Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1α/SLC7A11 Pathway

Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation]
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Materials-Driven Fibronectin Assembly on Nanoscale Topography Enhances Mesenchymal Stem Cell Adhesion, Protecting Cells from Bacterial Virulence Factors and Preventing Biofilm Formation

The authors used a poly ethyl acrylate polymer coating on titanium nanowires to spontaneously organize fibronectin and to deliver bone morphogenetic protein 2 to enhance MSC adhesion and osteospecific signaling.
[Biomaterials]
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Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway

The role of the CCL5 and IL4 in kidney fibrosis was studied by administration of the CCL5 receptor antagonist maraviroc or by injections of an anti-IL4 neutralizing antibody.
[Hypertension]
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Netrin-Like Domain of sFRP4, a Wnt Antagonist Inhibits Stemness, Metastatic and Invasive Properties by Specifically Blocking MMP-2 in Cancer Stem Cells from Human Glioma Cell Line U87MG

Researchers explored the efficacy of the domains of secreted frizzled-related protein 4 (sFRP4) in inhibiting the key hallmarks of glioblastoma such as invasion, metastasis, and stemness.
[Experimental Cell Research]
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Cromolyn Platform Suppresses Fibrosis and Inflammation, Promotes Microglial Phagocytosis and Neurite Outgrowth

Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.
[Scientific Reports]
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High-Impact FN1 Mutation Decreases Chondrogenic Potential and Affects Cartilage Deposition via Decreased Binding to Collagen Type II

Researchers aimed to identify the causal pathogenic mutation in an early-onset osteoarthritis family, followed by functional studies in human iPSCs in an in vitro organoid cartilage model.
[Science Advances]
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Adhesive-Ligand-Independent Cell-Shaping Controlled by the Lateral Deformability of a Condensed Polymer Matrix

The authors used PNIPAAm-grafted substrates as a typical hydrophobic condensed polymer surface to investigate the effects of the lateral mobility of an adhesive ligand in the setting of lateral deformability of hydrophobic condensed polymer layers.
[Polymer Journal]
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miRNA-200c-3p Targets Talin-1 to Regulate Integrin-Mediated Cell Adhesion

Overexpression of miR-200c-3p resulted in a remarkable decrease in the expression of TLN1, which was associated with the suppression of integrin-mediated cell adhesion to fibronectin.
[Scientific Reports]
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Mechanics-Driven Nuclear Localization of YAP Can Be Reversed by N-Cadherin Ligation in Mesenchymal Stem Cells

Researchers developed a material and culture system for modifying and measuring the degree to which cells retained cumulative effects of mechanosensing.
[Nature Communications]
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Establishment of Appropriate Glaucoma Models Using Dexamethasone or TGFβ2 Treated 3D Cultured Human Trabecular Meshwork (HTM) Cells

To establish appropriate ex vivo models for a glaucomatous trabecular meshwork, 2D and 3D cultures of HTM were prepared in the presence of 250 nM dexamethasone or 5 ng/mL TGFβ2, and characterized by various analyses.
[Scientific Reports]
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Integrin α5β1 Nano-Presentation Regulates Collective Keratinocyte Migration Independent of Substrate Rigidity

The authors used a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels to show that keratinocyte sheets regulated their migration ability at an optimal integrin α5β1 nanospacing.
[eLife]
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