Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
[Clinical Cancer Research]
Carter, J. M., Polley, M.-Y. C., Leon-Ferre, R. A., Sinnwell, J., Thompson, K. J., Wang, X., Ma, Y., Zahrieh, D., Kachergus, J. M., Solanki, M., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Thompson, E. A., & Goetz, M. P. (2021). Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0343 Cite
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Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.
[Scientific Reports]
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The Arachidonic Acid Metabolite 11,12-Epoxyeicosatrienoic Acid Alleviates Pulmonary Fibrosis

Liquid chromatography with tandem mass spectrometry was used to analyze epoxyeicosatrienoic acids (EETs) in the lung tissues of patients with idiopathic pulmonary fibrosis and controls, and the function of 11,12-EET was evaluated in in vitro and in vivo in pulmonary fibrosis models.
[Environmental & Molecular Medicine]
Kim, H. S., Moon, S.-J., Lee, S. E., Hwang, G. W., Yoo, H. J., & Song, J. W. (2021). The arachidonic acid metabolite 11,12-epoxyeicosatrienoic acid alleviates pulmonary fibrosis. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-021-00618-7 Cite
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Cereblon Contributes to the Development of Pulmonary Fibrosis via Inactivation of Adenosine Monophosphate-Activated Protein Kinase α1

Scientists evaluated the role of cereblon in bleomycin (BLM)-induced pulmonary fibrosis in mice and in transforming growth factor-beta 1 (TGF-β1)-induced differentiation of human lung fibroblasts.
[Experimental & Molecular Medicine]
Kang, H. J., Lee, K. J., Woo, J., Kim, J., Kim, Y. K., Lee, C.-H., Yoo, C.-G., & Lee, K.-H. (2021). Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1. Experimental & Molecular Medicine, 1–9. https://doi.org/10.1038/s12276-021-00619-6 Cite
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FKRP-Dependent Glycosylation of Fibronectin Regulates Muscle Pathology in Muscular Dystrophy

The role of human fibronectin impairment in muscle cell pathology was investigated in patient-derived fukutin-related protein (FKRP)-deficient primary myoblast cells.
[Nature Communications]
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Integrin α2β1 Regulates Collagen I Tethering to Modulate Hyperresponsiveness in Reactive Airway Disease Models

Researchers showed that another member of the integrin superfamily, integrin α2β1, was present in airway smooth muscle and capable of regulating force transmission via cellular tethering to the matrix protein collagen I, and to a lesser degree, laminin-111.
[Journal of Clinical Investigation]
Liu, S., Ngo, U., Tang, X.-Z., Ren, X., Qiu, W., Huang, X., DeGrado, W., Allen, C. D. C., Jo, H., Sheppard, D., & Sundaram, A. B. (2021). Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI138140 Cite
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The TLR-2/TonEBP Signaling Pathway Regulates 29-kDa Fibronectin Fragment-Dependent Expression of Matrix Metalloproteinases

Investigators examined whether tonicity-responsive enhancer-binding protein (TonEBP) was involved in 29-kDa fibronectin fragments-induced expression of MMPs. The expression of TonEBP was significantly higher in human osteoarthritis compared with normal cartilage samples.
[Scientific Reports]
Hwang, H. S., Lee, M. H., & Kim, H. A. (2021). The TLR-2/TonEBP signaling pathway regulates 29-kDa fibronectin fragment-dependent expression of matrix metalloproteinases. Scientific Reports, 11(1), 8891. https://doi.org/10.1038/s41598-021-87813-8 Cite
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Fibrotic Extracellular Matrix Induces Release of Extracellular Vesicles with Pro-Fibrotic miRNA from Fibrocytes

The extracellular vesicles of fibrocytes derived from fibrotic lungs significantly upregulated the expression of col1a1 of fibroblasts. Culturing on rigid plates or fibrotic decellularised lung scaffolds increased miR-21-5 p expression compared with soft plates or normal lung scaffolds.
[Thorax]
Sato, S., Chong, S. G., Upagupta, C., Yanagihara, T., Saito, T., Shimbori, C., Bellaye, P.-S., Nishioka, Y., & Kolb, M. R. (2021). Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes. Thorax. https://doi.org/10.1136/thoraxjnl-2020-215962 Cite
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Defining Optimal Enzyme and Matrix Combination for Replating of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes at Different Levels of Maturity

The authors revealed the selection criteria of the dissociation approach and coating matrix for replating iPSC-cardiomyocytes based on the maturity and the requirements of further applications.
[Experimental Cell Research]
Koc, A., Goktas, S. S., Caglar, T. A., & Cagavi, E. (2021). Defining Optimal Enzyme and Matrix Combination for Replating of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes at Different Levels of Maturity. Experimental Cell Research, 112599. https://doi.org/10.1016/j.yexcr.2021.112599 Cite
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Silk Films with Nanotopography and Extracellular Proteins Enhance Corneal Epithelial Wound Healing

Silk films with either flat or nanotopography patterned parallel ridge widths of 2000, 1000, 800 nm surfaces were combined with extracellular matrix which included collagen type I, fibronectin, laminin, and Poly-D-Lysine to accelerate corneal wound healing.
[Scientific Reports]
Luo, Y., Kang, K. B., Sartaj, R., Sun, M. G., Zhou, Q., Guaiquil, V. H., & Rosenblatt, M. I. (2021). Silk films with nanotopography and extracellular proteins enhance corneal epithelial wound healing. Scientific Reports, 11(1), 8168. https://doi.org/10.1038/s41598-021-87658-1 Cite
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Rosiglitazone Attenuates High Glucose-Induced Proliferation, Inflammation, Oxidative Stress and Extracellular Matrix Accumulation in Mouse Mesangial Cells through the Gm26917/miR-185-5p Pathway

Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
[Endocrine Journal]
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite
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