Gates Biomanufacturing Facility Announces Strategic Manufacturing Partnership with Cell Therapy Pioneer, Nkarta

The Gates Biomanufacturing Facility signed a continued strategic agreement with Nkarta to manufacture clinical supply of therapeutic Natural Killer cells. As part of this collaboration, GBF will continue to manufacture NKX101, an immunotherapy currently in a Phase I clinical trial for patients with relapsed/refractory acute myeloid leukemia or higher-risk myelodysplastic syndromes.
[Gates Biomanufacturing Facility]
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Targeting of the Tumor Immune Microenvironment by Metformin

The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.
[Journal of Cell Communication and Signaling]
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The Legacy of Maternal SARS-CoV-2 Infection on the Immunology of the Neonate

Scientists characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal immune system.
[Nature Immunology]
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Fermented Food Tempeh Induces Interleukin 12 and Enhances Macrophage Phagocytosis

Researchers investigated the IL-12 inducibility of fermented foods using the specific antibody. Fermented soybean foods such as Tempeh and Natto are attracting attention in terms of nutrition, functionality, and food problems.
[Journal of Food Biochemistry]
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CD127+ CD94+ Innate Lymphoid Cells Expressing Granulysin and Perforin Are Expanded in Patients with Crohn’s Disease

The authors analyzed CD127+ innate lymphoid cells (ILCs) and natural killer cells in intestinal lamina propria from healthy donors and Crohn’s disease patients and identified two populations of CD127+CD94+ ILCs, designated population A and B, that could be distinguished on the expression of CD117, CD18 and cytotoxic molecules.
[Nature Communications]
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CD47-Targeted Cancer Immunogene Therapy: Secreted SIRPα-FC Fusion Protein Eradicates Tumors by Macrophage and NK Cell Activation

Researchers developed a plasmid-vector encoding for the secreted fusion protein sCV1-hIgG1, comprising of highly efficient CD47-blocking moiety CV1 and Fc domain of human IgG1 with maximized immune activation.
[Molecular Therapy-Oncolytics]
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A Phase I/II Dose-Escalation Multi-Center Study to Evaluate the Safety of Infusion of Natural Killer Cells or Memory T Cells as Adoptive Therapy in Coronavirus Pneumonia and/or Lymphopenia: RELEASE Study Protocol

In the Phase I trial, 18 patients with COVID-19-related pneumonia and/or lymphopenia with no oxygen requirement or with an oxygen need of less than or equal to 2.5 liters per minute in nasal cannula were assigned to two arms, based on the biology of the donor and the patient.
[Trials]
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Specific Human Cytomegalovirus Signature Detected in NK Cell Metabolic Changes Post Vaccination

Scientists investigated metabolic and functional responses of NK cells to simian adenovirus prime and MVA boost vaccination in a cohort of healthy volunteers receiving a dual HCV-HIV-1 vaccine.
[npj Vaccines]
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Distinct Single-Component Adjuvants Steer Human DC-Mediated T-cell Polarization via Toll-Like Receptor Signaling toward a Potent Antiviral Immune Response

Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.
[Proceedings of the National Academy of Sciences of the United States of America]
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CD137 Costimulation Counteracts TGFβ Inhibition of NK-Cell Antitumor Function

Researchers demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function.
[Cancer Immunology Research]
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Senti Bio Awarded Funding from National Cancer Institute (NCI) to Support Development of Logic Gated Allogeneic CAR-NK Cell Therapy SENTI-202 to Treat Acute Myeloid Leukemia

Senti Bio announced that it has been awarded a Small Business Innovation Research contract to support further development of SENTI-202 for acute myeloid leukemia towards clinical development.
[Senti Bio]
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