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cancer stem cells

Targeting the Metabolism of Cancer Stem Cells by Energy Disruptor Molecules

[Critical Reviews in Oncology/Hematology] Investigators highlight the differences between regular cancer cells and CSC metabolism and discuss the action mechanisms of energy disruptors at the cellular and molecular levels.

Advances in Glioma-Associated Oncogene (GLI) Inhibitors for Cancer Therapy

[Investigational New Drugs] The authors review direct and indirect inhibitors of glioma-associated oncogene homolog (GLI); summarize the abundant active structurally diverse natural GLI inhibitors.

Elevated ATGL in Colon Cancer Cells and Cancer Stem Cells Promotes Metabolic and Tumorigenic Reprogramming Reinforced by Obesity

[Oncogenesis] Elevated ATGL levels in human colon cancer cells relative to non-transformed were augmented by an obesity mediator, oleic acid.

Chemotoxicity-Induced Exosomal lncFERO Regulates Ferroptosis and Stemness in Gastric Cancer Stem Cells

[Cell Death & Disease] Sphere-formation assay was used to estimate the stemness of gastric cancer stem cells. Exosomal lnc-ENDOG-1:1 (lncFERO) was isolated by ultracentrifugation.

Aptamer-Mediated Doxorubicin Delivery Reduces HCC Burden in 3D Organoids Model

[Journal of Controlled Release] Investigators developed a specific aptamer against EpCAM and tested its potential as a drug delivery agent for hepatocellular carcinoma.

pERK-Mediated IL8 Secretion Can Enhance the Migration, Invasion, and Cisplatin Resistance of CD10-Positive Oral Cancer Cells

[BMC Cancer] Researchers hypothesized that IL8 might regulate migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells through the ERK pathway.

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