breast cancer

[Journal of Controlled Release] Scientists discuss the application of chitosan as an anticancer drug carrier such as tamoxifen, doxorubicin, paclitaxel, docetaxel, etc. and also, its role as a theranostics moieties.

[Cancer Research] Researchers described a mouse embryonic stem cell-based system to quantitatively determine the functional impact of 50 missense variants of uncertain significance in human checkpoint kinase 2 (CHEK2) .

[HiberCell, Inc.] HiberCell announced a clinical trial collaboration with Merck. This metastatic breast cancer clinical trial evaluates KEYTRUDA®, Merck’s anti-PD-1 therapy, in combination with HiberCell’s odetiglucan, a Dectin-1, pattern recognition receptor agonist.

[Laboratory Investigation] Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B-cell lymphoma.

[Journal of Medicinal Chemistry] AL-GDa62 preferentially induced apoptosis in CDH1–/– cells, and Cdh1–/– mammary and gastric organoids were significantly more sensitive to AL-GDa62 at low micromolar concentrations.

[AstraZeneca] New results from the DESTINY-Breast03 Phase III trial showed that Enhertu demonstrated a higher progression-free survival and objective response rate in pre-specified patient subgroups compared to trastuzumab emtansine in patients with HER2-positive unresectable and/or metastatic breast cancer.