Scientists developed a lactate‐dependent cell proliferation assay and found that dynamin‐related protein (DRP1), which was highly expressed in KRAS‐mutant non‐small cell lung cancer (NSCLC), was required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.
Investigators determined the fundamental mechanism of microRNA-608 in the development of lung cancer.
[Bosnian Journal of Basic Medical Sciences]
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Xu, W., Sun, D., Wang, Y., Zheng, X., Li, Y., Xia, Y., & Teng, Y. (2020). Inhibitory effect of microRNA-608 on lung cancer cell proliferation, migration, and invasion by targeting BRD4 through the JAK2/STAT3 pathway. Bosnian Journal of Basic Medical Sciences, 20(3), 347–356. https://doi.org/10.17305/bjbms.2019.4216 Cite
Researchers integrated a computational proteochemometric systems network pharmacology platform, DrugGenEx‐Net, with primary, continuous cultures of conditionally reprogrammed normal and prostate cancer (PCa) cells derived from treatment‐naive patients with primary PCa.
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Naeem, A., Dakshanamurthy, S., Walthieu, H., Parasido, E., Avantaggiati, M., Tricoli, L., Kumar, D., Lee, R. J., Feldman, A., Noon, M. S., Byers, S., Rodriguez, O., & Albanese, C. (n.d.). Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient-derived primary prostate cells. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24050 Cite
Researchers observed the expression of selenoprotein P in livers from patients with hepatocellular carcinoma (HCC) and explored its effect on HCC cells.
Brain organoids derived from iPSCs of patients are a powerful avenue to investigate the pathophysiological processes. Scientists generated iPSC-derived cerebral organoids from monozygotic twins discordant for psychosis.
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Sawada, T., Chater, T. E., Sasagawa, Y., Yoshimura, M., Fujimori-Tonou, N., Tanaka, K., Benjamin, K. J. M., Paquola, A. C. M., Erwin, J. A., Goda, Y., Nikaido, I., & Kato, T. (2020). Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-020-0844-z Cite
Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
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ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
MIR503HG negatively regulated its target miR-107. MiR-107 overexpression reversed the anti-tumor effects of MIR503HG overexpression on colon cancer cells. Par4 was a target of miR-107, which was positively regulated by MIR503HG. The promoting effects of MIR503HG silencing on colon cancer cells were eliminated by Par4 overexpression.
[Experimental Cell Research]
The authors defined the differential responses to trametinib in subpopulations of a clinically-relevant in vitro model of TNBC, and identified both adaptive and acquired elements that contribute to the emergence of drug resistance mediated by increased expression of CXCR7 and amplification of KRAS.
[Molecular Cancer Research]
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Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer | Molecular Cancer Research. (n.d.). Retrieved August 6, 2020, from https://mcr.aacrjournals.org/content/early/2020/08/04/1541-7786.MCR-19-1011 Cite
Investigators integrated data derived from ChIRP-Seq, ChIP-Seq as well as RNA-Seq in a comprehensive analysis and selected a group of bona fide direct transcriptional targets of EPR. Among them, they identified a subset of EPR targets whose expression was controlled by TGF-β with one of them—Arrdc3—being able to modulate Epithelial to Mesenchymal Transition.
[Nucleic Acids Research]
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Comprehensive multi-omics analysis uncovers a group of TGF-β-regulated genes among lncRNA EPR direct transcriptional targets | Nucleic Acids Research | Oxford Academic. (n.d.). Retrieved August 6, 2020, from https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa628/5881275 Cite
Scientists investigated mammary epithelial cell phenotypes and metabolic profiles on animal breast extracellular matrix-derived tissue matrix gel, Col I, and Matrigel. Atomic force microscopy, fluorescence microscopy, acini formation assay, differentiation experiments, spatial migration/invasion assays, proliferation assay, and nuclear magnetic resonance spectroscopy were used to examine biological phenotypes and metabolic changes.
[Breast Cancer Research]
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Distinct phenotypes of cancer cells on tissue matrix gel | Breast Cancer Research | Full Text. (n.d.). Retrieved August 6, 2020, from https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01321-7 Cite
Cell culture experiments were performed in human dermal microvascular endothelial cells and included mRNA and protein analysis, and cell migration and proliferation assays. Ex vivo skin organoid culture was used to evaluate the effect of OSM on perivascular fibrosis.
[Arthritis Research & Therapy]
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Marden, G., Wan, Q., Wilks, J., Nevin, K., Feeney, M., Wisniacki, N., Trojanowski, M., Bujor, A., Stawski, L., & Trojanowska, M. (2020). The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Research & Therapy, 22(1), 179. https://doi.org/10.1186/s13075-020-02266-0 Cite
In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
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