cancer stem cells

[Seminars in Cancer Biology] The authors summarize the recent advances in cancer pathological roles and mechanisms of RNA-binding proteins (RBPs) in regulating mRNA stability and translation with an emphasis on the emerging category of RNA modification-associated RBPs.

[Scientific Reports] Using MRI, scientists determined the correlation between glutamine uptake and the distribution of glutamine transporters, namely ASCT2 and SLC38A2, glutaminase, and CSC markers, such as CD44 and CD166, in a mouse xenograft model of HT29 human colorectal cancer cells.

[Journal of Clinical Investigation] Through comparative chromatin state and gene expression analyses in ovarian CSCs vs. non-CSCs, researchers identified FOXK2 as a highly expressed stemness-specific transcription factor in ovarian cancer.

[Aging] Scientists identified that the treatment of levobupivacaine suppressed proliferation of osteosarcoma cells in vitro.

[Cell Death & Differentiation] The authors illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum response via mitochondrial reactive oxygen species level.

[Life Sciences] Scientists discuss a brief yet functional idea of emerging concepts in CSC biology to develop efficient therapeutics acting on cancer recurrence and metastasis.