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Natural Killer Cells

CHMP2A Regulates Tumor Sensitivity to Natural Killer Cell-Mediated Cytotoxicity

[Nature Communications] Scientists used a “two cell type” whole genome CRISPR-Cas9 screening system to discover key regulators of tumor sensitivity and resistance to natural killer cell-mediated cytotoxicity in human glioblastoma stem cells.

Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) Mediate Protection against Influenza a Viral Infection

[Human Vaccines & Immunotherapeutics] Scientists investigated the effects of CYNK-001, human placental hematopoietic stem cell derived NK cells that exhibited strong cytolytic activity against a range of malignant cells and expressed high levels of activating receptors, against influenza A virus infections.

CCR7 Expression in CD19 Chimeric Antigen Receptor-Engineered Natural Killer Cells Improves Migration toward CCL19-Expressing Lymphoma Cells and Increases Tumor Control in Mice with Human...

[Cytotherapy] Since Natural Killer (NK)-92 cells do not spontaneously express CCR7, clinical-grade activated NK cells were transfected with a non-viral vector containing the CCR7 receptor, an anti-CD19 CAR and a high-affinity CD16 Fc receptor.

Artiva Biotherapeutics Announces Agreement with Merck to Evaluate Combinations of NK Cells with Tri-Specific NK-Cell Engagers

[Artiva Biotherapeutics, Inc.] rtiva Biotherapeutics, Inc., an oncology company whose mission is to deliver highly effective, off-the-shelf, allogeneic natural killer cell therapies to treat cancer, announced that it has entered into an agreement with Merck, known as MSD outside the United States and Canada.

Injectable Adhesive Hemostatic Gel with Tumor Acidity Neutralizer and Neutrophil Extracellular Traps Lyase for Enhancing Adoptive NK Cell Therapy Prevents Post-Resection Recurrence of Hepatocellular...

[Biomaterials] A dual pH-responsive hydrogel with tumor acidity neutralizer and neutrophil extracellular traps lyase was developed and used in combination with natural killer cell infusion for preventing post-resection hepatocellular carcinom recurrence.

SNAP25 Is a Potential Prognostic Biomarker for Prostate Cancer

[Cancer Cell International] The authors indicated a relationship between synaptosome associated protein 25 (SNAP25) expression and prostate cancer, demonstrating that SNAP25 was a potential prognostic biomarker due to its vital role in immune infiltration.