Researchers explored the role of a collagen‐chondroitin sulfate scaffold functionalized with a pro‐angiogenic gene stromal‐derived factor‐1 alpha (SDF‐1α) – an SDF‐1α gene‐activated scaffold on the functional regulation of human Schwann cells.
[Biotechnology and Bioengineering]
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Researchers investigated the expression of extracellular matrix by dermal fibroblast mimicking fibrotic skin diseases as systemic sclerosis using clinically validated biomarkers.
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Juhl, P., Bondesen, S., Hawkins, C. L., Karsdal, M. A., Bay-Jensen, A.-C., Davies, M. J., & Siebuhr, A. S. (2020). Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis. Scientific Reports, 10(1), 17300. https://doi.org/10.1038/s41598-020-74179-6 Cite
Scientists transplanted either neonatal microglia or adult microglia treated with peptidase inhibitors into spinal cord lesions of adult mice, and found that both types of microglia significantly improved healing and axon regrowth.
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Li, Y., He, X., Kawaguchi, R., Zhang, Y., Wang, Q., Monavarfeshani, A., Yang, Z., Chen, B., Shi, Z., Meng, H., Zhou, S., Zhu, J., Jacobi, A., Swarup, V., Popovich, P. G., Geschwind, D. H., & He, Z. (2020). Microglia-organized scar-free spinal cord repair in neonatal mice. Nature, 1–6. https://doi.org/10.1038/s41586-020-2795-6 Cite
Researchers showed that L19 accumulated in the tumor microenvironment of two orthotopic immunocompetent mouse glioma models.
[Science Translational Medicine]
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This review outlines fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronectin, and concludes by discussing potential future directions to modulate fibronectin function in development and wound healing.
[Advanced Drug Delivery Reviews]
FUJIFILM Irvine Scientific, Inc. has announced that it has become the exclusive, worldwide distributor of cellnest®, a recombinant peptide attachment substrate that provides optimal adhesion and proliferation of stem cells in chemically defined, animal component-free conditions. Attachment substrates mimic the ECM and allow for the adhesion, expansion, and potential differentiation of stem cells.
[FUJIFILM Irvine Scientific, Inc.]
Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes and the extracellular matrx, and the size and physical property of 3D organoids were compared between groups that had been treated with EP2 agonists and PGF2α.
In the absence of exogenous transforming growth factor-beta2 (TGFβ2), compared with control matrices , glucocorticoid-induced cell-derived matrices triggered non-Smad TGFβ2 signaling in human trabecular meshwork cells, correlated with overexpression/activity of structural ECM genes, matricellular genes, crosslinking genes/enzymes, and ECM turnover genes/enzymes.
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Scientists dissected the structural modifications in the tumor microenvironment due to the stromal expression of ADAM9 during melanoma progression.
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Investigators demonstrated that breast cancer-derived extracellular vesicles activated liver sinusoidal endothelial cells in the liver-chip, inducing endothelial to mesenchymal transition and destruction of vessel barriers.
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Kim, J., Lee, C., Kim, I., Ro, J., Kim, J., Min, Y., Park, J., Sunkara, V., Park, Y.-S., Michael, I., Kim, Y.-A., Lee, H. J., & Cho, Y.-K. (2020). Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles. ACS Nano. https://doi.org/10.1021/acsnano.0c04778 Cite
To investigate the effect of ECM stiffness on hepatocyte migration and function, scientists designed an easy fabricated polyvinyl alcohol hydrogel in which stiffness could be controlled by changing the concentration of glutaraldehyde.