The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
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Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.
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Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.
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Mullegama, S. V., Klein, S. D., Williams, S. R., Innis, J. W., Probst, F. J., Haldeman-Englert, C., Martinez-Agosto, J. A., Yang, Y., Tian, Y., Elsea, S. H., & Ezashi, T. (2021). Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes. Scientific Reports, 11(1), 11295. https://doi.org/10.1038/s41598-021-90798-z Cite
Scholar Rock, a clinical-stage biopharmaceutical company, announced that the US FDA has granted Fast Track designation for apitegromab, a selective inhibitor of myostatin activation, for the treatment of patients with Spinal Muscular Atrophy.
[Scholar Rock (Business Wire, Inc.)]
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Scientists exposed healthy bone marrow-derived CD34+ hematopoietic stem and progenitor cells (HSPC) to cell-free supernatants derived from acute myeloid leukemia (AML) cell lines to examine proliferation, cell cycling, colony formation, and differentiation of healthy CD34+ HSPC.
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Investigators demonstrated that platelets were recruited into the lung together with neutrophils during the onset of inflammation and alongside Treg cells during the resolution phase.
[Journal of Experimental Medicine]
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Rossaint, J., Thomas, K., Mersmann, S., Skupski, J., Margraf, A., Tekath, T., Jouvene, C. C., Dalli, J., Hidalgo, A., Meuth, S. G., Soehnlein, O., & Zarbock, A. (2021). Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. Journal of Experimental Medicine, 218(e20201353). https://doi.org/10.1084/jem.20201353 Cite
The authors showed that Nur77 enhanced TGFβ/Smad3-induced ID1 mRNA expression through hindering Smurf2-mediated Smad3 mono-ubiquitylation, resulting in ID1 upregulation.
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Using three different murine transgenic models, scientists provide counterintuitive evidence that the Alzheimer’s disease progression required B cells.
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Kim, K., Wang, X., Ragonnaud, E., Bodogai, M., Illouz, T., DeLuca, M., McDevitt, R. A., Gusev, F., Okun, E., Rogaev, E., & Biragyn, A. (2021). Therapeutic B-cell depletion reverses progression of Alzheimer’s disease. Nature Communications, 12(1), 2185. https://doi.org/10.1038/s41467-021-22479-4 Cite
Researchers found that endothelial SIRT3 regulated metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.
The effects of fetuin-A were assessed during in vitro maturation of porcine neonatal islet cell clusters and in adult human islets. Expression alterations were examined via microarray, RNA sequencing and reverse transcription quantitative real-time PCR, proteins were analyzed by western blotting and immunostaining, and insulin secretion was quantified in static incubations.
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The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells | SpringerLink. (n.d.). Retrieved March 30, 2021, from https://link.springer.com/article/10.1007%2Fs00125-021-05435-1 Cite
In vitro colon organoid culture was utilized to assess junction-related gene expression by qPCR and trans-epithelial resistance. In silico analyses of human inflammatory bowel disease and colon cancer databases were performed.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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Marincola Smith, P., Choksi, Y. A., Markham, N. O., Hanna, D. N., Zi, J., Weaver, C. J., Hamaamen, J. A., Lewis, K. B., Yang, J., Liu, Q., Kaji, I., Means, A. L., & Beauchamp, R. D. (2021). Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00053.2021 Cite