Tag Archives: Natural Killer Cells

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Characterizing Cellular Heterogeneity in Fibrotic Hypersensitivity Pneumonitis by Single-Cell Transcriptional Analysis

Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.

[Cell Death Discovery]

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Isolation and Culture of Decidual Natural Killer Cells from Term Placenta and Complete Hydatidiform Mole

A novel protocol was developed to isolate and culture decidual natural killer cells cells from fresh, term placentas and complete hydatidiform moles.

[Journal of Reproductive Immunology]

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industry & policy

Celularity Receives Fast Track Designation from US FDA for Its NK Cell Therapy CYNK-101 in Development for the First-Line Treatment of Advanced HER2/Neu Positive Gastric and Gastroesophageal Junction Cancers

Celularity Inc. announced the US FDA has granted Fast Track Designation for its genetically modified cryopreserved human placental hematopoietic stem cell-derived natural killer (NK) cell therapy, CYNK-101, which is being developed in combination with standard chemotherapy, trastuzumab and pembrolizumab in patients in first-line locally advanced unresectable or metastatic HER2/neu positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.

[Celularity, Inc.]

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Press Release

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Exploiting Natural Killer Cell Engagers to Control Pediatric B Cell Precursor Acute Lymphoblastic Leukemia

Investigators tested the in vitro effect of different NK cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and target either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.

[Cancer Immunology Research]

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Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity

Scientists showed that polymorphonuclear-myeloid-derived suppressor cells were present in high numbers in the polymorphonuclear of patients with primary or metastatic lung tumor.

[Frontiers in Immunology]

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Review

NK Cells in the Brain: Implications for Brain Tumor Development and Therapy

Natural killer (NK) cells lend themselves to off-the-shelf applications owing to their favorable safety profile and retained efficacy in an allogeneic setting.

[Trends in Molecular Medicine]

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Single‐Cell Immune Mapping of Melanoma Sentinel Lymph Nodes Reveals an Actionable Immunotolerant Microenvironment

Researchers used mass cytometry by time-of-flight, flow cytometry, and T cell receptor immunosequencing to conduct simultaneous single-cell analyses of immune cells in the sentinel lymph nodes of melanoma patients.

[Clinical Cancer Research]

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Functional Genomics Analysis Identifies T and NK Cell Activation as a Driver of Epigenetic Clock Progression

Four clocks resulted in similar predictions of individual chronological age, and their constituting CpGs were correlated in DNA methylation level and were enriched for similar histone modifications and chromatin states.

[Genome Biology]

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PDGF-D−PDGFRβ Signaling Enhances IL-15–Mediated Human Natural Killer Cell Survival

Scientists reported an additional but previously unknown role of PDGF-D, whereby it mediated interleukin-15–induced human NK cell survival but not effector functions via its binding to PDGFRβ but independent of its binding to NKp44.

[Proceedings of the National Academy of Sciences of the United States of America]

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industry & policy

Fate Therapeutics Announces FDA Clearance for FT536, a First-in-Class MICA/B-targeted CAR NK Cell Product Candidate for the Treatment of Solid Tumors

Fate Therapeutics, Inc. announced that the US FDA has cleared the company’s Investigational New Drug application for FT536, an off-the-shelf, multiplexed-engineered, iPSC-derived, chimeric antigen receptor NK cell product candidate.

[Fate Therapeutics, Inc.]

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Press Release