Suppression of Breast Cancer-Associated Bone Loss with Osteoblast Proteomes via Hsp90ab1/Moesin-Mediated Inhibition of TGFβ/FN1/CD44 Signaling

Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.