PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress

The authors isolated and characterized breast cancer stem cells from a triple-negative breast cancer cell line, MDA-MB-231. The obtained mammospheres were then treated with the specific PPARα antagonist GW6471, after which, glucose, lipid metabolism, and invasiveness were analyzed.
[Biomedicines]
Castelli, V., Catanesi, M., Alfonsetti, M., Laezza, C., Lombardi, F., Cinque, B., Cifone, M. G., Ippoliti, R., Benedetti, E., Cimini, A., & d’Angelo, M. (2021). PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress. Biomedicines, 9(2), 127. https://doi.org/10.3390/biomedicines9020127 Cite
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Radiation Response of Cervical Cancer Stem Cells Is Associated with Pretreatment Proportion of These Cells and Physical Status of HPV DNA

Scientists evaluated the association of radiation response of cervical CSCs with clinical and morphological parameters of disease and features of human papillomavirus (HPV) infection.
[International Journal of Molecular Sciences]
Zamulaeva, I., Selivanova, E., Matchuk, O., Kiseleva, V., Mkrtchyan, L., & Krikunova, L. (2021). Radiation Response of Cervical Cancer Stem Cells Is Associated with Pretreatment Proportion of These Cells and Physical Status of HPV DNA. International Journal of Molecular Sciences, 22(3), 1445. https://doi.org/10.3390/ijms22031445 Cite
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Linking EMT Programmes to Normal and Neoplastic Epithelial Stem Cells

Investigators outline the instances where aspects of an epithelial–mesenchymal transition (EMT) have been implicated in normal and neoplastic epithelial stem cells and consider the involvement of this programme during tissue regeneration and repair.
[Nature Reviews Cancer]
Lambert, A. W., & Weinberg, R. A. (2021). Linking EMT programmes to normal and neoplastic epithelial stem cells. Nature Reviews Cancer, 1–14. https://doi.org/10.1038/s41568-021-00332-6 Cite
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Targeting Cancer Stem Cells with a Pan-BCL-2 Inhibitor in Pre-Clinical and Clinical Settings in Patients with Gastroesophageal Carcinoma

Extensive pre-clinical studies in vitro and in vivo were carried out to establish the mechanism action of AT101 on targeting CSCs and antiapoptotic proteins.
[Gut]
Song, S., Chen, Q., Li, Y., Lei, G., Scott, A., Huo, L., Li, C. Y., Estrella, J. S., Correa, A., Pizzi, M. P., Ma, L., Jin, J., Liu, B., Wang, Y., Xiao, L., Hofstetter, W. L., Lee, J. H., Weston, B., Bhutani, M., … Ajani, J. A. (2021). Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut. https://doi.org/10.1136/gutjnl-2020-321175 Cite
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Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
[Cancers]
Lu, Y., Zhu, Y., Deng, S., Chen, Y., Li, W., Sun, J., & Xu, X. (2021). Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth. Cancers, 13(3), 418. https://doi.org/10.3390/cancers13030418 Cite
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Berberine Inhibits Chemotherapy-Exacerbated Ovarian Cancer Stem Cell-Like Characteristics and Metastasis through GLI1

The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.
[European Journal of Pharmacology]
Zhao, Y., Yang, X., Zhao, J., Gao, M., Zhang, M., Shi, T., Zhang, F., Zheng, X., Pan, Y., Shao, D., Li, J., He, K., & Chen, L. (2021). Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1. European Journal of Pharmacology, 895, 173887. https://doi.org/10.1016/j.ejphar.2021.173887 Cite
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Mitochondrial Oxidative Metabolism Contributes to a Cancer Stem Cell Phenotype in Cholangiocarcinoma

Investigators analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stem state in cholangiocarcinoma.
[Journal of Hepatology]
Raggi, C., Taddei, M. L., Sacco, E., Navari, N., Correnti, M., Piombanti, B., Pastore, M., Campani, C., Pranzini, E., Iorio, J., Lori, G., Lottini, T., Peano, C., Cibella, J., Lewinska, M., Andersen, J. B., Tommaso, L. di, Vigano, L., Maira, G. D., … Marra, F. (2021). Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma. Journal of Hepatology, 0(0). https://doi.org/10.1016/j.jhep.2020.12.031 Cite
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Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

The authors investigated the expression of components of the renin-angiotensin system by CSC subpopulations in metastatic head and neck cutaneous squamous cell carcinoma.
[Cells]
Siljee, S., Buchanan, O., Brasch, H. D., Bockett, N., Patel, J., Paterson, E., Purdie, G. L., Davis, P. F., Itinteang, T., & Tan, S. T. (2021). Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System. Cells, 10(2), 243. https://doi.org/10.3390/cells10020243 Cite
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Requirement of Splicing Factor hnRNP A2B1 for Tumorigenesis of Melanoma Stem Cells

The authors showed that out of 19 evaluated hnRNPs, hnRNP A2B1 was significantly upregulated in melanoma stem cells compared with non-stem cells, suggesting an important role of hnRNP A2B1 in cancer stem cells.
[Stem Cell Research & Therapy]
Chu, M., Wan, H., & Zhang, X. (2021). Requirement of splicing factor hnRNP A2B1 for tumorigenesis of melanoma stem cells. Stem Cell Research & Therapy, 12(1), 90. https://doi.org/10.1186/s13287-020-02124-5 Cite
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Phage Display Screening Identifies a Prostate Specific Antigen (PSA)–/Lo Prostate Cancer Cell Specific Peptide to Retard Castration Resistance of Prostate Cancer

Prostate-specific antigen (PSA)+ and PSA−/lo cells were successfully separated from LNCaP xenograft tumors after prostate- PSAP-GFP vector infection and FACS.
[Translational Oncology]
Sui, Y., Zhu, R., Hu, W., Zhang, W., Zhu, H., Gong, M., Gao, L., Cao, T., Tang, T., Yu, B., & Yang, T. (2021). Phage display screening identifies a prostate specific antigen (PSA)–/lo prostate cancer cell specific peptide to retard castration resistance of prostate cancer. Translational Oncology, 14(3), 101020. https://doi.org/10.1016/j.tranon.2021.101020 Cite
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RNA Binding Protein PUM1 Promotes Colon Cancer Cell Proliferation and Migration

Investigators found that pumilio-1 (PUM1) mRNA expression was high in primary and metastatic colon cancer cell lines when compared to the normal colon cell line.
[International Journal of Biological Macromolecules]
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