Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
6630899 3JECYCPJ items 1 apa default asc 1
Scientists demonstrated that TSPAN1 was upregulated in pancreatic cancer and that TSPAN1 depletion decreased pancreatic cancer cell proliferation in vitro and in vivo. TSPAN1 expression was correlated with poor overall survival of pancreatic cancer patients.
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Zhou, C., Liang, Y., Zhou, L., Yan, Y., Liu, N., Zhang, R., Huang, Y., Wang, M., Tang, Y., Ali, D. W., Wang, Y., Michalak, M., Chen, X.-Z., & Tang, J. (2020). TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1826689 Cite
Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
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Nevi, L., Matteo, S. D., Carpino, G., Zizzari, I., Safarikia, S., Ambrosino, V., Costantini, D., Overi, D., Giancotti, A., Monti, M., Bosco, D., Peppo, V. D., Oddi, A., Rose, A. M. D., Melandro, F., Bragazzi, M. C., Faccioli, J., Massironi, S., Grazi, G. L., … Alvaro, D. (n.d.). DCLK1, a putative novel stem cell marker in human cholangiocarcinoma. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31571 Cite
Investigators showed abnormal upregulation of tumor protein p63 (TP63) and downregulation of miR-184 in idiopathic pulmonary fibrosis. Transforming growth factor beta 1 stimulation of BEAS-2B and A549 cell lines significantly increased the protein levels of Tp63, alpha-smooth muscle actin, and vimentin, but decreased EpCAM protein levels, and promoted viability of both BEAS-2B and A549 cell lines.
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Researchers determined that microRNA-3613-5p plays a crucial role in RELA-mediated post-transcriptional regulation of lung adenocarcinoma cell proliferation.
[Molecular Therapy-Nucleic Acids]
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The authors focus on how neurohormones impact human skin physiology and pathology. They highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies.
[Trends in Molecular Medicine]
Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
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The authors summarize the role of STAT2 in immune responses and carcinogenesis with respect to the molecular mechanisms of STAT2 stability regulation via the proteasomal degradation pathway.
[Experimental and Molecular Medicine]
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Researchers showed that Rab13 regulated the secretion of small extracellular vesicles (sEVs) corresponding to both traditional exosomes and a novel subset of vesicles containing both β1-integrin and Rab13. They found that exposure of recipient cells to sEVs from KRAS mutant donor cells increased proliferation and tumorigenesis and that knockdown of Rab13 blocked these effects. Thus, Rab13 serves as both a cargo protein and as a regulator of sEV secretion.
Scientists investigated the role of protein tyrosine phosphatase receptor type F (PTPRF), a receptor-type tyrosine phosphatase, in regulating Wnt signaling in colorectal cancer. Knockdown of PTPRF decreased cell proliferation in patient-derived primary colon cancer cells and established colorectal cancer cell lines.
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Gan, T., Stevens, A. T., Xiong, X., Wen, Y.-A., Farmer, T. N., Li, A. T., Stevens, P. D., Golshani, S., Weiss, H. L., Mark Evers, B., & Gao, T. (2020). Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01472-z Cite
The authors identified a novel dual-target inhibitor, APIO-EE-07, that could block both RSK1 and MSK2 kinase activity in a dose-dependent manner. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
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Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer | Oncogene. (n.d.). Retrieved September 24, 2020, from https://www.nature.com/articles/s41388-020-01467-w Cite