Triple-Negative Breast Cancer Cells Rely on Kinase-Independent Functions of CDK8 to Evade NK-Cell-Mediated Tumor Surveillance

The authors used a murine model of orthotopic breast cancer to study the tumor-intrinsic role of cyclin-dependent kinase 8 (CDK8) in TNBC and linked CDK8 to programmed death-ligand 1 expression.