breast cancer

[Cell Death & Disease] The authors used a murine model of orthotopic breast cancer to study the tumor-intrinsic role of cyclin-dependent kinase 8 (CDK8) in TNBC and linked CDK8 to programmed death-ligand 1 expression.

[Cell Death & Disease] Scientists applied unpredictable stress stimuli to breast tumor-bearing mice and established a xenograft model of breast cancer that suffered mental stress. This was followed by behavioral tests, tumor growth tracking, immune analysis, miRNA screening, and tumor cell proliferation analysis.

[npj Breast Cancer] Investigators thoroughly characterized the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and in vitro, and assessed if there was overlap between a dormant and a senescent phenotype.

[Scientific Reports] Researchers identified differentially expressed genes via a comparison between luminal A breast cancer subtypes and normal mammary ductal cells from healthy donors.

[Nature Communications] The authors found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.

[Nature Communications] Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Researchers found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.