breast cancer

[Nature Communications] Scientists showed that the epithelial-like and mesenchymal-like subpopulations of breast cancer stem-like cells demonstrated different levels of dormancy and tumorigenicity in lungs.

[Journal of Experimental & Clinical Cancer Research] TCGA analysis was performed to identify the clinical relevance of short stature homeobox 2 (SHOX2) in breast cancer. Molecular regulations and alterations were assessed by Western blotting, immunoprecipitation, immunohistochemistry, qRT-PCR, chromatin immunoprecipitation coupled with qPCR, and ChIP/re-ChIP.

[EMBO Journal] Scientists reported that the single nucleotide polymorphism (SNP) rs4971059, one of 65 new breast cancer risk loci identified in a recent genome-wide association study, functioned as an active enhancer of TRIM46 expression. TRIM46 promoted breast cancer cell proliferation and chemoresistance in vitro and accelerated tumor growth in vivo.

[Cell & Bioscience] Silencing small nucleolar RNA host gene 1 (SNHG1) inhibited tumorigenesis in breast cancer both in vitro and in vivo. Mechanistically, SNHG1 functioned as a competing endogenous RNA to promote TERT expression by sponging miR-18b-5p in breast cancer.

[Journal of Molecular Diagnostics] The authors provide an overview of currently available molecular assays and testing modalities that have prognostic, predictive, and therapeutic value. These include multi-gene assays for invasive breast cancer and ductal carcinoma in situ, and companion tests to detect PIK3CA mutations and NTRK fusions.

[Biochimie] To understand the role of the adipose-derived stem cell secretome in breast cancer cell proliferation, death, and phenotype alteration, adipose-derived stem cell-conditioned medium was used to cultivate MCF-7 and MDA-MB-231 cells.