To gain new insights into aberrant Down Syndrome (DS) development during early stages of mesoderm formation and its possible connection to lower solid tumor prevalence, the authors developed the first model of two types of DS iPSC-derived stromal cells.
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Galat, Y., Perepitchka, M., Elcheva, I., Iannaccone, S., Iannaccone, P. M., & Galat, V. (2020). iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. Scientific Reports, 10(1), 13252. https://doi.org/10.1038/s41598-020-69418-9 Cite
Using a colocalization analysis approach on ToF-SIMS images of protein-coated microparticles, the authors showed that the use of propyleneglycol over PVA as well as the substitution of poly (lactic-co-glycolic acid) by the triblock copolymer resulted in enhanced protein adsorption.
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LINC00941 was found to activate EMT by directly binding the SMAD4 protein MH2 domain and competing with β-TrCP to prevent SMAD4 protein degradation, thus activating the TGF-β/SMAD2/3 signaling pathway.
[Cell Death & Differentiation]
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Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids]
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