iPSC-Derived Progenitor Stromal Cells Provide New Insights into Aberrant Musculoskeletal Development and Resistance to Cancer in Down Syndrome

To gain new insights into aberrant Down Syndrome (DS) development during early stages of mesoderm formation and its possible connection to lower solid tumor prevalence, the authors developed the first model of two types of DS iPSC-derived stromal cells.
[Scientific Reports]
Galat, Y., Perepitchka, M., Elcheva, I., Iannaccone, S., Iannaccone, P. M., & Galat, V. (2020). iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. Scientific Reports, 10(1), 13252. https://doi.org/10.1038/s41598-020-69418-9 Cite
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Relating Polymeric Microparticle Formulation to Prevalence or Distribution of Fibronectin and Poly-d-Lysine to Support Mesenchymal Stem Cell Growth

Using a colocalization analysis approach on ToF-SIMS images of protein-coated microparticles, the authors showed that the use of propyleneglycol over PVA as well as the substitution of poly (lactic-co-glycolic acid) by the triblock copolymer resulted in enhanced protein adsorption.
[Biointerphases]
Ugur, D., Sottile, V., Montero-Menei, C. N., Boury, F., & Zelzer, M. (2020). Relating polymeric microparticle formulation to prevalence or distribution of fibronectin and poly-d-lysine to support mesenchymal stem cell growth. Biointerphases, 15(4), 041008. https://doi.org/10.1116/6.0000226 Cite
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LINC00941 Promotes CRC Metastasis through Preventing SMAD4 Protein Degradation and Activating the TGF-β/SMAD2/3 Signaling Pathway

LINC00941 was found to activate EMT by directly binding the SMAD4 protein MH2 domain and competing with β-TrCP to prevent SMAD4 protein degradation, thus activating the TGF-β/SMAD2/3 signaling pathway.
[Cell Death & Differentiation]
Abstract

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USP10 Targeted Self-Deliverable siRNA to Prevent Scarring in the Cornea

Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids]
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