Phenotyping Clonal Populations of Glioma Stem Cell Reveals a High Degree of Plasticity in Response to Changes of Microenvironment

Investigators used a barcode labelling approach of glioma-initiating cells to generate clonal populations over a number of passages, in combination with phenotyping using the established stem cell markers CD133, CD15, CD44, and A2B5.
[Laboratory Investigation]
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Emerging Role of G9a in Cancer Stemness and Promises as a Therapeutic Target

Scientists discuss central findings of oncogenic expression and activation of G9a in cancer stem cells from different origins, as well as the impact of the suppression of G9a histone methyltransferase activity in such contexts.
[Oncogenesis]
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The C-terminal HSP90 Inhibitor NCT-58 Kills Trastuzumab-Resistant Breast Cancer Stem-Like Cells

Researchers investigated the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-like cells.
[Cell Death Discovery]
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Nuclear Accumulation of KPNA2 Impacts Radioresistance through Positive Regulation of the PLSCR1-STAT1 Loop in Lung Adenocarcinoma

Researchers demonstrated that high expression of karyopherin α2 was positively correlated with radioresistance and CSC properties in lung adenocarcinoma cells.
[Cancer Science]
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Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

Researchers showed that inhibition of RAC1 activation attenuated pluripotency marker expression and self-renewal ability, while depletion of RAC1b dramatically enhanced stemness features and clonogenic potential.
[Cancers]
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AMBRA1 Negatively Regulates the Function of ALDH1B1, a Cancer Stem Cell Marker, by Controlling Its Ubiquitination

The expression of ALDH1B1-regulated genes, including PTEN, CTNNB1, and CSC-related β-catenin target genes, was inversely regulated by AMBRA1, suggesting a negative regulatory role of AMBRA1 in the expression of ALDH1B1-regulated genes.
[International Journal of Molecular Sciences]
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Netrin-Like Domain of sFRP4, a Wnt Antagonist Inhibits Stemness, Metastatic and Invasive Properties by Specifically Blocking MMP-2 in Cancer Stem Cells from Human Glioma Cell Line U87MG

Researchers explored the efficacy of the domains of secreted frizzled-related protein 4 (sFRP4) in inhibiting the key hallmarks of glioblastoma such as invasion, metastasis, and stemness.
[Experimental Cell Research]
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Novel Cancer Stem Cell Marker MVP Enhances Temozolomide-Resistance in Glioblastoma

Researchers found that sensitivity toTemozolomide (TMZ) was suppressed by significantly increasing the major vault protein (MVP) expression in glioblastoma multiforme cells with TMZ resistance.
[Translational Oncology]
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Tumor Stemness and Immune Infiltration Synergistically Predict Response of Radiotherapy or Immunotherapy and Relapse in Lung Adenocarcinoma

After integrating the tumor stemness index based on mRNA expression, immune score, mRNA expression, and clinical information from the TCGA database, scientists screened 380 tumor stemness and immune (TSI)-related genes and constructed a five TSI-specific-gene signature.
[Cancer Medicine]
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Dual Cancer Stem Cell Manipulation to Enhance Phototherapy against Tumor Progression and Metastasis

Investigators engineered a photodynamic nanoplatform to manipulate breast cancer stem cells against tumor progression and metastasis by not only remolding the disequilibrium state but also blocking the epithelial-mesenchymal transition process.
[Journal of Controlled Release]
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Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells

Researchers identified the cell surface binding partner of Reg4 and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.
[Molecular Cancer Research]
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