The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
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Examining human specimens from free myocutaneous flap transfer demonstrated increased myostatin signaling and tissue damage in terms of apoptotic activity, cell death, tissue edema, and lipid peroxidation.
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Researchers found that the number of β7+ cells decreased significantly in tumor tissue compared with adjacent normal tissue. β7 expression decreased in tumor-derived compared to normal tissue-derived CD8+ T cells.
[Cancer Immunology Research]
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Zhang, Y., Xie, R., Zhang, H., Zheng, Y., Lin, C., Yang, L., Huang, M., Li, M., Song, F., Lu, L., Yang, M., Liu, Y., Wei, Q., Li, J., & Chen, J. (2021). Integrin β7 inhibits colorectal cancer pathogenesis via maintaining anti-tumor immunity. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0879 Cite
Scientists exploited cytokine-induced killer cells’ expression of FcγRIIIa in combination with clinical-grade monoclonal antibodies to redirect their lytic activity in an antigen-specific manner, and reported the efficacy of this combined approach against TNBC.
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Researchers performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease severity, from outpatients with mild disease to fatal cases.
[Journal of Experimental Medicine]
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Wilk, A. J., Lee, M. J., Wei, B., Parks, B., Pi, R., Martínez-Colón, G. J., Ranganath, T., Zhao, N. Q., Taylor, S., Becker, W., Stanford COVID-19 Biobank, Jimenez-Morales, D., Blomkalns, A. L., O’Hara, R., Ashley, E. A., Nadeau, K. C., Yang, S., Holmes, S., Rabinovitch, M., … Blish, C. A. (2021). Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19. Journal of Experimental Medicine, 218(8). https://doi.org/10.1084/jem.20210582 Cite
Shoreline Biosciences, Inc. and BeiGene, Ltd. announced a worldwide collaboration to develop and commercialize a portfolio of natural killer (NK)-based cell therapeutics with Shoreline’s iPSC NK cell technology and BeiGene’s research and clinical development capabilities for different malignancies.
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Scientists performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer patients and found that epigenetic downregulation of B2M was common.
The authors review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies.
[Nature Reviews Immunology]
ONK Therapeutics Ltd announced that it has been awarded an Innovation Partnership Programme grant by Enterprise Ireland to fund collaborative research at Trinity College Dublin, Ireland, led by Dr. David Finlay to optimize the metabolism and engineering of NK cells for improved cancer therapies.
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The authors critically discuss current knowledge regarding predictive biomarkers for checkpoint inhibitor-based immunotherapy, highlight the missing/unclear links and emphasise the importance of characterising each neoplasm and its microenvironment in order to better guide the course of treatment.
[British Journal of Cancer]
Scientists examined 81 lung cancer patients under immune checkpoint blockade (ICB) treatment and found that patients with MET amplification were resistant to ICB and had a poor progress-free survival.
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Zhang, Y., Yang, Q., Zeng, X., Wang, M., Dong, S., Yang, B., Tu, X., Wei, T., Xie, W., Zhang, C., Guo, Q., Kloeber, J. A., Cao, Y., Guo, G., Zhou, Q., Zhao, F., Huang, J., Liu, L., Zhang, K., … Lou, Z. (2021). MET amplification attenuates lung tumor response to immunotherapy by inhibiting STING. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1500 Cite