee, J. Y. (2021). Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-021-00588-w Cite
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Global Changes to HepG2 Cell Metabolism in Response to Galactose Treatment

Scientists performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma cells adapted to either glucose or galactose as the aldohexose source.
[American Journal of Physiology-Cell Physiology]
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Mutant KRAS Drives Metabolic Reprogramming and Autophagic Flux in Premalignant Pancreatic Cells

The authors report dynamic metabolic reprogramming in immortalized human non-cancerous pancreatic ductal epithelial cells.
[Cancer Gene Therapy]
Suzuki, T., Kishikawa, T., Sato, T., Takeda, N., Sugiura, Y., Seimiya, T., Sekiba, K., Ohno, M., Iwata, T., Ishibashi, R., Otsuka, M., & Koike, K. (2021). Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-021-00326-4 Cite
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The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
[International Journal of Molecular Sciences]
Magatti, M., Masserdotti, A., Cargnoni, A., Papait, A., Stefani, F. R., Silini, A. R., & Parolini, O. (2021). The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? International Journal of Molecular Sciences, 22(7), 3405. https://doi.org/10.3390/ijms22073405 Cite
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Temporal Multiomic Modeling Reveals a B-Cell Receptor Proliferative Program in Chronic Lymphocytic Leukemia

Using an original ex vivo model of B-cell receptor-induced proliferation of chronic lymphocytic leukemia cells, researchers generated 108 temporal transcriptional and proteomic profiles from one hour up to four days after BCR activation.
[Leukemia]
Schleiss, C., Carapito, R., Fornecker, L.-M., Muller, L., Paul, N., Tahar, O., Pichot, A., Tavian, M., Nicolae, A., Miguet, L., Mauvieux, L., Herbrecht, R., Cianferani, S., Freund, J.-N., Carapito, C., Maumy-Bertrand, M., Bahram, S., Bertrand, F., & Vallat, L. (2021). Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia. Leukemia, 1–12. https://doi.org/10.1038/s41375-021-01221-5 Cite
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Using Wet Electrospun PCL/Gelatin/CNT Yarns to Fabricate Textile-Based Scaffolds for Vascular Tissue Engineering

Researchers report a novel method to fabricate polymer/carbon nanotube (CNT) composite yarns by electrospinning polycaprolactone/gelatin into a bath of CNT dispersion and extracting electrospun fibers out of the bath. In vitro biological test results show that within a limited range of CNT concentrations in the bath, the yarns exhibit good biocompatibility and the ability to guide cell elongation and alignment.
[ACS Biomaterials Science & Engineering]
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Complement Factor I Upregulates Expression of Matrix Metalloproteinase‐13 and ‐2 and Promotes Invasion of Cutaneous Squamous Carcinoma Cells

The authors studied the functional role of complement factor I (CFI) in the progression of cutaneous squamous cell carcinoma (cSCC). CFI was knocked down in cSCC cells and RNA‐seq analysis was performed.
[Experimental Dermatology]
Nezhad, P. R., Riihilä, P., Piipponen, M., Kallajoki, M., Meri, S., Nissinen, L., & Kähäri, V.-M. (n.d.). Complement Factor I upregulates expression of matrix metalloproteinase-13 and -2 and promotes invasion of cutaneous squamous carcinoma cells. Experimental Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/exd.14349 Cite
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Nectin-4 and p95-ErbB2 Cooperatively Regulate Hippo Signaling-Dependent SOX2 Gene Expression, Enhancing Anchorage-Independent T47D Cell Proliferation

The authors found that nectin-4 and p95-ErbB2, but not nectin-4 and either ErbB2 or ErbB2∆Ex16, cooperatively enhanced SOX2 gene expression and cell proliferation in a suspension culture.
[Scientific Reports]
Kedashiro, S., Kameyama, T., Mizutani, K., & Takai, Y. (2021). Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation. Scientific Reports, 11(1), 7344. https://doi.org/10.1038/s41598-021-86437-2 Cite
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