The expression of miR-98 in CD44+ gastric cancer stem cells (GCSCs) was verified by RT-PCR. The miR-98 was overexpressed in CD44+ GCSCs by Lentivirus.
6445212 HCQ5I5UX items 1 apa default asc 1
Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast CSCs.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
6445212 F5T4UBP3 items 1 apa default asc 1
Colorectal cancer spheroids were developed using hanging drop and forced floating in serum-free and non-attachment conditions and their morphological features were evaluated by scanning electron microscopy.
[Cancer Cell International]
6445212 SE4DL886 items 1 apa default asc 1
Gheytanchi, E., Naseri, M., Karimi-Busheri, F., Atyabi, F., Mirsharif, E. S., Bozorgmehr, M., Ghods, R., & Madjd, Z. (2021). Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines. Cancer Cell International, 21(1), 204. https://doi.org/10.1186/s12935-021-01898-9 Cite
Scientists leveraged a lab-developed four-dimensional culture model by a magnetic responsive alginate-based hydrogel to rotating magnets that can mimic stress stimuli in gastric cancer.
6445212 QT9P4GYC items 1 apa default asc 1
The authors highlight the processes involved in CSCs development and maintenance as well as the current effective therapies based on stem cells, cell-free therapies that involve exosomes and miRNAs, and photodynamic therapy have been discussed.
The clinical importance of myelodysplastic syndromes (MDS) stem cells has been highlighted through the demonstration of selective persistence of MDS stem cells in patients at complete remission in response to therapy.
[Journal of Internal Medicine]
6445212 G9EY7CGQ items 1 apa default asc 1
Woll, P. S., & Jacobsen, S. E. W. (n.d.). Stem cell concepts in myelodysplastic syndromes: lessons and challenges. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13283 Cite
Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
6445218 BL6TEXCY items 1 apa default asc 1
Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
6445212 6J2GTZGR items 1 apa default asc 1
Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
6445212 PEF7TF6N items 1 apa default asc 1
Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
6445212 TE4DXLB9 items 1 apa default asc 1
Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
Researchers made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse.
[Experimental Biology and Medicine]