miR-98-5p Inhibits Gastric Cancer Cell Stemness and Chemoresistance by Targeting Branched-Chain Aminotransferases 1

The expression of miR-98 in CD44+ gastric cancer stem cells (GCSCs) was verified by RT-PCR. The miR-98 was overexpressed in CD44+ GCSCs by Lentivirus.
[Life Sciences]
Zhan, P., Shu, X., Chen, M., Sun, L., Yu, L., Liu, J., Sun, L., Yang, Z., & Ran, Y. (2021). miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1. Life Sciences, 276, 119405. https://doi.org/10.1016/j.lfs.2021.119405 Cite
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TWIST1-Mediated Transcriptional Activation of PDGFRβ in Breast Cancer Stem Cells Promotes Tumorigenesis and Metastasis

Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast CSCs.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
Yeeravalli, R., Kaushik, K., & Das, A. (2021). TWIST1-mediated transcriptional activation of PDGFRβ in breast cancer stem cells promotes tumorigenesis and metastasis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 166141. https://doi.org/10.1016/j.bbadis.2021.166141 Cite
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Morphological and Molecular Characteristics of Spheroid Formation in HT-29 and Caco-2 Colorectal Cancer Cell Lines

Colorectal cancer spheroids were developed using hanging drop and forced floating in serum-free and non-attachment conditions and their morphological features were evaluated by scanning electron microscopy.
[Cancer Cell International]
Gheytanchi, E., Naseri, M., Karimi-Busheri, F., Atyabi, F., Mirsharif, E. S., Bozorgmehr, M., Ghods, R., & Madjd, Z. (2021). Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines. Cancer Cell International, 21(1), 204. https://doi.org/10.1186/s12935-021-01898-9 Cite
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A Novel 4D Cell Culture Mimicking Stomach Peristalsis Altered Gastric Cancer Spheroids Growth and Malignance

Scientists leveraged a lab-developed four-dimensional culture model by a magnetic responsive alginate-based hydrogel to rotating magnets that can mimic stress stimuli in gastric cancer.
[Biofabrication]
Zhao, J., Wang, R., Zhang, J., Zhao, Y., Qiao, S., Crouzier, T., Yan, H., & Tian, W. (2021). A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance. Biofabrication. https://doi.org/10.1088/1758-5090/abf6bf Cite
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Cancer Stem Cells Targets and Combined Therapies to Prevent Recurrence

The authors highlight the processes involved in CSCs development and maintenance as well as the current effective therapies based on stem cells, cell-free therapies that involve exosomes and miRNAs, and photodynamic therapy have been discussed.
[Life Sciences]
Raghav, P. K., & Mann, Z. (2021). Cancer stem cells targets and combined therapies to prevent recurrence. Life Sciences, 119465. https://doi.org/10.1016/j.lfs.2021.119465 Cite
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Stem Cell Concepts in Myelodysplastic Syndromes: Lessons and Challenges

The clinical importance of myelodysplastic syndromes (MDS) stem cells has been highlighted through the demonstration of selective persistence of MDS stem cells in patients at complete remission in response to therapy.
[Journal of Internal Medicine]
Woll, P. S., & Jacobsen, S. E. W. (n.d.). Stem cell concepts in myelodysplastic syndromes: lessons and challenges. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13283 Cite
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Understanding the Cellular Origin and Progression of Esophageal Cancer Using Esophageal Organoids

Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
[Cancer Letters]
Sachdeva, U. M., Shimonosono, M., Flashner, S., Cruz-Acuña, R., Gabre, J. T., & Nakagawa, H. (2021). Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.031 Cite
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Silencing PTEN in the Fallopian Tube Promotes Enrichment of Cancer Stem Cell-Like Function through Loss of PAX2

Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
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Tideglusib Suppresses Stem-Cell-Like Features and Progression of Osteosarcoma by Inhibiting GSK-3β/NOTCH1 Signaling

The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
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Nitidine Chloride Suppresses Epithelial-Mesenchymal Transition and Stem Cell-Like Properties in Glioblastoma by Regulating JAK2/STAT3 Signaling

Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
[Cancer Medicine]
Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
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Cancer and Stem Cells

Researchers made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse.
[Experimental Biology and Medicine]
Yin, W., Wang, J., Jiang, L., & James Kang, Y. (2021). Cancer and stem cells. Experimental Biology and Medicine, 15353702211005390. https://doi.org/10.1177/15353702211005390 Cite
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