Suppression of Breast Cancer-Associated Bone Loss with Osteoblast Proteomes via Hsp90ab1/Moesin-Mediated Inhibition of TGFβ/FN1/CD44 Signaling

Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.
[Theranostics]
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Transforming Growth Factor-β in Myocardial Disease

The authors summarize the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.
[Nature Reviews Cardiology]
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Transforming Growth Factor-β in Myocardial Disease

The author summarizes the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discussing challenges and opportunities for therapeutic translation.
[Nature Review Cardiology]
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HDAC2 Facilitates Pancreatic Cancer Metastasis

Using genetically defined models, researchers showed that HDAC2 was a cellular fitness factor that controls cell cycle in vitro and metastasis in vivo, particularly in undifferentiated, mesenchymal pancreatic ductal adenocarcinoma cells.
[Cancer Research]
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Protective Effects of Galangin against H2O2/UVB-Induced Dermal Fibroblast Collagen Degradation via Hsa-microRNA-4535-Mediated TGFβ/Smad Signaling

The authors investigated the mechanism underlying the protective effects of galangin against H2O2/UVB-induced damage using in vitro and in vivo models of photodamage.
[Aging]
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Distinct Roles of KLF4 in Mesenchymal Cell Subtypes during Lung Fibrogenesis

Researchers indicated that KLF4 played opposing roles in platelet-derived growth factor receptor-β+ cells and α-smooth muscle actin+ cells and highlighted the importance of further studies of interactions between distinct mesenchymal cell types.
[Nature Communications]
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SMAD4 Mutations Do Not Preclude Epithelial–Mesenchymal Transition in Colorectal Cancer

It was widely assumed that SMAD4-mutant (SMAD4mut) cancer cells were unable to undergo epithelial-mesenchymal transition (EMT). Researchers scrutinized this notion and probed for potential SMAD4-independent EMT execution using SMAD4mut colorectal cancer cell lines.
[Oncogene]
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Cell Autonomous TGFβ Signaling Is Essential for Stem/Progenitor Cell Recruitment into Degenerative Tendons

Through immunohistochemistry and inducible gene deletion, researchers found that the recruitment of stem/progenitor cells into degenerative mutant tendons originated from a Sox9-expressing lineage and their recruitment was dependent on cell autonomous TGFβ signaling.
[Stem Cell Reports]
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Inner Nuclear Membrane Protein TMEM201 Promotes Breast Cancer Metastasis by Positive Regulating TGFβ Signaling

The authors showed that TMEM201, as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo.
[Oncogene]
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Modulation of Cell Signaling and Sulfation in Cardiovascular Development and Disease

Immunocytochemical analysis confirmed SULF1/SULF2 expression in endothelial cell lining of blood vessels and in developing cardiomyocytes, but not in the adult cardiomyocytes despite persisting at reduced levels in the adult endothelial cells.
[Scientific Reports]
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Isoform Specific Anti-TGFβ Therapy Enhances Antitumor Efficacy in Mouse Models of Cancer

Using B16 mouse melanoma and CT26 colon carcinoma as models of stroma-poor tumors, researchers demonstrated that myeloid/dendritic cells were the main sources of TGFβ1 and TGFβ3.
[Communications Biology]
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